Transcription factor activity profiling uncovers prognostic subtypes and a novel oncogenic role for PRDM4 in NSMP endometrial carcinoma [0.03%]
转录因子活性谱系分析揭示了NSMP子宫内膜癌的预后亚型及PRDM4的新致癌作用
Sisi Liu,Min Sun,Xiuying Wang et al.
Sisi Liu et al.
Background: Among the four molecular subtypes of endometrial carcinoma (EC), the no specific molecular profile (NSMP) group is the largest, comprising roughly 40-50% of cases. Patients within this subtype follow markedly ...
Nonlinear association between baseline albumin-to-alkaline phosphatase ratio and overall survival in advanced NSCLC treated with anlotinib: a two-center retrospective cohort study [0.03%]
基线血清白蛋白与碱性磷酸酶比值与晚期非小细胞肺癌患者口服安罗替尼生存预后的非线性关联：一项两中心回顾性队列研究
Ning Zhang,Zhenyang Lin,Jinzhan Chen et al.
Ning Zhang et al.
Background: The albumin-to-alkaline phosphatase ratio (AAPR) has been reported as a prognostic biomarker in several malignancies, but its clinical relevance in advanced non-small cell lung cancer (NSCLC) patients treated ...
NoRCa: a register-based data source for cancer research in northern Sweden [0.03%]
NoRCa：瑞典北部癌症研究的基于注册的数据源
Cecilia Hultstrand,David Olsson,Senada Hajdarevic et al.
Cecilia Hultstrand et al.
Background: Rural populations often have poorer health outcomes than urban residents due to limited healthcare access, long travel distances, and diagnostic delays. Northern Sweden, covering 55% of the country but only 10...
Impact of immunotherapy as a monotherapy or in combination with conventional therapies on regulatory T-cell (Treg) modulation in prostate cancer: a systematic review [0.03%]
免疫治疗作为单药或联合常规疗法对前列腺癌调节性T细胞(Treg)的调控影响：系统综述
Olayemi Oluseun Akinnola,Ayomide Iyanuoluwa Olaniyan,Barnabas Adeoluwa Adeboye et al.
Olayemi Oluseun Akinnola et al.
Background: Prostate cancer is known to have a cold tumor microenvironment (TME) that promotes immune evasion through different cellular pathways. Aggressive disease progression is often linked to Regulatory T cells (Treg...
Multi-omics profiling highlights RPLP0 as a potential biomarker for prognosis and response to immunotherapy in clear cell renal cell carcinoma [0.03%]
多组学分析揭示RPLP0可能是透明细胞肾细胞癌预后和免疫治疗反应的潜在生物标志物
Bin Wang,Hongquan Liu,Yicheng Guo et al.
Bin Wang et al.
Background: Clear cell renal cell carcinoma (ccRCC) is characterized by intratumoral heterogeneity and a complex immune microenvironment, which contribute to disease progression and therapeutic resistance. Although riboso...
A new prognostic perspective on preoperative coagulation parameters for lung adenocarcinoma patients: development and validation of the DFP score [0.03%]
肺癌低剂量螺旋CT筛查标测化智能决策系统的建立与初步评估
Lubei Rao,Hongyan Lin,Guiji Zhang et al.
Lubei Rao et al.
Background: Emerging evidence suggests a pivotal role of coagulation-related factors in tumor progression and survival outcomes. However, their integration into risk stratification models remains limited. This study aimed...
Neoadjuvant chemoimmunotherapy versus chemotherapy for locally advanced esophageal squamous cell carcinoma: a retrospective cohort study [0.03%]
新辅助化疗免疫治疗与单纯化疗局部晚期食管鳞癌患者的疗效比较：一项回顾性队列研究
Yixing Li,Haozhe An,Fan Yang et al.
Yixing Li et al.
Background: Neoadjuvant chemoimmunotherapy (NCIT) has shown promising activity in locally advanced esophageal squamous cell carcinoma (ESCC), but comparative evidence against neoadjuvant chemotherapy (NCT) alone remains l...
A multicenter prediction model for false-positive clinical nodal disease in < 4-cm NSCLC: clinical implications for upfront surgery versus neoadjuvant therapy [0.03%]
Tetsuya Isaka,Yui Kaburaki,Ikki Takada et al.
Tetsuya Isaka et al.
Background: Perioperative immunochemotherapy is recommended for resectable non-small cell lung cancer (NSCLC) with ≥ 4-cm tumors or clinical nodal involvement (cN(+)). Therefore, accurate preoperative nodal assessment is...
Metabolome-microbiome convergence under circadian disruption accelerates mammary tumorigenesis: multi-omics integration insights [0.03%]
代谢组-微生物组在生物钟紊乱下汇聚加速乳腺肿瘤发生：多组学整合见解
Mrinmoy Sarkar,Olajumoke Ogunlusi,Trenton Stewart et al.
Mrinmoy Sarkar et al.
Circadian rhythm disruption (CRD), common in shift work and jet lag, promotes mammary tumorigenesis through coordinated reprogramming of tumor metabolism and the local microbiome. CRD increased immunosuppressive metabolites - kynurenic acid...
Serglycin-ROS axis mediates synergistic lethality of PI3Kγ inhibition and Azacitidine in TP53-mutated AML [0.03%]
Serglycin-ROS轴介导PI3Kγ抑制和阿扎胞苷在TP53突变型AML中的协同致死作用
Guiqin Huang,Xiaoya Cai,Yeming Zhou et al.
Guiqin Huang et al.
Purpose: To investigate novel combination strategies for TP53-mutated acute myeloid leukemia (AML), focusing on the potential synergy between PI3Kγ inhibition and Azacitidine, and to elucidate the underlying molecular me...