Genomics as a time capsule: insights from Oreobates chiquitanus type specimens [0.03%]
基因组作为时间胶囊：Oreobates chiquitanus 模式标本的见解
Yannis Schöneberg,Marcel Nebenführ,Martin Jansen et al.
Yannis Schöneberg et al.
Background: Biodiversity is at increasing risk, and amphibians are the most threatened vertebrate class, with 40.7% of species globally at risk. For amphibians, the primary cause for their decline is habitat loss. The sca...
A circRNA-miRNA-mRNA network potentially regulates skeletal muscle adaptation to hypoxia in Tibetan sheep [0.03%]
藏羊骨骼肌适应缺氧的circRNA-miRNA-mRNA网络研究
Pengfei Zhao,Yaqin Zhang,Jing Ma et al.
Pengfei Zhao et al.
Background: The extreme environmental conditions of high-altitude regions, particularly hypoxia, pose significant challenges to animal survival. Tibetan sheep serve as an exemplary model for studying mammalian hypoxic ada...
Evaluating the learnability of single-cell large language models on multiple tasks [0.03%]
评估单细胞大型语言模型在多项任务上的学习能力
Yu Yan,Xutao Wang,Dongyuan Song
Yu Yan
The rise of single-cell foundation models (scFMs) has sparked interest in their potential to unify diverse biological tasks. However, their practical utility and the validity of scaling laws-the assumption that performance improves with mod...
Genome-wide analysis of the NLR gene family in strawberry reveals a novel immune receptor architecture in Rosaceae [0.03%]
全基因组草莓NLR基因家族分析揭示了蔷薇科特有的免疫受体结构
Alicia Sillers,Mishi V Vachev,Marta Bjornson et al.
Alicia Sillers et al.
Background: Nucleotide-binding leucine-rich-repeat receptors (NLRs) are key components of plant innate immunity. These intracellular proteins specifically recognize pathogen effectors and subsequently activate a defense r...
Comparative genomics and epidemic success of Mycobacterium tuberculosis lineage 4 in eastern China [0.03%]
中国东部结核病菌株4的基因组和疫区优势
Zong-Lei Zhou,Qi Wu,Zheng-Wei Liu et al.
Zong-Lei Zhou et al.
Background: Mycobacterium tuberculosis (Mtb) lineage 4 (L4) remains as a crucial component of the pathogen. Genetic factors potentiate the spread of Mtb, while the genomic feature and epidemic success at individual level ...
Comparative genomic and functional insights into life-cycle plasticity and host adaptation in a wild Nippostrongylus brasiliensis strain from Guangzhou [0.03%]
广州广州巴西弓首线虫野外株系的全基因组分析及其宿主适应性研究
Xi Pan,Jinzhi Lu,Chuyue Wang et al.
Xi Pan et al.
Background: Nippostrongylus brasiliensis (rat hookworm) is a key model for studying human hookworm infection. Results: A wild N. brasil...
Chromosome-level genome assembly of Trichiurus japonicus resolves species boundaries and evolutionary history of cutlassfishes in Northwest Pacific [0.03%]
日本刀鱼染色体水平基因组组装解析西北太平洋刀鱼属物种界限及进化历史
Vanthu Giap,Tianqin Wu,Liang Lu et al.
Vanthu Giap et al.
Persistent taxonomic uncertainty has plagued the Trichiuridae family (hairtails), a group of ecologically and commercially significant fishes, a result of conflicting morphological criteria and historical misclassifications. While molecular...
Strategies for integrating whole-genome sequencing into antimicrobial resistance surveillance [0.03%]
基于全基因组测序的抗菌药物耐药性监测策略分析
Younggwon On,Eun-Jeong Yoon
Younggwon On
Background: Antimicrobial resistance (AMR) poses a significant global public health challenge requiring improved diagnostic procedures and strategic surveillance. Such surveillance is imperative for monitoring resistance ...
Reassessing Murinae phylogeny: integrated mitogenomic and codon usage evidence challenges the sister relationship of Micromyini and Vernayini [0.03%]
重新评估鼠亚科的系统发育关系：整合线粒体基因组和密码子使用证据挑战Micromyini和Vernayini姐妹群关系
Zhongsong Wang,Di Zhao,Wenyu Song et al.
Zhongsong Wang et al.
Background: The Murinae subfamily, one of the most diverse and widely distributed rodent groups, is an important model in ecology, evolutionary biology, and biomedical research. However, deep-level phylogenetic relationsh...
Tracing the evolutionary genomics of blaNDM-harboring Salmonella typhimurium in China [0.03%]
中国产超广谱blaNDM携带者 Salmonella typhimurium 的进化基因组学研究
Jianbo Ye,Yali Zheng,Dakang Hu et al.
Jianbo Ye et al.
Background: Carbapenem-resistant Salmonella Typhimurium (S. Typhimurium) is occasionally reported, primarily driven by the dissemination of the blaNDM gene. Although this poses an emerging threat, its phylogenetic structu...