A novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness score [0.03%]
基于氨基酸定位适配分值的半胱天冬酶抑制肽评价及筛选新方法
Atsushi Yoshimori,Ryoko Takasawa,Sei-Ichi Tanuma
Atsushi Yoshimori
Background: Since caspases are key executioners of apoptosis in cases of severe diseases including neurodegenerative disorders such as Alzheimer's disease and Huntington's disease, and viral infection diseases such as AID...
15-deoxy-delta 12, 14-Prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress [0.03%]
15-脱氧-12,14-前列腺素J2防止氧化应激引起的活性氧生成和线粒体膜电位去极化
Tarun K Garg,Jason Y Chang
Tarun K Garg
Background: With the use of cultured human retinal pigment epithelial cells, we have previously described a number of cellular responses to oxidative stress caused by H2O2. We also demonstrated that the cytotoxicity cause...
Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster [0.03%]
抑制胰腺胆固醇酯酶可减少大鼠的胆固醇吸收
John E Heidrich,Linda M Contos,Lucy A Hunsaker et al.
John E Heidrich et al.
Background: Pancreatic cholesterol esterase has three proposed functions in the intestine: 1) to control the bioavailability of cholesterol from dietary cholesterol esters; 2) to contribute to incorporation of cholesterol...
Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment [0.03%]
过敏驱动的气道炎症小鼠模型中的性别差异及布地奈德治疗反应的比较
Randolph Corteling,Alexandre Trifilieff
Randolph Corteling
Background: Evidence suggests that gender differences exist in the severity of many immunological diseases and their response to glucocorticosteroid treatment. In this report, we have used a murine model of ovalbumin-indu...
Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig [0.03%]
Nigella sativa的水浸剂和捣碎剂对 Guinea Pig气管链可能的松弛作用机制
Mohammad H Boskabady,Batool Shirmohammadi,Parastoo Jandaghi et al.
Mohammad H Boskabady et al.
Background: In previous studies, the relaxant, anticholinergic (functional antagonism) and antihistaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the other mechanisms r...
Comparative Study
BMC pharmacology. 2004 Feb 25:4:3. DOI:10.1186/1471-2210-4-3 2004
Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts [0.03%]
雷公藤内酯通过诱导类风湿滑膜成纤维细胞凋亡而产生药效作用
Natsuko Kusunoki,Ryuta Yamazaki,Hidero Kitasato et al.
Natsuko Kusunoki et al.
Background: Extracts of Tripterygium wilfordii Hook F (TWHF), a traditional Chinese herb, have been reported to show efficacy in patients with rheumatoid arthritis (RA). Since RA is not only characterized by inflammation ...
Relationship between PPARalpha activation and NO on proximal tubular Na+ transport in the rat [0.03%]
PPARα活化与NO对大鼠近端肾小管钠转运的影响之间的关系
Mohammad A Newaz,Kasturi Ranganna,Adebayo O Oyekan
Mohammad A Newaz
Background: Nitric oxide (NO) regulates renal proximal tubular (PT) Na+ handling through modulation of Na+-K+ ATPase. Peroxisome Proliferator Activated Receptor alpha (PPARalpha), a nuclear transcription factor, is expres...
Protection against acute adriamycin-induced cardiotoxicity by garlic: role of endogenous antioxidants and inhibition of TNF-alpha expression [0.03%]
大蒜对急性阿霉素致心肌毒性的保护作用：内源性抗氧化剂和抑制TNF-α表达的作用
Sumanta Mukherjee,Sanjay Kumar Banerjee,Mohua Maulik et al.
Sumanta Mukherjee et al.
Background: Oxidative stress is the major etiopathological factor in adriamycin-induced cardiotoxicity. Relatively low amounts of endogenous antioxidant makes the heart vulnerable to oxidative stress-induced damage. Chron...
Enhanced beta2-adrenergic receptor (beta2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer [0.03%]
利用腺相关病毒介导的基因转移增强β2肾上腺素能受体信号转导
Stacie M Jones,F Charles Hiller,Sandie E Jacobi et al.
Stacie M Jones et al.
Background: Beta2-adrenergic receptors (beta2AR) play important regulatory roles in a variety of cells and organ systems and are important therapeutic targets in the treatment of airway and cardiovascular disease. Prolong...
Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening [0.03%]
半胱氨酸突变体增强μ阿片受体自发活性的机制及其作为筛选非激动剂工具的研究
Karl Brillet,Brigitte L Kieffer,Dominique Massotte
Karl Brillet
Background: The concept of spontaneous- or constitutive-activity has become widely accepted and verified for numerous G protein-coupled receptors and this ligand-independent activity is also acknowledged to play a role in...