Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding [0.03%]
鉴定特定降钙素样受体氨基酸残基对血管活性肠肽高亲和力结合的重要性
Sugato Banerjee,Janel Evanson,Erik Harris et al.
Sugato Banerjee et al.
Background: Calcitonin gene-related peptide (CGRP) is a vasoactive neuropeptide whose biological activity has potential therapeutic value for many vascular related diseases. CGRP is a 37 amino acid neuropeptide that signa...
Mark Evan Goldman,Lynne Cregar,Dominique Nguyen et al.
Mark Evan Goldman et al.
Background: Anthrax is a human disease that results from infection by the bacteria, Bacillus anthracis and has recently been used as a bioterrorist agent. Historically, this disease was associated with Bacillus spore expo...
Cyclooxygenase expression is not required for release of arachidonic acid from cells by some nonsteroidal anti-inflammatory drugs and cancer preventive agents [0.03%]
一些非甾体抗炎药和化学预防剂释放细胞花生四烯酸不需要环氧化酶的表达
Lawrence Levine
Lawrence Levine
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to be effective in inhibiting colorectal cancer. Cyclooxygenase activity is thought to mediate, in part, this cancer preventive effect. From observ...
Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs [0.03%]
人和小鼠单胺转运蛋白对精神兴奋剂药物敏感性的比较研究
Dawn D Han,Howard H Gu
Dawn D Han
Background: The plasma membrane neurotransmitter transporters terminate neurotransmissions by the reuptake of the released neurotransmitters. The transporters for the monoamines dopamine, norepinephrine, and serotonin (DA...
Comparative Study
BMC pharmacology. 2006 Mar 3:6:6. DOI:10.1186/1471-2210-6-6 2006
Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression [0.03%]
p38丝裂原活化蛋白激酶抑制剂增强c-Jun氨基末端激酶活性：在诱导型一氧化氮合酶表达中的作用意义
Aleksi Lahti,Outi Sareila,Hannu Kankaanranta et al.
Aleksi Lahti et al.
Background: Nitric oxide (NO) is an inflammatory mediator, which acts as a cytotoxic agent and modulates immune responses and inflammation. p38 mitogen-activated protein kinase (MAPK) signal transduction pathway is activa...
Comparative Study
BMC pharmacology. 2006 Feb 21:6:5. DOI:10.1186/1471-2210-6-5 2006
Effect of insulin on small intestinal transit in normal mice is independent of blood glucose level [0.03%]
胰岛素对正常小鼠小肠转运的影响独立于血糖水平
Peddyreddy Murali Krishna Reddy,Steven Aibor Dkhar,Ramaswamy Subramanian
Peddyreddy Murali Krishna Reddy
Background: Insulin is the drug of choice in the management of diabetes mellitus (DM). About 76 % of diabetic patients suffer from gastrointestinal (GI) disorders. Therapy of DM with insulin primarily involves lowering of...
Parham Gharagozlou,Ezzat Hashemi,Timothy M DeLorey et al.
Parham Gharagozlou et al.
Background: The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse kappa-opioid receptors. ...
Comparative Study
BMC pharmacology. 2006 Jan 25:6:3. DOI:10.1186/1471-2210-6-3 2006
Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats [0.03%]
去势和雄激素受体阻断可减轻清醒大鼠的血压反射介导的心动过缓
Gregg R Ward,Abdel A Abdel-Rahman
Gregg R Ward
Background: Previous studies have shown that testosterone enhances baroreflex bradycardia. Therefore, conscious unrestrained rats were used to investigate the role of the androgen receptor in the testosterone-mediated mod...
Comparative Study
BMC pharmacology. 2006 Jan 23:6:2. DOI:10.1186/1471-2210-6-2 2006
Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes [0.03%]
ε和θ亚基对非洲爪蟾卵母细胞表达的α3β1GABA受体药理学性质的影响
Martin Ranna,Saku T Sinkkonen,Tommi Möykkynen et al.
Martin Ranna et al.
Background: Gamma-aminobutyric acid type A (GABAA) receptors provide the main inhibitory control in the brain. Their heterogeneity may make it possible to precisely target drug effects to selected neuronal populations. In...
Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys [0.03%]
姜黄素对环孢菌素所致大鼠肾脏功能障碍和氧化应激的抑制作用研究
Naveen Tirkey,Gaganjit Kaur,Garima Vij et al.
Naveen Tirkey et al.
Background: In India, Curcumin (CMN) is popularly known as "Haldi", and has been well studied due to its economic importance. Traditional Indian medicine claims the use of its powder against biliary disorders, anorexia, c...