Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats [0.03%]
雷巴菌叶原花青素对大鼠卡拉胶致急性炎症反应的抑制作用
Nancy Garbacki,Monique Tits,Luc Angenot et al.
Nancy Garbacki et al.
Background: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats. ...
Weight loss dynamics during combined fluoxetine and olanzapine treatment [0.03%]
氟西汀和奥氮平联合治疗过程中的体重变化动力学规律
Jennifer A Perrone,Janet M Chabla,Brian H Hallas et al.
Jennifer A Perrone et al.
Background: Fluoxetine and olanzapine combination therapy is rapidly becoming an effective strategy for managing symptoms of treatment-resistant depression. Determining drug-drug interactions, drug metabolism and pharmaco...
Robert Kinobe,Yanbin Ji,Kanji Nakatsu
Robert Kinobe
Background: Endogenous nitric oxide (NO) and carbon monoxide (CO) are generated by nitric oxide synthase and heme oxygenase, respectively. Like NO, CO has been accepted as an important cellular signaling molecule in biolo...
Reduced inhibitory action of a GABAB receptor agonist on [3H]-dopamine release from rat ventral tegmental area in vitro after chronic nicotine administration [0.03%]
慢性尼古丁给药减少烟碱受体在伏膈核多巴胺能神经元中的表达及其对GABA_B受体激动剂抑制多巴胺释放作用的影响
Diana Amantea,Norman G Bowery
Diana Amantea
Background: The activation of GABAB receptors in the ventral tegmental area (VTA) has been suggested to attenuate the rewarding properties of psychostimulants, including nicotine. However, the neurochemical mechanism that...
Serum adiponectin as a biomarker for in vivo PPARgamma activation and PPARgamma agonist-induced efficacy on insulin sensitization/lipid lowering in rats [0.03%]
血清脂连素是体内PPARγ活化的生物标志物以及PPARγ激动剂对胰岛素增敏及降低血脂有效性的大鼠模型研究
Baichun Yang,Kathleen K Brown,Lihong Chen et al.
Baichun Yang et al.
Background: PPARgamma agonists ameliorate insulin resistance and dyslipidemia in type 2 diabetic patients. Adiponectin possesses insulin sensitizing properties, and predicts insulin sensitivity of both glucose and lipid m...
Nicolle H R Litjens,Elisabeth van Strijen,Co van Gulpen et al.
Nicolle H R Litjens et al.
Background: Psoriasis is a chronic inflammatory skin disease that can be successfully treated with a mixture of fumaric acid esters (FAE) formulated as enteric-coated tablets for oral use. These tablets consist of dimethy...
In vitro evaluation of the potential role of sulfite radical in morphine-associated histamine release [0.03%]
美沙酮通过组胺能机制诱发心动过速的作用研究
Emma M Gordon,Carolyn Myers,Jeffrey Blumer
Emma M Gordon
Background: Intravenous morphine use is associated with elevated histamine release leading to bronchoconstriction, edema and hemodynamic instability in some patients. This study evaluated the possibility that sulfite, whi...
Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats [0.03%]
过氧亚硝酸根解毒催化剂改善顺铂致大鼠肾毒性的肾脏损伤和蛋白质硝化作用
Yolanda I Chirino,Rogelio Hernández-Pando,José Pedraza-Chaverrí
Yolanda I Chirino
Background: Oxidative stress is involved in cisplatin-nephrotoxicity. However, it has not completely established if reactive nitrogen species and nitrosative stress are involved in this experimental model. The purpose of ...
The FK506 binding protein 13 kDa (FKBP13) interacts with the C-chain of complement C1q [0.03%]
FK506结合蛋白13kDa(FKBP13)与补体C1q的C链相互作用
Holger Neye,Eugen J Verspohl
Holger Neye
Background: The pharmacological action of specific immunosuppressants is mediated by immunophilins. While cyclosporin A binds to cyclophilins, FK506/tacrolimus, rapamycin, and others bind to FK506 binding proteins (FKBPs)...
Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans [0.03%]
绿茶对糖尿病小鼠血糖水平及血清蛋白模式的影响以及对健康人体葡萄糖代谢的影响
Hiroshi Tsuneki,Mitsuyo Ishizuka,Miki Terasawa et al.
Hiroshi Tsuneki et al.
Background: Green tea is widely consumed in Asian countries and is becoming increasingly popular in Western countries. Epidemiologically, it has been suggested that green tea consumption prevents type 2 diabetes. The pres...