Central effects of clozapine in regulating micturition in anesthetized rats [0.03%]
氯氮平调节麻醉大鼠排尿的中枢作用
Pedro L Vera,Alejandro J Miranda-Sousa,Raul C Ordorica et al.
Pedro L Vera et al.
Background: We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited the external urethral sphincter. Since clozapine acts a...
4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal [0.03%]
4-(N,N-二丙基氨基)苯甲醛通过抑制ALDH1A1的视黄醛氧化作用发挥抗肿瘤活性，但不影响全反式视黄醛诱导HL-60细胞分化
James Russo,Annette Barnes,Katie Berger et al.
James Russo et al.
Background: The signal transduction pathways mediated by retinoic acid play a critical role in the regulation of cell growth and differentiation during embryogenesis and hematopoiesis as well as in a variety of tumor cell...
Low molecular mass dinitrosyl nonheme-iron complexes up-regulate noradrenaline release in the rat tail artery [0.03%]
低分子量的二硝基非血红素铁化合物上调大鼠尾动脉去甲肾上腺素释放
Andrei L Kleschyov,Gilles Hubert,Thomas Munzel et al.
Andrei L Kleschyov et al.
Background: Dinitrosyl nonheme-iron complexes can appear in cells and tissues overproducing nitric oxide. It is believed that due to their chemical nature these species may be implicated in certain pathophysiological even...
Pharmacokinetics of artesunate after single oral administration to rats [0.03%]
单次口服双氢青蒿素后大鼠的药代动力学性质研究
P L Olliaro,N K Nair,K Sathasivam et al.
P L Olliaro et al.
Background: Artesunate is a commonly used antimalarial drug derived from artemisinin. It is rapidly converted to dihydroartemisinin. Little is known on this conversion in the GI tract and blood, and how this influences ab...
In vivo models of lung neutrophil activation. Comparison of mice and hamsters [0.03%]
肺中性粒细胞激活的活体模型。小鼠和哈姆斯特的比较
Randolph Corteling,Daniel Wyss,Alexandre Trifilieff
Randolph Corteling
Background: Evidence suggests that both the migration and activation of neutrophils into the airway is of importance in pathological conditions such as pulmonary emphysema. In the present study, we describe in vivo models...
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272 [0.03%]
类似YC-1和BAY 41-2272的直接sGC刺激剂的非NO依赖性调节位点
E M Becker,C Alonso-Alija,H Apeler et al.
E M Becker et al.
Background: The most important receptor for nitric oxide is the soluble guanylate cyclase (sGC), a heme containing heterodimer. Recently, a pyrazolopyridine derivative BAY 41-2272, structurally related to YC-1, was identi...
Receptorphin: a conserved peptide derived from the sequence of the opioid receptor, with opioid displacement activity and potent antiproliferative actions in tumor cells [0.03%]
阿片受体衍生的保守肽类物质receptorphin及其在肿瘤细胞中的解离和抗增殖作用
M Kampa,S Loukas,A Tsapis et al.
M Kampa et al.
Background: In addition to endogenous opioids, a number of peptide sequences, derived from endogenous (hemorphins, alphaS1-casomorphin), and exogenous proteins (casomorphins, exorphins) have been reported, possessing opio...
Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs [0.03%]
miniature猪的细胞色素P450 3A，2A和2C酶与人类类似物具有相似的特性
P Soucek,R Zuber,E Anzenbacherová et al.
P Soucek et al.
Background: The search for an optimal experimental model in pharmacology is recently focused on (mini)pigs as they seem not only to be an alternative source of cells and tissues for xenotherapy but also an alternative spe...
Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death [0.03%]
过氧化物酶体增殖激活受体激动剂能够预防25-羟基胆固醇诱导的c-jun活化和细胞死亡
J Y Chang,L Z Liu
J Y Chang
Background: Cholesterol oxides, the oxygenated derivatives of cholesterol, have been shown to cause programmed cell death in a variety of cell types. Using N9 microglia, this study was designed to investigate the molecula...
Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia [0.03%]
短期接触海洋毒素_domoin酸对大鼠新生小胶质细胞存活率_肿瘤坏死因子α_基质金属蛋白酶9和超氧阴离子释放的影响
A M Mayer,M Hall,M J Fay et al.
A M Mayer et al.
Background: The excitatory amino acid domoic acid, a glutamate and kainic acid analog, is the causative agent of amnesic shellfish poisoning in humans. No studies to our knowledge have investigated the potential contribut...