Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions [0.03%]
不同膀胱测压条件下氧氟沙星和托特罗定在清醒及麻醉大鼠的尿动力学作用研究
Patrizia Angelico,Cristina Velasco,Luciano Guarneri et al.
Patrizia Angelico et al.
Background: Antimuscarinic agents are the most popular treatment for overactive bladder and their efficacy in man is well documented, producing decreased urinary frequency and an increase in bladder capacity. During cysto...
In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine [0.03%]
第三代表皮生长因子拮抗剂地氯雷他定的体内抗胆碱作用
G Howell rd,L West,C Jenkins et al.
G Howell rd et al.
Background: Muscarinic receptor mediated adverse effects, such as sedation and xerostomia, significantly hinder the therapeutic usefulness of first generation antihistamines. Therefore, second and third generation antihis...
Tetrandrine and thapsigargin release arachidonic acid from cells in culture and stimulate prostacyclin production in rat liver cells, but may do so by different pathways [0.03%]
四氢东莨菪碱和毒胡萝卜素释放培养细胞中的花生四烯酸并刺激大鼠肝细胞的前列环素生成，但可能通过不同的途径发挥作用
Lawrence Levine
Lawrence Levine
Background: Tetrandrine inhibits tumor cell proliferation and demonstrates chemoprevention in cancer models. Speculation on the association between its effects on K+ and Ca2+ channels and cancer chemoprevention has been m...
Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase, alterations in hyperammonemia [0.03%]
长期长时程增强在海马体内涉及可溶性鸟苷酸环化酶、蛋白激酶和cGMP降解磷酸二酯酶的顺序激活以及血氨升高引起的改变
Pilar Monfort,Vicente Felipo
Pilar Monfort
Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines [0.03%]
probation和MST-16通过细胞周期G2/M期停滞及阻断染色体排列抑制人类肿瘤细胞系增殖作用
Da Yong Lu,Min Huang,Cheng Hui Xu et al.
Da Yong Lu et al.
Background: Anticancer bisdioxopiperazines, including ICRF-154, razoxane (Raz, ICRF-159) and ICRF-193, are a family of anticancer agents developed in the UK, especially targeting metastases of neoplasms. Two other bisdiox...
Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T [0.03%]
西地那非使大鼠心脏环磷酸鸟苷含量增加，减少异丙肾上腺素引起的心肌肥厚反应及心肌激酶和肌钙蛋白T的释放
Madiha A H Hassan,Amal F Ketat
Madiha A H Hassan
Background: Cardiac hypertrophy is a major risk factor for morbidity and mortality in a number of cardiovascular diseases. Consequently, the signaling pathways that inhibit cardiac hypertrophy are currently receiving much...
Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats [0.03%]
雄激素替代或去势持续时间对清醒大鼠血压感受性心动过缓的影响
Gregg R Ward,Abdel A Abdel-Rahman
Gregg R Ward
Background: In this study, we tested the hypothesis that 17beta-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported inc...
Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport [0.03%]
第一代和第二代抗组胺药对胆碱能诱导的粘液细胞离子转运的影响
Huiling Liu,Jerry M Farley
Huiling Liu
Background: The first generation antihistamines, such as diphenhydramine, are fairly potent muscarinic antagonists in addition to being H1 selective antihistamines. The antimuscarinic action is often not desirable since i...
Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity [0.03%]
低剂量二十二碳六烯酸可保护正常结肠上皮细胞免受阿糖胞苷的毒性损伤
Ming C Cha,Angela Lin,Kelly A Meckling
Ming C Cha
Background: The nucleoside analogue arabinosylcytosine (araC) has been used for many years in the treatment of acute leukemia. Evidence in the literature suggests that araC may inhibit the growth of human colon carcinoma ...
Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines [0.03%]
海洋Manzamines类生物碱对小胶质细胞超氧阴离子和血栓素B2生成的调节作用差异性研究
Alejandro M S Mayer,Mary L Hall,Sean M Lynch et al.
Alejandro M S Mayer et al.
Background: Thromboxane B2 (TXB2) and superoxide anion (O2-) are neuroinflammatory mediators that appear to be involved in the pathogenesis of several neurodegenerative diseases. Because activated-microglia are the main s...