Youfei Guan,Brett A Stillman,Yahua Zhang et al.
Youfei Guan et al.
Background: Prostaglandin E2 (PGE2) has multiple physiologic roles mediated by G protein coupled receptors designated E-prostanoid, or "EP" receptors. Evidence supports an important role for the EP2 receptor in regulating...
In vitro susceptibility to pentavalent antimony in Leishmania infantum strains is not modified during in vitro or in vivo passages but is modified after host treatment with meglumine antimoniate [0.03%]
雷诺查米亚幼虫期对五价抗imonial的体外敏感性在体内外传代过程中不会改变，但宿主使用葡萄糖胺抗imonial治疗后会发生变化
Jaume Carrió,Montserrat Portús
Jaume Carrió
Background: Leishmaniasis is a common parasitic disease in Southern Europe, caused by Leishmania infantum. The failures of current treatment with pentavalent antimonials are partially attributable to the emergence of anti...
Seed germination, phenology, and antiedematogenic activity of Peperomia pellucida (L.) H. B. K [0.03%]
Peperomia pellucida (L.) H.B.K的发芽、物候及消肿作用研究
Maria de Fátima Arrigoni-Blank,Ricardo Luiz Barros Oliveira,Sandra Santos Mendes et al.
Maria de Fátima Arrigoni-Blank et al.
Background: Peperomia pellucida is popularly known as coraçãozinho in the Brazilian northeast and is used in the treatment of abscesses, furuncles, and conjunctivitis. Our work aimed to determine the term of the develop...
Selective alteration of gene expression in response to natural and synthetic retinoids [0.03%]
视黄醇和类似物对基因表达的诱导作用研究
Céline Brand,Pascaline Ségard,Pascal Plouvier et al.
Céline Brand et al.
Background: Retinoids are very potent inducers of cellular differentiation and apoptosis, and are efficient anti-tumoral agents. Synthetic retinoids are designed to restrict their toxicity and side effects, mostly by incr...
Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation [0.03%]
激活过氧化物酶体增殖活化受体α对心肌缺血损伤具有保护作用并改善内皮细胞血管舒张功能
Antonia Tabernero,Kristina Schoonjans,Laurence Jesel et al.
Antonia Tabernero et al.
Background: The peroxisome proliferator-activated receptor alpha (PPARalpha) plays an important role in the metabolism of lipoproteins and fatty acids, and seems to protect against the development of atherosclerosis. To e...
The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution [0.03%]
一种法尼基转移酶抑制剂RPR-130401不影响人类肿瘤细胞的放射敏感性，尽管该抑制剂可导致这些具有K-ras突变的细胞染色体倍性的大幅变化和核纤层B分布的变化
Frédérique Mégnin-Chanet,François Lavelle,Vincent Favaudon
Frédérique Mégnin-Chanet
Background: Growth inhibition by RPR-130401, a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human tumor cell lines (HCT-116, MiAPaCa-2...
Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop [0.03%]
α2C肾上腺素受体的下调：第三个胞浆环中的丝氨酸/苏氨酸基序的作用
Jean D Deupree,Claudia D Borgeson,David B Bylund
Jean D Deupree
Background: The mechanisms by which alpha-2 adrenergic receptors are down-regulated following chronic exposure to agonist are not well understood. Interestingly, the human alpha-2C receptor does not down-regulate, whereas...
Gilles Klopman,Aleksandr Sedykh
Gilles Klopman
Background: Parkinson's disease is caused by a dopamine deficiency state in the fore brain area. Dopamine receptor agonists, MAO-B inhibitors, and N-Methyl-D-Aspartate (NMDA) receptor antagonists are known to have antipar...
Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice [0.03%]
藏红花雌蕊和花瓣提取物的抗炎镇痛作用研究
Hossein Hosseinzadeh,Hani M Younesi
Hossein Hosseinzadeh
Background: Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-inflammatory activity of saffron extracts in mice. ...
Delta opioid activation of the mitogen-activated protein kinase cascade does not require transphosphorylation of receptor tyrosine kinases [0.03%]
δ型阿片受体激活MAP激酶途径不需要受体酪氨酸激酶的跨磷酸化作用
H Kenneth Kramer,Irma Onoprishvili,Matthew L Andria et al.
H Kenneth Kramer et al.
Background: In this study, we investigated the mechanism(s) by which delta opioids induce their potent activation of extracellular signal-regulated protein kinases (ERKs) in different cell lines expressing the cloned delt...