The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1 [0.03%]
氨基胍羧酸盐BVT.12777激活胰岛素瘤细胞系CRI-G1的ATP敏感性K+通道
Jackie M Kinsella,Hilary A Laidlaw,Teresa Tang et al.
Jackie M Kinsella et al.
Background: 3-guanidinopropionic acid derivatives reduce body weight in obese, diabetic mice. We have assessed whether one of these analogues, the aminoguanidine carboxylate BVT.12777, opens KATP channels in rat insulinom...
Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors [0.03%]
外在因素调节strychnine敏感性甘氨酸受体的部分激动作用效力
Jeffrey S Farroni,Brian A McCool
Jeffrey S Farroni
Background: Strychnine-sensitive glycine receptors in many adult forebrain regions consist of alpha2 + beta heteromeric channels. This subunit composition is distinct from the alpha1 + beta channels found throughout the a...
Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells [0.03%]
蛋白酶体抑制剂对培养细胞花生四烯酸释放及大鼠肝细胞花生四烯酸代谢的影响
Lawrence Levine
Lawrence Levine
Background: I have postulated that arachidonic acid release from rat liver cells is associated with cancer chemoprevention. Since it has been reported that inhibition of proteasome activities may prevent cancer, the effec...
A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats [0.03%]
一项比较加巴喷丁和普瑞巴林对新生大鼠培养背根神经节神经元电生理特性影响的研究
David McClelland,Rhian M Evans,Louise Barkworth et al.
David McClelland et al.
Background: Gabapentin and pregabalin have wide-ranging therapeutic actions, and are structurally related to the inhibitory neurotransmitter GABA. Gabapentin, pregablin and GABA can all modulate voltage-activated Ca2+ cha...
Comparative Study
BMC pharmacology. 2004 Aug 4:4:14. DOI:10.1186/1471-2210-4-14 2004
8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D3-induced growth inhibition without affecting 1,25-dihydroxyvitamin D3-stimulated differentiation of primary mouse epidermal keratinocytes [0.03%]
8-氯腺苷增强1,25-二羟基维生素D3诱导的小鼠初级表皮角质形成细胞生长抑制而不影响1,25-二羟基维生素D3刺激的分化
Wendy B Bollag,Xiaofeng Zhong,Sarah Josephson
Wendy B Bollag
Background: Epidermal keratinocytes continuously proliferate and differentiate to form the mechanical and water permeability barrier that makes terrestrial life possible. In certain skin diseases, these processes become d...
A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation [0.03%]
一种蛋白酶激活受体-2(PAR-2)激动肽tc-LIGRLO-NH2诱导肥大细胞释放蛋白酶并参与TNF降解
Hashem N Alshurafa,Grant R Stenton,John L Wallace et al.
Hashem N Alshurafa et al.
Background: Mast cell (MC)-derived serine proteases have been implicated in a variety of inflammatory processes. We have previously shown that rat peritoneal MC (PMC) express mRNA for protease activated receptor 2 (PAR-2)...
Niels Bindslev
Niels Bindslev
Background: Bell-shaped and terraced dose-response relations have been observed in single ligand application for enzymes, carriers, transporters, G protein-coupled receptors as well as for other receptive units. It seems ...
EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis [0.03%]
EMD273316及EMD95833（第四型磷酸二酯酶抑制剂）能通过直接抑制PDE4以及诱导内源性前列腺素生成促进骨髓细胞成纤维细胞集落的形成
Andrew Scutt,Norbert Beier,Claus Fittschen
Andrew Scutt
Background: Type 4 phosphodiesterase (PDE4) inhibitors have been shown to stimulate bone formation in vivo and to stimulate osteoblastic differentiation in vitro. As one possible mechanism for the stimulation of bone form...
Hypoglycemic and anti-lipemic effects of the aqueous extract from Cissus sicyoides [0.03%]
Cissus sicyoides的水提取物抗低血糖和抗脂质异常效应研究
Glauce S B Viana,Ana Carolina C Medeiros,Ana Michelle R Lacerda et al.
Glauce S B Viana et al.
Background: Cissus sicyoides (Vitaceae) is a medicinal plant popularly known in Brazil as "cipó-pucá, anil-trepador, cortina, and insulina". The plant is used in several diseases, including rheumatism, epilepsy, stroke ...
Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene [0.03%]
人滤泡淋巴瘤细胞系中吉西他滨耐药性由于脱氧胞苷激酶基因的部分缺失所致
Carlos María Galmarini,Marilyn L Clarke,Lars Jordheim et al.
Carlos María Galmarini et al.
Background: Gemcitabine is an analogue of deoxycytidine with activity against several solid tumors. In order to elucidate the mechanisms by which tumor cells become resistant to gemcitabine, we developed the resistant sub...
Comparative Study
BMC pharmacology. 2004 May 24:4:8. DOI:10.1186/1471-2210-4-8 2004