Using skin biopsies to measure target occupancy of anti-fibrotic molecules: assay development and application for zampilimab in a primate model of chronic kidney disease and in healthy human volunteers [0.03%]
用于测量抗纤维化分子目标占用率的皮肤活检测定：斑马利单抗在慢性肾脏病灵长类模型和健康人类志愿者中的方法建立与应用
Linghong Huang,Rowann Bowcutt,Alison Bigley et al.
Linghong Huang et al.
Background: Assessing target engagement (TE) and target occupancy (TO) of novel antifibrotic molecules is challenging, as the target organs are inaccessible. In clinical trials, this often requires biopsies of internal or...
Insights on the practical application of the current treatment consensus in rhabdomyolysis management: a case report [0.03%]
当前横纹肌溶解症治疗共识的实际应用体会——1例报告
Theresa Gier,Sebastian Koball,Matteo Marcello et al.
Theresa Gier et al.
Background: Hemoadsorption has emerged as a promising adjunctive therapy in the management of various inflammatory and toxin-mediated conditions. Its role in context of rhabdomyolysis has generated increasing scientific a...
Total bilirubin as a mortality predictor in non-elderly hemodialysis patients: a multicenter retrospective cohort study [0.03%]
总胆红素作为非老年血液透析患者的死亡率预测因子：一项多中心回顾性队列研究
Yuyang Chen,Haowen Zhang,Hongyan Liu et al.
Yuyang Chen et al.
Background: The association between serum total bilirubin (TBIL) levels and mortality in maintenance hemodialysis (MHD) patients, especially when stratified by age, has not been clearly established. ...
Multicenter Study
BMC nephrology. 2025 Nov 20;26(1):655. DOI:10.1186/s12882-025-04621-2 2025
Analysis of prognostic risk factors in critically ill elderly patients with sepsis-associated acute kidney injury [0.03%]
重症脓毒症相关急性肾损伤患者的预后危险因素分析
Jiangwei Zeng,Yu Zhang,Mengxin Zhang et al.
Jiangwei Zeng et al.
Background: To investigate the risk factors influencing the prognosis of critically ill elderly patients with sepsis-associated acute kidney injury (SA-AKI). ...
The "Picasso faces" of diabetic kidney disease - how the art of phenotyping and molecular biomarkers is transforming clinical nephrology: an observational study in patients with type 2 diabetes [0.03%]
糖尿病肾病的“毕加索面孔”——表型和分子生物标志物的艺术如何变革了临床肾脏病学：2 型糖尿病患者的观察性研究
Małgorzata Rodzoń-Norwicz,Natalia Potocka,Marzena Skrzypa et al.
Małgorzata Rodzoń-Norwicz et al.
Background and hypothesis: Diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM) presents heterogeneously, complicating risk assessment. This study evaluated microRNAs and other biomarkers for DKD...
Observational Study
BMC nephrology. 2025 Nov 19;26(1):652. DOI:10.1186/s12882-025-04592-4 2025
Serum angiotensinogen as a biomarker for renal outcomes in patients with acute myocardial infarction: prognostic significance and clinical implications [0.03%]
急性心肌梗死患者肾预后标志物血管紧张素原临床意义及其预后价值
Xiaoqin Zhang,Haoyong Zhang,Xi Liu et al.
Xiaoqin Zhang et al.
Background/Aims: Acute kidney injury (AKI), also referred to as type 1 cardiorenal syndrome (CRS), is a frequent complication of acute myocardial infarction (AMI), with reported incidence rates in the literature ranging f...
Inflammatory markers predict MIA syndrome progression and cardiovascular disease outcomes in maintenance dialysis patients [0.03%]
炎症标志物可预测维持性血液透析患者MIA综合征的进展和心血管预后
Sha Chen,Ping Yang,Hongyun Lv et al.
Sha Chen et al.
Objective: To investigate associations between inflammatory markers and malnutrition-inflammation-atherosclerosis (MIA) syndrome in dialysis patients and evaluate their predictive value for cardiovascular events. ...
Remote and home-based management for maintenance peritoneal dialysis patients: a retrospective cohort study using internet hospital and Four-Party Linkage models [0.03%]
基于互联网医院和四方联动模式的腹膜透析远程管理和居家管理效果回顾性研究
Biling Fu,Cuiyun Liu,Qingcheng Zeng et al.
Biling Fu et al.
Objective: To evaluate the effectiveness of the remote management based on the Internet Hospital and Family-Sicked Bed strategy under the Four-Party Linkage model among patients with maintenance peritoneal dialysis (PD). ...
Observational Study
BMC nephrology. 2025 Nov 19;26(1):650. DOI:10.1186/s12882-025-04536-y 2025
Age-stratified mortality and associated risk factors in adults aged 65 years or older undergoing continuous kidney replacement therapy: a consecutive retrospective study [0.03%]
连续性肾脏替代治疗老年患者年龄分层的死亡率及其相关危险因素：一项连续性回顾性研究
Seong-Wook Lee,Yu Jin Seo,Jeong-Hoon Lim et al.
Seong-Wook Lee et al.
Background: As life expectancy increases and more adults aged ≥ 65 years undergo continuous kidney replacement therapy (CKRT), grouping patients into narrower age groups-rather than treating those aged ≥ 65 years as a s...
Access recirculation in continuous kidney replacement therapy with regional citrate anticoagulation: a case report and diagnostic insights [0.03%]
枸橼酸局部抗凝连续性肾脏替代疗法中的再循环现象一例及诊断思考
Shu Huei Neo,Zhong Hong Liew,Manish Kaushik;S.I.N:G.A.P.O.R.E Initiative (Science in Nephrology: Growth and Progress of Research and Education)
Shu Huei Neo
Background: Vascular access recirculation (AR) is an underrecognized but clinically significant cause of inadequate solute clearance during continuous kidney replacement therapy (CKRT). Access recirculation can be easily ...