RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db mice [0.03%]
RU486不会加重LPS攻击的小鼠或db/db小鼠的细胞因子释放
Baichun Yang,Ryan P Trump,Ying Shen et al.
Baichun Yang et al.
Background: Glucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory response, and concerns over this exacerba...
Andreas W Henkel,Wolfgang Sperling,Andrea Rotter et al.
Andreas W Henkel et al.
Background: Different classes of antidepressant drugs are used as a treatment for depression by activating the catecholinergic system. In addition, depression has been associated with decrease of growth factors, which cau...
Jose C Nacher,Jean-Marc Schwartz
Jose C Nacher
Background: Network science is already making an impact on the study of complex systems and offers a promising variety of tools to understand their formation and evolution in many disparate fields from technological netwo...
Role of sulphated polysaccharides from Sargassum Wightii in Cyclosporine A-induced oxidative liver injury in rats [0.03%]
石上磺化多糖对环孢素A致大鼠氧化性肝损伤的保护作用研究
Anthony Josephine,Kalaiselvam Nithya,Ganapathy Amudha et al.
Anthony Josephine et al.
Background: Seaweeds or marine algae have long been made up a key part of the Asian diet, and as an antioxidant, sulphated polysaccharides have piqued the interest of many researchers as one of the ocean's greatest treasu...
Inhibition of 11betaHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice [0.03%]
用S-苯乙基氨基噻唑酮BVT116429抑制11βHSD1可增加糖尿病KKAy小鼠的脂联素浓度和改善糖稳态
Maj Sundbom,Christina Kaiser,Eva Björkstrand et al.
Maj Sundbom et al.
Background: A substantial body of evidence indicates that reduced plasma adiponectin levels may be key in the development of insulin resistance, type 2 diabetes and the metabolic syndrome. Glucocorticoids decrease the lev...
Comparative study of the antimutagenic properties of vitamins C and E against mutation induced by norfloxacin [0.03%]
维生素C和E对抗诺氟沙星诱发突变的抗突变性比较研究
Myriam Arriaga Alba,Roberto Rivera Sánchez,Nancy Jannet Ruíz Pérez et al.
Myriam Arriaga Alba et al.
Background: Norfloxacin like other fluoroquinolones, is known to mbe mutagenic for Salmonella typhimurium TA102 strain. This mutagenic effect is due to free oxygen radicals (ROS), because it is inhibited by antioxidants s...
Comparative Study
BMC pharmacology. 2008 Feb 11:8:2. DOI:10.1186/1471-2210-8-2 2008
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia [0.03%]
琥珀酸二胆碱盐，一种神经元胰岛素增敏剂，可改善正常衰老、慢性脑低灌注和β-淀粉样蛋白片段（25-35）所致遗忘的啮齿动物模型的认知缺损
Zinaida I Storozheva,Andrey T Proshin,Vladimir V Sherstnev et al.
Zinaida I Storozheva et al.
Background: Accumulated evidence suggests that insulin resistance and impairments in cerebral insulin receptor signaling may contribute to age-related cognitive deficits and Alzheimer's disease. The enhancement of insulin...
The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment [0.03%]
β2-肾上腺素受体的存在使α2A-肾上腺素受体在慢性肾上腺素处理后去敏化
Tasneem Bawa-Khalfe,Ghazi F Altememi,Chitra D Mandyam et al.
Tasneem Bawa-Khalfe et al.
Background: In addition to the regulation of blood pressure, alpha2- and beta-adrenoceptor (AR) subtypes play an important role in the modulation of noradrenergic neurotransmission in the human CNS and PNS. Several studie...
Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts [0.03%]
与小细胞肺癌异种移植物相比，血红素e6-聚乙烯吡咯酮介导的光动力治疗有效抑制人类非小细胞肺癌异种移植物的增长
William W L Chin,Paul W S Heng,Malini Olivo
William W L Chin
Background: Photodynamic therapy (PDT) is an effective local cancer treatment that involves light activation of a photosensitizer, resulting in oxygen-dependent, free radical-mediated cell death. Little is known about the...
Abstracts of the 13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT), Vienna, Austria, 22-24 November 2007 [0.03%]
奥地利药理学会第13届科学研讨会会议摘要（APHR）与奥地利毒理学协会和匈牙利实验与临床药理学协会联合会议，奥地利维也纳，2007年11月22-24日
Georg M Singewald,Karl Ebner,Nigel Whittle et al.
Georg M Singewald et al.