Coordinate regulation of RARgamma2, TBP, and TAFII135 by targeted proteolysis during retinoic acid-induced differentiation of F9 embryonal carcinoma cells [0.03%]
特异性蛋白水解在视黄酸诱导的F9胚胎癌细胞分化过程中对RARγ2、TBP和TAFⅡ135的协调调节作用
L Perletti,E Kopf,L Carré et al.
L Perletti et al.
Background: Treatment of mouse F9 embryonal carcinoma cells with all-trans retinoic acid (T-RA) induces differentiation into primitive endodermal type cells. Differentiation requires the action of the receptors for all tr...
UAG readthrough in mammalian cells: effect of upstream and downstream stop codon contexts reveal different signals [0.03%]
哺乳动物细胞中的UAG终止密码子读通：上游和下游终止密码子的寡核苷酸环境对其效率的影响
M Cassan,J P Rousset
M Cassan
Background: Translation termination is mediated through an interaction between the release factors eRF1 and eRF3 and the stop codon within its nucleotide context. Although it is well known that the nucleotide contexts bot...
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice [0.03%]
Pten缺陷促进MMTV-Wnt-1转基因小鼠乳腺肿瘤发生
Y Li,K Podsypanina,X Liu et al.
Y Li et al.
Background: Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast cancer. Germline Pten mutatio...
Multiple redundant sequence elements within the fission yeast ura4 replication origin enhancer [0.03%]
裂殖酵母ura4复制起点增强子内的多个冗余序列元件
S M Kim,D Y Zhang,J A Huberman
S M Kim
Background: Some origins in eukaryotic chromosomes fire more frequently than others. In the fission yeast, Schizosaccharomyces pombe, the relative firing frequencies of the three origins clustered 4-8 kbp upstream of the ...
A simple method for generating full length cDNA from low abundance partial genomic clones [0.03%]
一种从低丰度部分基因组克隆生成全长cDNA的简便方法
Y Wang,J M Fugaro,F Siddiq et al.
Y Wang et al.
Background: PCR amplification of target molecules involves sequence specific primers that flank the region to be amplified. While this technique is generally routine, its applicability may not be sufficient to generate a ...
High affinity binding of proteins HMG1 and HMG2 to semicatenated DNA loops [0.03%]
蛋白质HMG1和HMG2与半联结DNA环的高亲和力结合
C Gaillard,F Strauss
C Gaillard
Background: Proteins HMG1 and HMG2 are two of the most abundant non histone proteins in the nucleus of mammalian cells, and contain a domain of homology with many proteins implicated in the control of development, such as...