Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C [0.03%]
SERINE/ARGININE-RICH splicing因子SRSF2的与骨髓增生异常综合征相关的突变导致CDC25C产生选择性剪切体
Lindsey Skrdlant,Jeremy M Stark,Ren-Jang Lin
Lindsey Skrdlant
Background: Serine-arginine rich splicing factor 2 (SRSF2) is a protein known for its role in RNA splicing and genome stability. It has been recently discovered that SRSF2, along with other splicing regulators, is frequen...
MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA [0.03%]
微小核糖核酸433通过靶向SMG5信使核糖核酸诱导无意义密码子介导的信使核糖核酸降解
Yi Jin,Fang Zhang,Zhenfa Ma et al.
Yi Jin et al.
Background: Nonsense-mediated mRNA decay (NMD) is a RNA quality surveillance system for eukaryotes. It prevents cells from generating deleterious truncated proteins by degrading abnormal mRNAs that harbor premature termin...
Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A [0.03%]
E.coli乳炎时，由于抑制性C/EBP因子表达增强和诱导物SREBP1A表达降低致使肝脏和乳腺中硬脂酰辅酶A去饱和酶1的表达下调
Tianle Xu,Xiangzhen Shen,Hans-Martin Seyfert
Tianle Xu
Background: Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism. Its synthesis is downregulated in liver during illnesses caused by high levels of circulatin...
Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein [0.03%]
双内皮素-1/血管内皮生长因子受体(DEspR)蛋白可译性及功能性的确认
Victoria L M Herrera,Martin Steffen,Ann Marie Moran et al.
Victoria L M Herrera et al.
Background: In contrast to rat and mouse databases, the NCBI gene database lists the human dual-endothelin1/VEGFsp receptor (DEspR, formerly Dear) as a unitary transcribed pseudogene due to a stop [TGA]-codon at codon#14 ...
Strong preference of BRCA1 protein to topologically constrained non-B DNA structures [0.03%]
BRCA1蛋白倾向于拓扑限制的非B DNA结构
Václav Brázda,Lucia Hároníková,Jack C C Liao et al.
Václav Brázda et al.
Background: The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repai...
Erratum to: Gene expression profiling of the venom gland from the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs) [0.03%]
图序修正：使用表达序列标签(ESTs)对委内瑞拉地图纳雷毒液腺基因进行表达图谱分析
Montamas Suntravat,Néstor L Uzcategui,Chairat Atphaisit et al.
Montamas Suntravat et al.
Published Erratum
BMC molecular biology. 2016 May 24;17(1):13. DOI:10.1186/s12867-016-0062-z 2016
A potential role for protein palmitoylation and zDHHC16 in DNA damage response [0.03%]
蛋白质棕榈酰化和zDHHC16在DNA损伤反应中的潜在作用
Na Cao,Jia-Kai Li,Yu-Qing Rao et al.
Na Cao et al.
Background: Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmi...
Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure [0.03%]
Pax8表达细胞中缺乏microRNAs的小鼠发生甲状腺功能减退和终末期肾衰竭
Malte P Bartram,Elena Amendola,Thomas Benzing et al.
Malte P Bartram et al.
Background: Non-coding RNAs have gained increasing attention during the last decade. The first large group of non-coding RNAs to be characterized systematically starting at the beginning of the 21st century were small oli...
Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer [0.03%]
信号转导及转录激活因子STAT5募集到c-MYC超级增强子上
Sophia Pinz,Samy Unser,Anne Rascle
Sophia Pinz
Background: c-Myc has been proposed as a putative target gene of signal transducer and activator of transcription 5 (STAT5). No functional STAT5 binding site has been identified so far within the c-Myc gene locus, therefo...
Immunoblot screening of CRISPR/Cas9-mediated gene knockouts without selection [0.03%]
无需筛选的CRISPR / Cas9介导的基因敲除的免疫印迹筛查技术
Jason A Estep,Erin L Sternburg,Gissell A Sanchez et al.
Jason A Estep et al.
Background: Targeted genomic editing using the CRISPR/Cas9 methodology has opened exciting new avenues in probing gene function in virtually any model system, including cultured mammalian cells. Depending on the desired m...