Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration [0.03%]
反复应用去甲替林对成人和13日龄大鼠直肠温度的影响及其与α-2肾上腺素能受体的关系
Jean D Deupree,William J Burke,David B Bylund
Jean D Deupree
Background: The effects of acute and repeated treatment with desipramine on the functional response of alpha2-adrenoceptors were tested in adult and 13-day old rats. The functional response measured was hypothermia that w...
Comparative Study
BMC pharmacology. 2008 Oct 2:8:17. DOI:10.1186/1471-2210-8-17 2008
Pharmacokinetics and transcriptional effects of the anti-salmon lice drug emamectin benzoate in Atlantic salmon (Salmo salar L.) [0.03%]
乙苯咪隆在大西洋鲑鱼(Salmo salar L.)体内的药代动力学及转录效应
Pål A Olsvik,Kai K Lie,Eva Mykkeltvedt et al.
Pål A Olsvik et al.
Background: Emamectin benzoate (EB) is a dominating pharmaceutical drug used for the treatment and control of infections by sea lice (Lepeophtheirus salmonis) on Atlantic salmon (Salmo salar L). Fish with an initial mean ...
Methoxylation enhances stilbene bioactivity in Caenorhabditis elegans [0.03%]
甲氧基化增强茋类化合物在秀丽隐杆线虫中的生物活性
Mark A Wilson,Agnes M Rimando,Catherine A Wolkow
Mark A Wilson
Background: Stilbenes are 1,2-diphenylethylene congeners produced by plants in response to stress. Many stilbenes also exhibit xenobiotic activities in animal cells, such as inhibition of cancer cell growth, neuroprotecti...
Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats [0.03%]
阿托伐他汀和匹伐他汀改善L-蛋氨酸致大鼠血管性痴呆的积极作用研究
Rajeshkumar U Koladiya,Amteshwar S Jaggi,Nirmal Singh et al.
Rajeshkumar U Koladiya et al.
Background: Statins, HMG-CoA reductase inhibitors, are widely prescribed drugs for dyslipidemias. Recent studies have indicated number of cholesterol independent actions of statins including their beneficial effects on va...
A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores [0.03%]
基于蛋白质-药物对接分数的细胞毒混合物协同/拮抗效应分类模型
John C Boik,Robert A Newman
John C Boik
Background: Safer and more effective mixtures of anticancer drugs are needed, and modeling can assist in this endeavor. This paper describes classification models that were constructed to predict which fixed-ratio mixture...
Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compounds [0.03%]
口服清除、细胞毒性和LD50的构效模型：一项针对颇具潜力的抗肿瘤化合物的研究
John C Boik,Robert A Newman
John C Boik
Background: Quantitative structure-activity relationship (QSAR) models have become popular tools to help identify promising lead compounds in anticancer drug development. Few QSAR studies have investigated multitask learn...
Comparative Study
BMC pharmacology. 2008 Jun 13:8:12. DOI:10.1186/1471-2210-8-12 2008
Pharmacological Properties of DOV 315,090, an ocinaplon metabolite [0.03%]
DOV 315,090的药理性质研究(Ocinaplon的代谢产物)
Dmytro Berezhnoy,Maria C Gravielle,Scott Downing et al.
Dmytro Berezhnoy et al.
Background: Compounds targeting the benzodiazepine binding site of the GABAA-R are widely prescribed for the treatment of anxiety disorders, epilepsy, and insomnia as well as for pre-anesthetic sedation and muscle relaxat...
Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives [0.03%]
苯夫西明是一种合成的维生素S-酰衍生物，具有不同于脂溶性硫化衍生物的机制和药理学特征
Marie-Laure Volvert,Sandrine Seyen,Marie Piette et al.
Marie-Laure Volvert et al.
Background: Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. Benfotiamine (S-benzoylthiamine O-monophosphate), an amphiph...
Comparative Study
BMC pharmacology. 2008 Jun 12:8:10. DOI:10.1186/1471-2210-8-10 2008
Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells [0.03%]
Gi偶联的人组胺H3受体在CHO细胞中表达的拮抗剂亲和性测定
Jillian G Baker
Jillian G Baker
Background: The H3 histamine receptor is a Gi-coupled GPCR that has been proven to exist in different agonist-induced states, including that defined by the protean agonist proxyfan. Several GPCRs are now known to exist in...
Comparative Study
BMC pharmacology. 2008 Jun 6:8:9. DOI:10.1186/1471-2210-8-9 2008
Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line [0.03%]
四种不同比色和荧光细胞毒性检测方法在斑马鱼肝癌细胞系中比较研究
Stephanie K Bopp,Teresa Lettieri
Stephanie K Bopp
Background: A broad spectrum of cytotoxicity assays is currently used in the fields of (eco)toxicology and pharmacology. To choose an appropriate assay, different parameters like test compounds, detection mechanism, speci...
Comparative Study
BMC pharmacology. 2008 May 30:8:8. DOI:10.1186/1471-2210-8-8 2008