Clofibrate treatment in pigs: effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents [0.03%]
氯贝丁酯治疗对猪体内与啮齿类动物肝细胞癌发生有关的过氧化物酶体增殖参数的影响
Sebastian Luci,Beatrice Giemsa,Gerd Hause et al.
Sebastian Luci et al.
Background: In rodents treatment with fibrates causes hepatocarcinogenesis, probably as a result of oxidative stress and an impaired balance between apoptosis and cell proliferation in the liver. There is some debate whet...
The enantiomers of tramadol and its major metabolite inhibit peristalsis in the guinea pig small intestine via differential mechanisms [0.03%]
曲马多及其主要代谢产物的手性异构体通过不同的机制抑制 Guinea Pig 小肠的蠕动现象
Michael K Herbert,Rebecca Weis,Peter Holzer
Michael K Herbert
Background: Inhibition of intestinal peristalsis is a major side effect of opioid analgesics. Although tramadol is an opioid-like analgesic, its effect on gut motility is little known. Therefore, the effect of (+)-tramado...
Comparative Study
BMC pharmacology. 2007 Mar 16:7:5. DOI:10.1186/1471-2210-7-5 2007
In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate [0.03%]
在大鼠中，口服油酰-DHEA被迅速水解并转化为DHEA-硫酸盐
Marta Serrano,Maria del Mar Grasa,José Antonio Fernández-López et al.
Marta Serrano et al.
Background: Dehydroepiandrosterone (DHEA) released by adrenal glands may be converted to androgens and estrogens mainly in the gonadal, adipose, mammary, hepatic and nervous tissue. DHEA is also a key neurosteroid and has...
Gina L Quirarte,Larry D Reid,I Sofía Ledesma de la Teja et al.
Gina L Quirarte et al.
Background: An injection of estradiol valerate (EV) provides estradiol for a prolonged period. Recent research indicates that a single 2.0 mg injection of EV modifies a female rat's appetite for alcoholic beverages. This ...
Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions [0.03%]
β3含GABAA受体在吸入和静脉全身麻醉作用中的贡献映射图
Anja Zeller,Margarete Arras,Rachel Jurd et al.
Anja Zeller et al.
Background: Agents belonging to diverse chemical classes are used clinically as general anesthetics. The molecular targets mediating their actions are however still only poorly defined. Both chemical diversity and substan...
Comparative Study
BMC pharmacology. 2007 Feb 24:7:2. DOI:10.1186/1471-2210-7-2 2007
A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones [0.03%]
一种海洋海绵来源的烷基吡啶𬭩盐及其合成类似物对培养的大鼠海马神经元的作用机制比较研究
David J Koss,Kathleen P Hindley,Kanola C David et al.
David J Koss et al.
Background: Polymeric alkylpyridinium salts (poly-APS), are chemical defences produced by marine sponges including Reniera sarai. Poly-APS have previously been shown to effectively deliver macromolecules into cells. The e...
Comparative Study
BMC pharmacology. 2007 Feb 2:7:1. DOI:10.1186/1471-2210-7-1 2007
Inhibition of PKC activity blocks the increase of ETB receptor expression in cerebral arteries [0.03%]
PKC活性抑制可阻断脑动脉ETB受体表达的增加
Marie Henriksson,Petter Vikman,Emelie Stenman et al.
Marie Henriksson et al.
Background: Previous studies have shown that there is a time-dependent upregulation of contractile endothelin B (ETB) receptors in middle cerebral arteries (MCA) after organ culture. This upregulation is dependent on mito...
6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant [0.03%]
6-姜酚减少完全弗氏佐剂诱导的大鼠膝关节慢性炎性反应
Arkene Sa Levy,Oswald Simon,Janet Shelly et al.
Arkene Sa Levy et al.
Background: 6-Shogaol is one of the major compounds in the ginger rhizome that may contribute to its anti-inflammatory properties. Confirmation of this contribution was sought in this study in Sprague- Dawley rats (200-25...
Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis [0.03%]
一类新型多巴胺/5-ht2a受体作用的二苯并氮杂卓类化合物及其三维定量结构活性关系研究
Alexandra Hamacher,Mathias Weigt,Michael Wiese et al.
Alexandra Hamacher et al.
Background: Antipsychotics are divided into typical and atypical compounds based on clinical efficacy and side effects. The purpose of this study was to characterize in vitro a series of novel azecine-type compounds at hu...
Comparative Study
BMC pharmacology. 2006 Sep 15:6:11. DOI:10.1186/1471-2210-6-11 2006
A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones [0.03%]
从红海软珊瑚中获得的一种吡啶衍生物抑制了大鼠培养感觉神经元的电压激活式钾电导并增加其兴奋性
Tarek A Temraz,Wael E Houssen,Marcel Jaspars et al.
Tarek A Temraz et al.
Background: Whole cell patch clamp recording and intracellular Ca2+ imaging were carried out on rat cultured dorsal root ganglion (DRG) neurones to characterize the actions of crude extracts and purified samples from Red ...
Comparative Study
BMC pharmacology. 2006 Jul 6:6:10. DOI:10.1186/1471-2210-6-10 2006