Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells [0.03%]
基于mRNA谱分析解码前列腺癌细胞中新的Esrrb应答基因
Yuan Lu,Jilong Li,Jianlin Cheng et al.
Yuan Lu et al.
Background: Orphan nuclear receptor estrogen related receptor β (Esrrb or ERRβ) is well known in stem cells and early embryonic development. However, little is known about its function in cancer. ...
Temperature-induced variation in gene expression burst size in metazoan cells [0.03%]
模式动物细胞中温度变化诱导基因表达爆发大小的变异
Ophélie Arnaud,Sam Meyer,Elodie Vallin et al.
Ophélie Arnaud et al.
Background: Gene expression is an inherently stochastic process, owing to its dynamic molecular nature. Protein amount distributions, which can be acquired by cytometry using a reporter gene, can inform about the mechanis...
Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor β [0.03%]
Hedgehog信号通路靶基因可受雌激素相关受体β的调节
Yuan Lu,Jilong Li,Jianlin Cheng et al.
Yuan Lu et al.
Background: Nuclear receptor family member, Estrogen related receptor β, and the Hedgehog signal transduction pathway are both reported to relate to tumorigenesis and induced pluripotent stem cell reprogramming. We hypot...
DNA double-strand break repair is impaired in presenescent Syrian hamster fibroblasts [0.03%]
叙利亚地鼠早衰细胞的DNA双链断裂修复功能受损
Ljudmila Solovjeva,Denis Firsanov,Anastasia Vasilishina et al.
Ljudmila Solovjeva et al.
Background: Studies of DNA damage response are critical for the comprehensive understanding of age-related changes in cells, tissues and organisms. Syrian hamster cells halt proliferation and become presenescent after sev...
The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner [0.03%]
延伸因子eEF3(Yef3)以非依赖翻译的方式与mRNA相互作用
Nitzan Samra,Avigail Atir-Lande,Lilach Pnueli et al.
Nitzan Samra et al.
Background: mRNA binding proteins (RBPs) constitute 10-15% of the eukaryotic proteome and play important part in post-transcriptional regulation of gene expression. Due to the instability of RNA and the transient nature i...
Deciphering targeting rules of splicing modulator compounds: case of TG003 [0.03%]
揭示剪接调节化合物作用机制的规则——TG003靶点剖析案例分析
Maki Sakuma,Kei Iida,Masatoshi Hagiwara
Maki Sakuma
Background: Recent advances in the development of small chemical compounds that can modulate RNA splicing brought excitement to the field of splicing-targeting therapy. Splicing-targeting therapy tries to ameliorate the d...
RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription [0.03%]
RE1沉默转录因子(REST)通过抑制染色体1q衍生的基因(AF1q)转录发挥负调控作用
Yuanyuan Hu,Qianwen Sun,Chen Zhang et al.
Yuanyuan Hu et al.
Background: ALL1-fused from chromosome 1q (AF1q), originally considered as an oncogenic factor, has been implicated in neuronal development; however, its upstream regulatory mechanisms in neural system remained elusive. ...
Heeyoun Bunch,Stuart K Calderwood
Heeyoun Bunch
TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation. TRIM28 was shown to stabilize the pausing of RNA polym...
Rasmus Wernersson,Thomas Frogne,Claude Rescan et al.
Rasmus Wernersson et al.
Background: In gene expression analysis, overlapping genes, splice variants, and fusion transcripts are potential sources of data analysis artefacts, depending on how the observed intensity is assigned to one, or more gen...
SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp [0.03%]
SIRT6蛋白去乙酰化酶与MYH DNA糖基化酶、APE1内切酶和Rad9-Rad1-Hus1检查点夹子相互作用
Bor-Jang Hwang,Jin Jin,Ying Gao et al.
Bor-Jang Hwang et al.
Background: SIRT6, a member of the NAD(+)-dependent histone/protein deacetylase family, regulates genomic stability, metabolism, and lifespan. MYH glycosylase and APE1 are two base excision repair (BER) enzymes involved i...