Nitidine chloride inhibits colorectal cancer by targeting BUB1: mechanistic insights from molecular dynamics simulation, spatial transcriptomics, and single-cell RNA sequencing [0.03%]
氯化尼挺丁通过靶向BUB1抑制结直肠癌：来自分子动力学模拟，空间转录组和单细胞RNA测序的机制见解
Ke-Jun Wu,Jin-Cheng Li,Li-Min Liu et al.
Ke-Jun Wu et al.
Background: Colorectal cancer (CRC) is a prevalent malignancy with the efficacy of current treatments limited. Nitidine chloride (NC), a natural alkaloid, exhibits antitumor potential, but its mechanism in CRC remains unc...
Gastrointestinal symptoms in adults with Fabry disease and their associations with physical and mental health [0.03%]
法布雷病成人患者胃肠症状及其与身心健康的关联性研究
Mina Susanne Weedon-Fekjær,Hege Kampen Pihlstrøm,Harald Weedon-Fekjær et al.
Mina Susanne Weedon-Fekjær et al.
Background: Fabry disease is a rare X-linked lysosomal storage disorder that affects multiple organ systems, including the gastrointestinal tract. The aims were to characterize the prevalence, characteristics, and severit...
A CT-based decision tree model for differentiating sub-3 cm gastric ectopic pancreas from gastrointestinal stromal tumors [0.03%]
基于CT的决策树模型用于鉴别小于3cm的胃异位胰腺和胃肠间质瘤
Jiaqi Duan,Yunzhi Zhao,Qihao Shi et al.
Jiaqi Duan et al.
Objective: To develop a CT-based decision tree model integrating clinical and imaging features for the preoperative differentiation of gastric ectopic pancreas (GEPs) and gastrointestinal stromal tumors (GISTs) with a max...
The albumin-to-creatinine ratio predicts and explores potential mediation of mortality in metabolic dysfunction-associated steatotic liver disease in U.S. adults: evidence from NHANES 1999-2018 [0.03%]
白蛋白/肌酐比值预测并探索代谢功能异常相关脂肪性肝病在美国成年人中的潜在中介死亡率：1999-2018年NHANES证据
Huanjie Zhou,Hao Huang,Huiliu Zhao et al.
Huanjie Zhou et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) frequently coexists with chronic kidney disease, which may exacerbate adverse outcomes. The albumin-to-creatinine ratio (ACR), an established ma...
Efficacy and safety analysis of D-TACE combined with lenvatinib in the treatment of hepatocellular carcinoma refractory to C-TACE [0.03%]
药物洗脱微球载朵妥昔单抗玻璃珠肝动脉化疗联合仑伐替尼治疗常规肝动脉化疗栓塞失败的肝细胞癌患者的有效性和安全性分析
Haohao Lu,Bin Liang,Chuansheng Zheng et al.
Haohao Lu et al.
Background: Transarterial chemoembolization (TACE) is a standard treatment for unresectable hepatocellular carcinoma (HCC). However, a significant proportion of patients develop conventional TACE (cTACE) refractoriness, w...
Global, regional, and national burden of early-onset and late-onset colorectal cancer attributable to high body-mass index from 1990 to 2021: a trend analysis and forecasts up to 2040 based on the global burden of disease study 2021 [0.03%]
基于2021年全球疾病负担研究的1990年至2021年的身体质量指数升高所致结直肠癌过早发病与晚年发病的全球、区域和国家疾病负担及未来趋势预测至2040年分析
Bin Yue,Zhongqiao Lu,Deshan Zong et al.
Bin Yue et al.
Background: The global burden of colorectal cancer (CRC) has been steadily rising. However, a key knowledge gap persists regarding the HBMI-attributable burden in early-onset (EOCRC) versus late-onset (LOCRC) cases. The t...
Association between the red cell distribution Width - coefficient of variation with colon cancer and all-cause mortality: insights from the 1999-2018 NHANES [0.03%]
1999-2018年NHANES的红细胞分布宽度变异系数与结直肠癌和全因死亡率的关系：来自1999-2018年NHANES的见解
Xue Li,Yunxian He,Peiwen Yuan et al.
Xue Li et al.
Background: This study examined the link between red cell distribution width - coefficient of variation (RDW-CV) levels, colon cancer, and all-cause mortality in the community population. ...
Effect of endoscopic treatment for lesions in radiotherapy field after radiotherapy for rectal cancer [0.03%]
放疗后直肠癌照射区病变内镜下治疗的疗效分析
Bowen Zha,Lizhou Dou,Yong Liu et al.
Bowen Zha et al.
Background: Lesions manifesting after radiotherapy are difficult to treat. Significant inflammations often manifest at the rectal wall after radiotherapy, the rectal wall often experiences significant inflammation, and th...
A qualitative investigation into the psychological experiences of patients undergoing thoracotomy for the removal of intraesophageal fishbone [0.03%]
胸腔镜取异物术患者的心理体验质性研究
Xiaoying Hou,Junhui Wang,Wenbin Zou
Xiaoying Hou
Background: Esophageal foreign bodies, especially fish bones, are common emergencies that may require surgery like thoracotomy. Psychological impacts such as pain and anxiety are often overlooked. This study explores pati...
Association between Helicobacter pylori infection and hospital-acquired upper gastrointestinal bleeding: a prospective case-control study [0.03%]
Hp感染与医院获得性上消化道出血的关联：一项前瞻性队列研究
Setthachai Piwchan,Ekawee Sripariwuth,Suppana Chuensakul
Setthachai Piwchan
Background: In-hospital bleeding increases hospital stays and mortality. Prolonged mechanical ventilation and coagulopathy are known risk factors. Helicobacter pylori (H. pylori) is associated with upper gastrointestinal ...