Tiantao Zhang,Yaqi Sun,Kevin W Wanner et al.
Tiantao Zhang et al.
Background: Pheromone binding proteins (PBPs) of male Lepidoptera function in chemical communication, mate attraction and recognition. Directional selection was previously predicted between PBP3 orthologs of Ostrinia furn...
Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants [0.03%]
植物中法尼基焦磷酸合成酶基因的正向选择与功能分化
Jieying Qian,Yong Liu,Naixia Chao et al.
Jieying Qian et al.
Background: Farnesyl pyrophosphate synthase (FPS) belongs to the short-chain prenyltransferase family, and it performs a conserved and essential role in the terpenoid biosynthesis pathway. However, its classification, evo...
Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5 [0.03%]
SOX5转录调控人源精子相关抗原16基因
Ling Zhang,Yunhao Liu,Wei Li et al.
Ling Zhang et al.
Background: The mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella for...
Heterogeneous pattern of DNA methylation in developmentally important genes correlates with its chromatin conformation [0.03%]
发育重要基因的DNA甲基化异质性模式与其染色质构象相关
Puja Sinha,Kiran Singh,Manisha Sachan
Puja Sinha
Background: DNA methylation is a major epigenetic modification, playing a crucial role in the development and differentiation of higher organisms. DNA methylation is also known to regulate transcription by gene repression...
Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes [0.03%]
关于人类单链DNA结合蛋白1（hSSB1）含蛋白质复合物组成的全新见解
Nicholas W Ashton,Dorothy Loo,Nicolas Paquet et al.
Nicholas W Ashton et al.
Background: Single-stranded DNA-binding proteins are essential cellular components required for the protection, metabolism and processing of single-stranded DNA. Human single-stranded DNA-binding protein 1 (hSSB1) is one ...
Meijun Du,Liang Wang
Meijun Du
Background: Chromosome conformation capture (3C) is a powerful and widely used technique for detecting the physical interactions between chromatin regions in vivo. The principle of 3C is to convert physical chromatin inte...
Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response [0.03%]
胸苷激酶1与p400解旋酶通过ATF1相互作用以提高DNA修复效率
Rebecca J Smith,Matthew S Savoian,Lauren E Weber et al.
Rebecca J Smith et al.
Background: Ataxia telangiectasia mutated (ATM) and TRRAP proteins belong to the phosphatidylinositol 3-kinase-related kinase family and are involved in DNA damage repair and chromatin remodeling. ATM is a checkpoint kina...
RNA polymerase II depletion promotes transcription of alternative mRNA species [0.03%]
RNA聚合酶II的耗竭促进了可变mRNA转录本的产生
Lijian Yu,Mayuri Rege,Craig L Peterson et al.
Lijian Yu et al.
Background: Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induct...
Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules [0.03%]
人类eIF4E同工酶亚型分别被募集到处理体和压力颗粒中
Klara Frydryskova,Tomas Masek,Katerina Borcin et al.
Klara Frydryskova et al.
Background: Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is r...
Joseph K Box,Nicolas Paquet,Mark N Adams et al.
Joseph K Box et al.
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular...