Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands [0.03%]
正构调节剂和异构调节剂对胆碱能M₁受体的差异调控作用研究
Christopher N Davis,Stefania Risso Bradley,Hans H Schiffer et al.
Christopher N Davis et al.
Background: Activation of muscarinic M1 receptors is mediated via interaction of orthosteric agonists with the acetylcholine binding site or via interaction of allosteric agonists with different site(s) on the receptor. T...
Comparative Study
BMC pharmacology. 2009 Dec 2:9:14. DOI:10.1186/1471-2210-9-14 2009
Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway [0.03%]
スピペロネは細胞内カルシウム上昇とWnt信号伝達路の阻害を引き起こす
Desheng Lu,Dennis A Carson
Desheng Lu
Background: Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers and is...
Comparative Study
BMC pharmacology. 2009 Nov 30:9:13. DOI:10.1186/1471-2210-9-13 2009
Abstracts of the 15th Scientific Symposium of the Austrian Pharmacological Society (APHAR) joint meeting with the Hungarian Society of Experimental and Clinical Pharmacology (MFT) and the Slovenian Pharmacological Society (SDF). Graz, Austria. November 19-21, 2009 [0.03%]
奥地利药理学会（APHA）第十五届科学研讨会与匈牙利实验与临床药理学协会（MFT）和斯洛文尼亚药理学会（SDF)联合会议摘要.克恩顿州，格拉茨， Austria. 2009年11月19-21日
Peng Zhang,Radharaman Ray,Bal Ram Singh et al.
Peng Zhang et al.
Background: Botulinum neurotoxin (BoNT) is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses. An effective medical countermeasure strategy would require developing a d...
Comparative Study
BMC pharmacology. 2009 Oct 27:9:12. DOI:10.1186/1471-2210-9-12 2009
Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity [0.03%]
评估抗肿瘤药物的分子描述符及其与DNA非共价结合和抗增殖活性的关系
José Portugal
José Portugal
Background: Small molecules that bind reversibly to DNA are among the antitumor drugs currently used in chemotherapy. In the pursuit of a more rational approach to cancer chemotherapy based upon these molecules, it is nec...
Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells [0.03%]
精神活性药物可以上调人类CNS和肝细胞中胆固醇转运蛋白（包括ApoE）的表达
Audun O Vik-Mo,Johan Fernø,Silje Skrede et al.
Audun O Vik-Mo et al.
Background: Disturbances in lipid homeostasis and myelination have been proposed in the pathophysiology of schizophrenia and bipolar disorder. We have previously shown that several antipsychotic and antidepressant drugs i...
Abstracts of the 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications. Regensburg, Germany. June 19-21, 2009 [0.03%]
第4届环磷酸鸟苷生成物、效应器和治疗意义国际会议摘要 德国雷根斯堡大学 2009年6月19～21日
Najla Arshad,Sandhya S Visweswariah
Najla Arshad
A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen [0.03%]
基于聚焦的 beads-to- compounds 文库筛选得到RGS4的共价肽类抑制剂
Rebecca A Roof,David L Roman,Samuel T Clements et al.
Rebecca A Roof et al.
Background: Regulators of G protein signaling (RGSs) accelerate GTP hydrolysis by Galpha subunits and profoundly inhibit signaling by G protein-coupled receptors (GPCRs). The distinct expression patterns and pathophysiolo...
Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models [0.03%]
雷帕霉素维持剂量给药以及雷帕霉素联合索拉非尼但不是阿托伐他汀或多西环素治疗结节性硬化症的前期模型可能有效
Nancy Lee,Chelsey L Woodrum,Alison M Nobil et al.
Nancy Lee et al.
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by hamartomatous growths in the brain, skin, kidneys, lungs, and heart, which lead to significant morbidity. T...
N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes [0.03%]
N-乙酰半胱胺降低多柔比星在H9C2心肌细胞中诱发的氧化应激但不影响细胞死亡
Rong Shi,Chuan-Chin Huang,Robert S Aronstam et al.
Rong Shi et al.
Background: While doxorubicin (DOX) is widely used in cancer chemotherapy, long-term severe cardiotoxicity limits its use. This is the first report of the chemoprotective efficacy of a relatively new thiol antioxidant, N-...