Hossein Hosseinzadeh,Marjan Nassiri Asl
Hossein Hosseinzadeh
Background: Carbenoxolone, as an antiulcer medicine, has some pharmacological properties such as: the inhibition of gap junctional (GJ) intercellular communication. In vitro studies have shown, carbenoxolone to abolish th...
The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa [0.03%]
血管紧张素Ⅱ受体类型2激动剂CGP 42112A刺激猪回肠粘膜一氧化氮的生成
Sara Ewert,Mats Laesser,Bernalt Johansson et al.
Sara Ewert et al.
Background: This study was conducted to elucidate if nitric oxide is released by the porcine jejunal mucosa upon selective stimulation of AT2 receptors and the possible involvement of iNOS, and to investigate the presence...
Activity of opioid ligands in cells expressing cloned mu opioid receptors [0.03%]
阿片受体激动剂在表达克隆μ型阿片受体细胞中的活性研究
Parham Gharagozlou,Hasan Demirci,J David Clark et al.
Parham Gharagozlou et al.
Background: The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a cell system expressing only mu opioid receptors. Receptor activation was assessed by measuri...
Comparative Study
BMC pharmacology. 2003 Jan 4:3:1. DOI:10.1186/1471-2210-3-1 2003
Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice [0.03%]
罗勒种子提取物对小鼠实验性胃黏膜损伤的影响
Hossein Hosseinzadeh,Gholam Reza Karimi,Maryam Ameri
Hossein Hosseinzadeh
Background: As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveole...
The spinal antinociceptive effects of cholinergic drugs in rats: receptor subtype specificity in different nociceptive tests [0.03%]
胆碱能药物在大鼠不同疼痛测试中的脊髓镇痛作用：受体亚型的特异性研究
Michael Lograsso,Ray Nadeson,Colin S Goodchild
Michael Lograsso
Background: Several studies have shown that muscarinic cholinergic agonists cause antinociception in humans and animals when given by both spinal and non-spinal parenteral routes. It is uncertain which subtype of muscarin...
Toxic cocaine- and convulsant-induced modification of forced swimming behaviors and their interaction with ethanol: comparison with immobilization stress [0.03%]
可卡因和致惊厥物质对强制游泳行为的毒性作用及其与乙醇的交互作用并与束缚应激进行比较
Tamaki Hayase,Yoshiko Yamamoto,Keiichi Yamamoto
Tamaki Hayase
Background: Swimming behaviors in the forced swimming test have been reported to be depressed by stressors. Since toxic convulsion-inducing drugs related to dopamine [cocaine (COC)], benzodiazepine [methyl 6,7-dimethoxy-4...
The enhancement of the hyperglycemic effect of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine by vitamin C in an animal model [0.03%]
维生素C增强S-硝基半胱氨酸和S-硝基乙酰青霉素胺高血糖效应的动物实验研究
Donovan McGrowder,Dalip Ragoobirsingh,Tara Dasgupta
Donovan McGrowder
Background: S-nitrosoglutathione (GSNO) and S-nitroso-N-acetlypenicillamine (SNAP) are two of the most common sources of nitric oxide (NO) in the biomedical field. Vitamin C has been known to accelerate the decomposition ...
Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells [0.03%]
神经元一氧化氮合酶与肾上腺素α1受体亚型在转染HEK-293细胞中的相互作用研究
Andre S Pupo,Kenneth P Minneman
Andre S Pupo
Background: The C-terminal four amino acids (GEEV) of human alpha1A-adrenergic receptors (ARs) have been reported to interact with the PDZ domain of neuronal nitric oxide synthase (nNOS) in a yeast two-hybrid system. The ...
Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury [0.03%]
大蒜慢性给药可保护心肌免受缺血再灌注引起的氧化应激损伤
Sanjay Kumar Banerjee,Amit Kumar Dinda,Subhash Chandra Manchanda et al.
Sanjay Kumar Banerjee et al.
Background: Oxidative stress plays a major role in the biochemical and pathological changes associated with myocardial ischemic-reperfusion injury (IRI). The need to identify agents with a potential for preventing such da...
Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes? [0.03%]
杀虫畏对蛙心房肌细胞迟缓外向钾电流的影响吗？
Martin-Pierre Sauviat,Anthony Colas,Nicole Pages
Martin-Pierre Sauviat
Background: The effects of lindane, a gamma-isomer of hexachlorocyclohexane, were studied on transmembrane potentials and currents of frog atrial heart muscle using intracellular microelectrodes and the whole cell voltage...