Comparative effectiveness of radical surgery versus concurrent chemoradiotherapy in stages IB3, IIA2, or locally resectable IIICr cervical cancer: a prospective, multicenter, propensity score-matched cohort study [0.03%]
广泛期IB3、IIA2或可切除的IIICr宫颈癌患者根治性手术与同步放化疗比较效果的前瞻性多中心倾向性评分匹配队列研究
Qinqin Liu,Wenwen Liu,Yan Huang et al.
Qinqin Liu et al.
Background: While concurrent chemoradiotherapy (CCRT) is the standard first-line treatment, radical surgery (RS) is frequently preferred in China, despite unclear comparative efficacy. The role of minimally invasive surge...
Analysis of factors influencing SARS-CoV-2 infection and outcomes in patients with chronic lymphocytic leukemia during the burst of COVID-19 epidemic [0.03%]
新冠病毒疫情高发期间慢性淋巴细胞白血病患者感染及影响因素分析
J Wang,S Wang,F Xu et al.
J Wang et al.
Background: CLL patients have immune deficiencies and are at high risk of SARS-CoV-2 infection. Limited research exists on risk factors and survival outcomes of SARS-CoV-2 infection in Asian CLL patients during the COVID-...
Human single domain antibody-based CAR-T cells targeting BAFF-R demonstrate promising preclinical activity in B-cell malignancies [0.03%]
基于人类单域抗体的CAR-T细胞靶向BAFF-R在B细胞恶性肿瘤中的临床前活性显著
Cuiling Zhang,Qian Luo,Sungui Wu et al.
Cuiling Zhang et al.
Background: Single-chain antibody-based CAR-T cells targeting BAFF-R have demonstrated antitumor effects against human B-cell malignancies and can overcome CD19 antigen loss. However, CARs built on antigen-specific single...
Network-based integrative transcriptomic analysis reveals immune-regulatory and oncogenic signatures of EOMES and SPRYD3 in head and neck squamous cell carcinoma [0.03%]
基于网络的整合转录组分析揭示EOMES和SPRYD3在头颈部鳞状细胞癌中免疫调节和致癌特征
Liming He,Yiyu Zeng,Yijun Gao et al.
Liming He et al.
Background: Head and neck squamous cell carcinoma (HNSCC) exhibits marked heterogeneity driven by both tumor-intrinsic programs and immune context. However, the relationship between epithelial proliferation and immune act...
A Abu Hejleh,J Lemties,I Kreutzer et al.
A Abu Hejleh et al.
Background: Esophagectomy (OE) remains a complex procedure with a considerable risk of severe postoperative complications. There is conflicting evidence if major postoperative complications impair long-term oncological su...
ITGAX is associated with poor prognosis and an immune-inflammatory microenvironment in clear cell renal cell carcinoma [0.03%]
ITGAX与透明细胞肾细胞癌预后不良及免疫炎症微环境的相关性
Xuehua Chen,Zongrong Lin,Ranran Zhang et al.
Xuehua Chen et al.
Background: Integrin alpha X (ITGAX, CD11c) functions as a leukocyte adhesion molecule vital for immune cell activation, antigen presentation, and inflammatory responses. However, the expression profile, clinical relevanc...
The impact of abiraterone and enzalutamide on hypokalemia incidence in patients with prostate cancer: a systematic review and meta-analysis [0.03%]
阿比特龙和恩扎卢胺对前列腺癌患者低钾血症发病率影响的系统评价和meta分析
Yibo Lou,Dejun Fan,Tiejiang Chen et al.
Yibo Lou et al.
Objective: To systematically evaluate the incidence of hypokalemia associated with novel androgen receptor axis-targeted therapies (ARATs)-specifically abiraterone, enzalutamide, and their combination-in patients with adv...
Meta-Analysis
BMC cancer. 2026 Jul 2;26(1):804. DOI:10.1186/s12885-026-16108-w 2026
Delaying surgery beyond six weeks after systemic therapy reduces postoperative morbidity without evidence of impaired oncologic outcomes in colorectal liver metastases [0.03%]
系统性治疗后超过6周再手术不影响结直肠癌肝转移患者预后但可减少术后并发症
Esther Giehl-Brown,Rajan Nikbakhsh,Ana Mansourkiaei et al.
Esther Giehl-Brown et al.
Background: The optimal timing of resection for colorectal liver metastases (CRLM) after systemic therapy remains unclear. This study evaluated the impact of time-to-surgery (TTS) on postoperative morbidity and oncologic ...
Perioperative NLR/PLR dynamic phenotypes and prediction of postoperative recurrence in locally advanced gastric cancer: a retrospective cohort study [0.03%]
基于回顾性队列研究的局部进展期胃癌术后复发与术前、术中及术后不同时间点NLR/PLR表型分布的关系
Yinxiao Wu,Jie Zhou,Su Li et al.
Yinxiao Wu et al.
Background: Systemic inflammation plays a critical role in tumor progression and postoperative recurrence in gastric cancer. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are readily acce...
NT5E promotes colorectal cancer progression and correlates with PD-L1 expression: evidence from multi-omics analysis, clinical samples, and cellular functional assays [0.03%]
NT5E促进结直肠癌进展并伴随PD-L1表达：来自多组学分析、临床样本和细胞功能试验的证据
Weixing Wu,Cheng Cheng,Tao Yang et al.
Weixing Wu et al.
Background: Extracellular 5'-nucleotidase (NT5E/CD73) plays a pivotal role in the tumor immune microenvironment by catalysing the production of adenosine. This study aims to evaluate the expression and function of NT5E in...