Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells [0.03%]
氟哌啶醇改变人类神经胶质瘤细胞中QKI剪接变异体的mRNA表达
Lin Jiang,Peter Saetre,Elena Jazin et al.
Lin Jiang et al.
Background: The quaking homolog, KH domain RNA binding (mouse) (QKI) is a candidate gene for schizophrenia. Disturbed QKI mRNA expression is observed in the prefrontal cortex of patients, and some of these changes correla...
Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats [0.03%]
单剂量口服给药后非甾体抗炎药diclofenac选择性蓄积到大鼠炎症组织中
A Schweitzer,N Hasler-Nguyen,J Zijlstra
A Schweitzer
Background: Diclofenac is a nonsteroidal anti-inflammatory drug which is available as prescription (RX) and over-the-counter (OTC) medication for the systemic and topical treatment of painful and inflammatory conditions s...
Bioinformatic characterizations and prediction of K+ and Na+ ion channels effector toxins [0.03%]
毒蛋白的生物信息学特征及钾离子通道和钠离子通道效应毒蛋白的预测研究
Rima Soli,Belhassen Kaabi,Mourad Barhoumi et al.
Rima Soli et al.
Background: K+ and Na+ channel toxins constitute a large set of polypeptides, which interact with their ion channel targets. These polypeptides are classified in two different structural groups. Recently a new structural ...
The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis [0.03%]
4%dimeticone搽剂对头虱(Pediculuscapitis)作用方式的研究
Ian F Burgess
Ian F Burgess
Background: Treatment of head lice using physically acting preparations based on silicones is currently replacing insecticide use due to widespread resistance to neurotoxic agents. It has been postulated that some product...
AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts [0.03%]
AICAR激活胚胎干细胞多能性基因表达网络并诱导成纤维细胞中KLF4和KLF2的表达
Luigi Adamo,Yuzhi Zhang,Guillermo García-Cardeña
Luigi Adamo
Background: Pluripotency, the property of a cell to differentiate into all cellular types of a given organism, is central to the development of stem cell-based therapies and regenerative medicine. Stem cell pluripotency i...
Conformational changes in alpha 7 acetylcholine receptors underlying allosteric modulation by divalent cations [0.03%]
二价阳离子通过别构位点调节α7烟碱型乙酰胆碱受体的机制研究
James T McLaughlin,Sean C Barron,Jennifer A See et al.
James T McLaughlin et al.
Allosteric modulation of membrane receptors is a widespread mechanism by which endogenous and exogenous agents regulate receptor function. For example, several members of the nicotinic receptor family are modulated by physiological concentr...
Abstracts of the 14th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Innsbruck, Austria. 21-22 November 21-22, 2008 [0.03%]
奥地利药理学会第十四届科学研讨会摘要总结_innsbruck，奥地利_2008年11月21-22日
Miroslav Radenković,Paja Momčilov,Nebojša Radunović et al.
Miroslav Radenković et al.
Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000 [0.03%]
咪唑喹啉类变构增强剂LUF6000调节人A3腺苷受体激动剂效能的灵活性
Zhan-Guo Gao,Kai Ye,Anikó Göblyös et al.
Zhan-Guo Gao et al.
Background: A series of 1H-imidazo- [4,5-c]quinolin-4-amine derivatives, represented by LUF6000 (N-(3,4-dichloro-phenyl)-2-cyclohexyl-1H-imidazo [4,5-c]quinolin-4-amine), are allosteric modulators of the human A3 adenosin...
Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1 [0.03%]
茋类衍生物可以抑制或增强佛波酯诱导的活化蛋白-1(AP-1)表达
Lorraine M Deck,Lucy A Hunsaker,Amanda M Gonzales et al.
Lorraine M Deck et al.
Background: The activator protein-1 (AP-1) family of transcription factors contributes to regulation of numerous genes involved in proliferation, apoptosis, and tumorigenesis. A wide array of stimuli can activate AP-1, in...
Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers [0.03%]
三项布洛芬制剂单次给药后的生物等效性研究
Peter Bramlage,Adrian Goldis
Peter Bramlage
Background: This phase I study was designed to determine the bioavailability and bioequivalence of 400 mg Eudorlin extra* (Ibuprofen) in comparison to two reference formulations (400 mg Nurofen forte and 400 mg Migränin ...
Clinical Trial
BMC pharmacology. 2008 Oct 29:8:18. DOI:10.1186/1471-2210-8-18 2008