Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice [0.03%]
五羟色胺转运蛋白敲除小鼠海马体中5-ht2c受体激动剂诱导的反应和5-ht2c受体rnA编辑的改变
Pablo R Moya,Meredith A Fox,Catherine L Jensen et al.
Pablo R Moya et al.
Background: The serotonin 5-HT2C receptor (5-HT2CR) is expressed in amygdala, a region involved in anxiety and fear responses and implicated in the pathogenesis of several psychiatric disorders such as acute anxiety and p...
Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro [0.03%]
雷沙吉兰、其代谢产物氨吲哚和司来吉兰对大鼠海马脑片中谷氨酸受体介导的信号转导的影响
W Dimpfel,J A Hoffmann
W Dimpfel
Background: Rasagiline, a new drug developed to treat Parkinson's disease, is known to inhibit monoamine oxidase B. However, its metabolite R-(-)-aminoindan does not show this kind of activity. The present series of in vi...
The boron-oxygen core of borinate esters is responsible for the store-operated calcium entry potentiation ability [0.03%]
硼氧核心是硼酸酯介导的钙离子入口通路扩张能力的关键因素
Olivier Dellis,Pierre Mercier,Christine Chomienne
Olivier Dellis
Background: Store-Operated Calcium Entry (SOCE) is the major Ca2+ ion entry pathway in lymphocytes and is responsible of a severe combined immunodeficiency (SCID) when deficient. It has recently been observed or highlight...
Abstracts of the 16th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Vienna, Austria. November 25-27, 2010 [0.03%]
奥地利药理学会第十六届科学研讨会摘要维也纳，奥地利. 2010年11月25日-27日
Julia Kargl,Nariman Balenga,Wolfgang Platzer et al.
Julia Kargl et al.
Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study [0.03%]
健康男性志愿者中两种聚乙二醇干扰素α-2剂型的药代动力学和药效学比较：随机、交叉、双盲研究
Idrian García-García,Carlos A González-Delgado,Carmen M Valenzuela-Silva et al.
Idrian García-García et al.
Background: Interferon (IFN) alpha conjugation to polyethylene glycol (PEG) results in a better pharmacokinetic profile and efficacy. The aim of this study was to compare the pharmacokinetic, pharmacodynamic and safety pr...
Clinical Trial
BMC pharmacology. 2010 Nov 23:10:15. DOI:10.1186/1471-2210-10-15 2010
Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice [0.03%]
索坦与扑热息痛相互作用的病理组织学和生化分析
Adeline Yl Lim,Ignacio Segarra,Srikumar Chakravarthi et al.
Adeline Yl Lim et al.
Background: Sunitinib, a tyrosine kinase inhibitor to treat GIST and mRCC may interact with paracetamol as both undergo P450 mediated biotransformation and P-glycoprotein transport. This study evaluates the effects of sun...
Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver [0.03%]
水鳖素natanssin对抗四氯化碳诱导的大鼠肝氧化应激和细胞退行性变的保护功效研究
Polimetla Srilaxmi,Gangadhara Reddy Sareddy,Polavarapu Bilhan Kavi Kishor et al.
Polimetla Srilaxmi et al.
Background: Carbon tetra chloride (CCl4), an industrial solvent, is a hepatotoxic agent and it is the well established animal model for free radical-induced liver injury. The present investigation was carried out to estab...
Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells [0.03%]
造血干细胞表达一种与其他干细胞明显不同的ABC转运蛋白基因谱型
Leilei Tang,Saskia M Bergevoet,Christian Gilissen et al.
Leilei Tang et al.
Background: ATP-binding cassette (ABC) transporters protect cells against unrelated (toxic) substances by pumping them across cell membranes. Earlier we showed that many ABC transporters are highly expressed in hematopoie...
Comparative Study
BMC pharmacology. 2010 Sep 13:10:12. DOI:10.1186/1471-2210-10-12 2010
Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia [0.03%]
agmatine对暂时性脑缺血后脑部凋亡、星形胶质细胞增生和水肿的有益作用
Che-Chuan Wang,Chung-Ching Chio,Ching-Hong Chang et al.
Che-Chuan Wang et al.
Background: Although agmatine therapy in a mouse model of transient focal cerebral ischemia is highly protective against neurological injury, the mechanisms underlying the protective effects of agmatine are not fully eluc...
Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling [0.03%]
salvianolic酸B作为基质金属蛋白酶-9的竞争性抑制剂有效预防心脏重构
Baohong Jiang,Jing Chen,Lingling Xu et al.
Baohong Jiang et al.
Background: Infarct-induced left ventricular (LV) remodeling is a deleterious consequence after acute myocardial infarction (MI) which may further advance to congestive heart failure. Therefore, new therapeutic strategies...