A fragment activity assay reveals the key residues of TBC1D15 GTPase-activating protein (GAP) in Chiloscyllium plagiosum [0.03%]
斑竹鲨TBC1D15 GAP蛋白活性位点的鉴定
Yangyang Jin,Guodong Lin,Yanna Chen et al.
Yangyang Jin et al.
Background: GTPase-activating proteins (GAPs) with a TBC (Tre-2/Bub2/Cdc16) domain architecture serve as negative regulators of Rab GTPases. The related crystal structure has been studied and reported by other members of ...
HexA is required for growth, aflatoxin biosynthesis and virulence in Aspergillus flavus [0.03%]
HexA是黄曲霉生长、黄曲霉素生物合成及致病力所必需的
Jun Yuan,Ding Li,Ling Qin et al.
Jun Yuan et al.
Background: Woronin bodies are fungal-specific organelles whose formation is derived from peroxisomes. The former are believed to be involved in the regulation of mycotoxins biosynthesis, but not in their damage repair fu...
Genome-wide identification of brain miRNAs in response to high-intensity intermittent swimming training in Rattus norvegicus by deep sequencing [0.03%]
高通量测序技术鉴定大鼠高强度间歇游泳训练响应的脑组织miRNA文库
Yanhong Zhao,Anmin Zhang,Yanfang Wang et al.
Yanhong Zhao et al.
Background: Physical exercise can improve brain function by altering brain gene expression. The expression mechanisms underlying the brain's response to exercise still remain unknown. miRNAs as vital regulators of gene ex...
MiRNAs differentially expressed in skeletal muscle of animals with divergent estimated breeding values for beef tenderness [0.03%]
肉质嫩度估计育种值分化明显的个体其骨骼肌中差异表达的miRNA们
Berna I G Kappeler,Luciana C A Regitano,Mirele D Poleti et al.
Berna I G Kappeler et al.
Background: MicroRNAs (miRNAs) are small noncoding RNAs of approximately 22 nucleotides, highly conserved among species, which modulate gene expression by cleaving messenger RNA target or inhibiting translation. MiRNAs ar...
Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma [0.03%]
氧化石墨烯通过下调胶质母细胞瘤中氧化磷酸化复合物的基因表达发挥抗肿瘤作用
Maciej Szmidt,Adrian Stankiewicz,Kaja Urbańska et al.
Maciej Szmidt et al.
Background: Recently different forms of nanographene were proposed as the material with high anticancer potential. However, the mechanism of the suppressive activity of the graphene on cancer development remains unclear. ...
The Dictyostelium discoideum homologue of Twinkle, Twm1, is a mitochondrial DNA helicase, an active primase and promotes mitochondrial DNA replication [0.03%]
双星草履虫Twinkle同源物Twm1是线粒体DNA解旋酶，活性引物酶，并促进线粒体DNA复制
Ashley Harman,Christian Barth
Ashley Harman
Background: DNA replication requires contributions from various proteins, such as DNA helicases; in mitochondria Twinkle is important for maintaining and replicating mitochondrial DNA. Twinkle helicases are predicted to a...
Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis [0.03%]
矩阵区/支架附着区（MAR/SAR）序列通过氧化应激诱导的细胞凋亡介导鼻咽上皮细胞染色体断裂的潜在作用研究
Sang-Nee Tan,Sai-Peng Sim,Alan S B Khoo
Sang-Nee Tan
Background: Oxidative stress is known to be involved in most of the aetiological factors of nasopharyngeal carcinoma (NPC). Cells that are under oxidative stress may undergo apoptosis. We have previously demonstrated that...
Leiah M Luoma,Fred B Berry
Leiah M Luoma
Background: NPAS3 encodes a transcription factor which has been associated with multiple human psychiatric and neurodevelopmental disorders. In mice, deletion of Npas3 was found to cause alterations in neurodevelopment, a...
Integration of transcriptome and proteome profiles in glioblastoma: looking for the missing link [0.03%]
整合胶质母细胞瘤转录组和蛋白质组谱型：寻找缺失的环节
Jean-Michel Lemée,Anne Clavreul,Marc Aubry et al.
Jean-Michel Lemée et al.
Background: Glioblastoma (GB) is the most common and aggressive tumor of the brain. Genotype-based approaches and independent analyses of the transcriptome or the proteome have led to progress in understanding the underly...
Analyses of changes in myocardial long non-coding RNA and mRNA profiles after severe hemorrhagic shock and resuscitation via RNA sequencing in a rat model [0.03%]
大鼠严重失血性休克复苏后心肌长链非编码RNA和信使RNA谱型变化的RNA测序分析
Lin Lin,Zhengfei Yang,Guanghui Zheng et al.
Lin Lin et al.
Background: Ischemia-reperfusion injury has been proven to induce organ dysfunction and death, although the mechanism is not fully understood. Long non-coding RNAs (lncRNAs) have drawn wide attention with their important ...