Beyond Gilbert syndrome: exploring the heterozygous UGT1A1 c.41_40dup variant as a potential modifier of bile composition associated with a cholangiopathic phenotype in adults with unexplained chronic cholestasis [0.03%]
超出吉尔伯特综合征的范畴：探讨异源UGT1A1 c.41_40dup变异作为成人不明原因慢性胆汁淤积性胆管病胆汁组成相关修饰因子的潜在作用
Alessandro Federico,Mario Romeo,Fiammetta Di Nardo et al.
Alessandro Federico et al.
Background: Unexplained chronic cholestasis (UCC) in adults is traditionally interpreted as a hepatocellular or canalicular disorder; however, a subset of patients may instead exhibit a cholangiopathy-driven phenotype. Ur...
Meta-analysis: safety and efficacy of ustekinumab in pediatric inflammatory bowel disease patients with anti-TNF failure [0.03%]
乌司奴单抗治疗抗TNF失败的儿童炎症性肠病患者的安全性和有效性 meta分析
Zhaoyang Heng,Li Zhan,Yuhan Zhang et al.
Zhaoyang Heng et al.
Background & aims: Evidence for ustekinumab (UST) in pediatric inflammatory bowel disease (IBD) is limited, particularly in patients who do not respond to anti-tumor necrosis factor (anti-TNF) therapy. We conducted a meta...
Cholangioscopy-guided laser lithotripsy for difficult pancreatobiliary duct stones: a single-center experience with high single-session duct clearance [0.03%]
胆胰管困难结石内镜激光碎石术：单中心高一次性清除率报告
Şakir Karpuz,Mümin Coşkun
Şakir Karpuz
Background and study aims: The management of difficult pancreatobiliary duct stones remains challenging, particularly in patients with large or impacted stones, unfavorable anatomy, or prior failed endoscopic intervention...
Comparative study on the detection efficacy of KU-F50 centrifugal method and routine detection methods for gastrointestinal parasites [0.03%]
KU-F50离心浓缩法与常规方法检测消化道寄生虫病效果比较研究
Rongjiang Liu,Kaili Qin,Shaoheng Huang et al.
Rongjiang Liu et al.
Objective: To compare the detection performance of three automated fecal methods for common gastrointestinal parasites and assess the analytical validity of the KU-F50 centrifugal sedimentation method. ...
Accelerated biological aging and the risk of incident liver cancer: a prospective cohort study of the UK biobank [0.03%]
加速生物衰老与肝癌发病风险的关系：英国生物银行前瞻性队列研究
Xiaojuan Liu,Shuangshuang Yang,Conghui Zhang et al.
Xiaojuan Liu et al.
Background: While conventional risk factors for liver cancer are well-established, the contribution of biological aging to hepatocarcinogenesis remains poorly understood, representing an important gap in its etiological f...
The role of machine perfusion in preventing recurrence after liver transplant for hepatocellular carcinoma: a systematic review and meta-analysis [0.03%]
机器灌注在预防肝癌肝移植术后复发中的作用：系统评价和meta分析
Ibrahim U Garzali,Ez El Din Abou Zeid,Ali Aloun et al.
Ibrahim U Garzali et al.
Background: Hepatocellular carcinoma (HCC) is a leading indication for liver transplantation (LT), but post-transplant recurrence remains a major cause of treatment failure. Ischemia-reperfusion injury (IRI) has been impl...
Risk factors and development of a predictive model for chronic kidney disease in patients with metabolic dysfunction-associated steatotic liver disease [0.03%]
代谢功能紊乱相关肝脂肪变性疾病患者的慢性肾脏病的风险因素及预测模型的建立与发展
Jiaojiao Zhu,Yiwen Liu,Siqian Lu et al.
Jiaojiao Zhu et al.
Aim: To identify risk factors for chronic kidney disease (CKD) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and to develop a risk prediction model for CKD comorbidity within this popul...
Timing of endoscopy and short-term outcomes in cirrhotic patients with acute variceal bleeding: a single-center retrospective study [0.03%]
肝硬化急性静脉曲张出血内镜治疗时机及短期预后：单中心回顾分析
Weixu Chen,Zhiyuan Lu,Hai Wu et al.
Weixu Chen et al.
Background: The optimal timing of endoscopy for acute variceal bleeding (AVB) remains uncertain in real-world clinical practice. This study aimed to evaluate the association between endoscopy timing and short-term outcome...
Ectopic gastric squamous metaplasia with concomitant well-differentiated adenocarcinoma: a case report [0.03%]
异位胃角化上皮化生伴并发的分化好的腺癌病例报告
Kenichi Takahashi,Satoshi Osawa,Rei Ishikawa et al.
Kenichi Takahashi et al.
Background: Gastric squamous metaplasia is a rare condition whose clinical significance and malignant potential remain unclear. Most reported cases are located in the cardia and are continuous with the esophageal squamous...
Real-world study of posaconazole tablets for the prophylaxis of invasive fungal disease in patients with end-stage liver disease [0.03%]
晚期肝病患者侵袭性真菌病预防用泊沙康唑片的现实世界研究
Yunru Chen,Lei Shi,Xi Zhang et al.
Yunru Chen et al.
Background: Data on the pharmacokinetics and tolerability of posaconazole delayed-release tablets in patients with end-stage liver disease (ESLD)(including liver failure and decompensated cirrhosis) remain limited. This s...