Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs - method development and application to magnesium in sheep [0.03%]
药理动力学-药物动力学模型对绵羊镁的心血管效应的方法构建及应用研究
Richard N Upton,Guy L Ludbrook
Richard N Upton
Background: There have been few reports of pharmacokinetic models that have been linked to models of the cardiovascular system. Such models could predict the cardiovascular effects of a drug under a variety of circumstanc...
Synnöve Lindemalm,Radojka M Savic,Mats O Karlsson et al.
Synnöve Lindemalm et al.
Background: The nucleoside analog cladribine is used for the treatment of a variety of indolent B- and T-cell lymphoid malignancies. The primary aim of the study was to evaluate the population distribution of pharmacokine...
Cross-talk between phosphatidic acid and ceramide during ethanol-induced apoptosis in astrocytes [0.03%]
乙醇诱导的星形胶质细胞凋亡过程中磷脂酸与鞘氨醇-1-磷酸的串话作用
Beate Schatter,Shenchu Jin,Konrad Löffelholz et al.
Beate Schatter et al.
Background: Ethanol inhibits proliferation in astrocytes, an effect that was recently linked to the suppression of phosphatidic acid (PA) formation by phospholipase D (PLD). The present study investigates ethanol's effect...
Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney [0.03%]
柑橘生物类黄酮柚皮素可降低四氯化碳引起的大鼠肝脏和肾脏氧化应激水平
Naveen Tirkey,Sangeeta Pilkhwal,Anurag Kuhad et al.
Naveen Tirkey et al.
Background: CCl4 is a well-established hepatotoxin inducing liver injury by producing free radicals. Exposure to CCl4 also induces acute and chronic renal injuries. The present study was designed to establish the protecti...
Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram [0.03%]
酚普拉明而非氟西丁影响大鼠脑干转录因子AP-2的表达水平
Cecilia Berggard,Mattias Damberg,Lars Oreland
Cecilia Berggard
Background: Before therapeutic effect is obtained after treatment with antidepressant drugs, like serotonin selective reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAO-Is)...
Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo [0.03%]
两种茋二氧哌嗪化合物的抗肺癌作用及机制研究
Da-Yong Lu,Bin Xu,Jian Ding
Da-Yong Lu
Background: Probimane (Pro), an anti-cancer agent originating in China, was derived from razoxane (ICRF-159, Raz), a drug created in Britain, specifically targeting at cancer metastasis and as a cardioprotectant of anthro...
Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells [0.03%]
拓扑异构酶II导向的双二氧哌嗪类抗肿瘤药物ICRF-187（ IDX 187）在酵母和哺乳动物细胞中诱导的细胞毒性和DNA损伤表征
Lars H Jensen,Marielle Dejligbjerg,Lasse T Hansen et al.
Lars H Jensen et al.
Background: Bisdioxopiperazine anti-cancer agents are inhibitors of eukaryotic DNA topoisomerase II, sequestering this protein as a non-covalent protein clamp on DNA. It has been suggested that such complexes on DNA repre...
Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats [0.03%]
巴卡普林甲硝酸盐小鼠和大鼠的中枢神经系统作用及对儿茶酚胺代谢的影响研究
Satyanarayana Sreemantula,Krishna M Boini,Srinivas Nammi
Satyanarayana Sreemantula
Background: Reserpine, an alkaloid from Rauwolfia serpentina was widely used for its antihypertensive action in the past. In later years, its use has been reduced because of precipitation of depression and extra pyramidal...
Effect of dietary palm olein oil on oxidative stress associated with ischemic-reperfusion injury in isolated rat heart [0.03%]
棕榈油对缺血-再灌注损伤大鼠离体心脏氧化应激的影响
Deepak Narang,Subeena Sood,Mathew Kadali Thomas et al.
Deepak Narang et al.
Background: Palm olein oil (PO), obtained from refining of palm oil is rich in monounsaturated fatty acid and antioxidant vitamins and is widely used as oil in diet in many parts of the world including India. Palm oil has...
Long-term age-dependent behavioral changes following a single episode of fetal N-methyl-D-Aspartate (NMDA) receptor blockade [0.03%]
一次性宫内阻断N-甲基-D天冬氨酸(NMDA)受体导致的长期年龄依赖性行为变化
G Andrew Mickley,Cynthia L Kenmuir,Colleen A McMullen et al.
G Andrew Mickley et al.
Background: Administration of the N-methyl-D-aspartate (NMDA) antagonist ketamine during the perinatal period can produce a variety of behavioral and neuroanatomical changes. Our laboratory has reported reliable changes i...