Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2 [0.03%]
挥发吸入麻醉药作用于α1β2γ2型γ-氨基丁酸受体的分子机制的突变分析研究
Roberta Siegwart,Karin Krähenbühl,Sachar Lambert et al.
Roberta Siegwart et al.
Background: Amino acids in the beta subunit contribute to the action of general anaesthetics on GABA(A) receptors. We have now characterized the phenotypic effect of two beta subunit mutations in the most abundant GABA(A)...
Arterial expression of 5-HT2B and 5-HT1B receptors during development of DOCA-salt hypertension [0.03%]
DOCA盐高血压发展过程中动脉5-HT2B和5-HT1B受体的表达变化研究
Amy K L Banes,Stephanie W Watts
Amy K L Banes
Background: 5-hydroxytryptamine (5-HT)2B and 5-HT1B receptors are upregulated in arteries from hypertensive DOCA-salt rats and directly by mineralocorticoids. We hypothesized that increased 5-HT2B and 5-HT1B receptor dens...
Phenelzine treatment increases transcription factor AP-2 levels in rat brain [0.03%]
酚苄明治疗增加大鼠脑转录因子AP-2水平
Mattias Damberg,Cecilia Berggård,Lars Oreland
Mattias Damberg
Background: The elevations of noradrenaline (NA) and serotonin (5-HT) levels in response to acute serotonin reuptake inhibitor (SSRI) or tricyclic antidepressant (TCA) exposure are not consistent with the time course for ...
Pharmacogenetic heterogeneity of transgene expression in muscle and tumours [0.03%]
肌肉和肿瘤中转基因表达的药物基因异质性
Pierre Lefesvre,Joline Attema,Dirk van Bekkum
Pierre Lefesvre
Background: Recombinant adenoviruses are employed to deliver a therapeutic transgene in the liver, muscle or tumour tissue. However, to rationalise this delivery approach, the factors of variation between individuals need...
Effect of thymol on kinetic properties of Ca and K currents in rat skeletal muscle [0.03%]
薄荷醇对大鼠骨骼肌钙电流和钾电流动力学特性的影响研究
Norbert Szentandrássy,Péter Szentesi,János Magyar et al.
Norbert Szentandrássy et al.
Background: Thymol is widely used as a general antiseptic and antioxidant compound in the medical practice and industry, and also as a stabilizer to several therapeutic agents, including halothane. Thus intoxication with ...
The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils [0.03%]
一种超氧化物歧化酶模拟物M40401对蒙古沙鼠脑缺血再灌注损伤的保护作用研究
Vincenzo Mollace,Michelangelo Iannone,Carolina Muscoli et al.
Vincenzo Mollace et al.
Background: Overproduction of free radical species has been shown to occur in brain tissues after ischemia-reperfusion injury. However, most of free radical scavengers known to antagonize oxidative damage (e.g. superoxide...
Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates [0.03%]
尼美舒利对兴奋性氨基酸所致大鼠脑匀浆氧化损伤的影响
Eduardo Candelario-Jalil,Olga Sonia León
Eduardo Candelario-Jalil
Background: The cyclooxygenase-2 inhibitor nimesulide is able to reduce kainate-induced oxidative stress in vivo. Here we investigate if this effect is mediated by the direct antioxidant properties of nimesulide using a w...
In vitro antileishmanial effects of antibacterial diterpenes from two Ethiopian Premna species: P. schimperi and P. oligotricha [0.03%]
两种埃塞俄比亚 Premna 植物的抗菌二萜类化合物的体外抗利什曼病作用：P. schimperi 和 P. oligotricha
Solomon Habtemariam
Solomon Habtemariam
Background: Three antibacterial diterpenes: (5R,8R,9S,10R)-12-oxo-ent-3,13(16)-clerodien-15-oic acid (1), 16-hydroxy-clerod-3,13(14)-diene-15,16-olide (2) and ent-12-oxolabda-8,13(16)-dien-15-oic acid (3) were previously ...
The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes [0.03%]
吉朋肝细胞中氟苯bufen代谢的立体选择性
Radim Kral,Lenka Skalova,Barbora Szotakova et al.
Radim Kral et al.
Background: Flobufen (F) is an original nonsteroidal anti-inflammatory drug with one center of chirality. 4-Dihydroflobufen (DHF), compound with two chiral centers, is the main metabolite of F in microsomes and cytosol in...
Malin Malmsjö,Mingyan Hou,William Pendergast et al.
Malin Malmsjö et al.
Background: Extracellular nucleotides play an important role in the regulation of vascular tone and may be involved in cerebral vasospasm after subarachnoidal haemorrhage. This study was designed to characterise the contr...