Inability of serotonin to activate the c-Jun N-terminal kinase and p38 kinase pathways in rat aortic vascular smooth muscle cells [0.03%]
5-羟色胺不能激活大鼠主动脉血管平滑肌细胞的c-Jun氨基末端激酶和p38丝裂原活化蛋白激酶途径
A K Banes,R D Loberg,F C Brosius rd et al.
A K Banes et al.
Background: Serotonin (5-HT, 5-hydroxytryptamine) activates the Extracellular Signal-Regulated Kinase (ERK)/ Mitogen-Activated Protein Kinase (MAPK) pathways, in vascular smooth muscle cells. Parallel MAPK pathways, the c...
Omapatrilat normalizes renal function curve in spontaneously hypertensive rats [0.03%]
奥马普利使自发性高血压大鼠的肾功能曲线恢复正常化
P Morazo,L A Fortepiani,M Clara Ortíz et al.
P Morazo et al.
Background: The present study was designed to analyze the chronic renal response to omapatrilat, a new vasopeptidase inhibitor, in spontaneously hypertensive rats (SHR). To that end, the renal and blood pressure response ...
Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats [0.03%]
奥氮平和利培酮对麻醉大鼠膀胱及尿道外括约肌功能的影响
P L Vera,A Miranda-Sousa,I Nadelhaft
P L Vera
Background: A previous report showed that the atypical neuroleptic clozapine resulted in marked changes in urodynamic parameters and greatly inhibited the activity of the external urethral sphincter in anesthetized rats. ...
Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract [0.03%]
Tabebuia avellanedae Lor. ex Griseb. 内树皮的水提物抗痛觉及抗炎作用和急性毒性研究
F G de Miranda,J C Vilar,I A Alves et al.
F G de Miranda et al.
Background: Tabebuia avellanedae is a tree from the Bignoniaceae family. Commonly know as "pau d'arco" in Brazil, its inner bark is used as analgesic, anti-inflammatory, antineoplasic and diuretic at the Brazilian northea...
Phorbol ester impairs electrical excitation of rat pancreatic beta-cells through PKC-independent activation of KATP channels [0.03%]
佛波酯通过PKC非依赖性激活KATP通道途径抑制大鼠胰岛β细胞的电兴奋性
S Suga,J Wu,Y Ogawa et al.
S Suga et al.
Background: Phorbol 12-myristate 13-acetate (PMA) is often used as an activating phorbol ester of protein kinase C (PKC) to investigate the roles of the kinase in cellular functions. Accumulating lines of evidence indicat...
The effect of GABA receptor ligands in experimental spina bifida occulta [0.03%]
实验性隐性脊柱裂中γ-氨基丁酸受体配体的作用
W Briner
W Briner
Background: The pathophysiology behind spina bifida and other neural tube defects (NTDs) is unclear. Folic acid is one variable, but other factors remain. Studies suggest that substances active at the GABA receptor may pr...
Flow cytometry analysis of the effect of allopurinol and the dinitroaniline compound (Chloralin) on the viability and proliferation of Leishmania infantum promastigotes [0.03%]
流式细胞术分析别嘌呤醇和二硝基苯胺类化合物（氯氯酚）对利什曼原鞭虫活力及增殖的影响
S W Kamau,R Nunez,F Grimm
S W Kamau
Background: Leishmaniasis is a major parasitic disease in the tropical regions. However, Leishmania infantum has recently emerged as a very important cause of opportunistic infections for individuals positive for human im...