Mdwgan-gp: data augmentation for gene expression data based on multiple discriminator WGAN-GP [0.03%]
基于多判别器WGAN-GP的基因表达数据增强方法(MDWGAN-GP)
Rongyuan Li,Jingli Wu,Gaoshi Li et al.
Rongyuan Li et al.
Background: Although gene expression data play significant roles in biological and medical studies, their applications are hampered due to the difficulty and high expenses of gathering them through biological experiments....
DG-Affinity: predicting antigen-antibody affinity with language models from sequences [0.03%]
基于序列的语言模型预测抗原抗体亲和力
Ye Yuan,Qushuo Chen,Jun Mao et al.
Ye Yuan et al.
Background: Antibody-mediated immune responses play a crucial role in the immune defense of human body. The evolution of bioengineering has led the progress of antibody-derived drugs, showing promising efficacy in cancer ...
Xin Feng,Yihuai Cai,Ruihao Xin
Xin Feng
Background: Diabetes is a metabolic disorder usually caused by insufficient secretion of insulin from the pancreas or insensitivity of cells to insulin, resulting in long-term elevated blood sugar levels in patients. Pati...
Statistical modeling to quantify the uncertainty of FoldX-predicted protein folding and binding stability [0.03%]
统计建模量化FoldX预测的蛋白质折叠和结合稳定性的不确定性
Yesol Sapozhnikov,Jagdish Suresh Patel,F Marty Ytreberg et al.
Yesol Sapozhnikov et al.
Background: Computational methods of predicting protein stability changes upon missense mutations are invaluable tools in high-throughput studies involving a large number of protein variants. However, they are limited by ...
Irena Roterman,Katarzyna Stapor,Leszek Konieczny
Irena Roterman
Background: Recently, significant progress has been made in the field of protein structure prediction by the application of artificial intelligence techniques, as shown by the results of the CASP13 and CASP14 (Critical As...
ILIAD: a suite of automated Snakemake workflows for processing genomic data for downstream applications [0.03%]
iliad：一个用于处理基因组数据的自动化Snakemake工作流工具套件用于后续应用
Noah Herrick,Susan Walsh
Noah Herrick
Background: Processing raw genomic data for downstream applications such as imputation, association studies, and modeling requires numerous third-party bioinformatics software tools. It is highly time-consuming and resour...
A model-based clustering via mixture of hierarchical models with covariate adjustment for detecting differentially expressed genes from paired design [0.03%]
一种基于模型的聚类方法通过分层混合模型和协变量调整以从配对设计中识别差异表达基因
Yixin Zhang,Wei Liu,Weiliang Qiu
Yixin Zhang
The causes of many complex human diseases are still largely unknown. Genetics plays an important role in uncovering the molecular mechanisms of complex human diseases. A key step to characterize the genetics of a complex human disease is to...
Comparative Study of Single-stranded Oligonucleotides Secondary Structure Prediction Tools [0.03%]
单链寡核苷酸二级结构预测工具的比较研究
Thomas Binet,Séverine Padiolleau-Lefèvre,Stéphane Octave et al.
Thomas Binet et al.
Background: Single-stranded nucleic acids (ssNAs) have important biological roles and a high biotechnological potential linked to their ability to bind to numerous molecular targets. This depends on the different spatial ...
Fast alignment of mass spectra in large proteomics datasets, capturing dissimilarities arising from multiple complex modifications of peptides [0.03%]
大型蛋白质组数据集中的快速质谱对齐，捕获源自肽多个复杂修饰的差异性
Grégoire Prunier,Mehdi Cherkaoui,Albane Lysiak et al.
Grégoire Prunier et al.
Background: In proteomics, the interpretation of mass spectra representing peptides carrying multiple complex modifications remains challenging, as it is difficult to strike a balance between reasonable execution time, a ...
Sctensor detects many-to-many cell-cell interactions from single cell RNA-sequencing data [0.03%]
基于单细胞RNA测序数据检测多对多的细胞间相互作用
Koki Tsuyuzaki,Manabu Ishii,Itoshi Nikaido
Koki Tsuyuzaki
Background: Complex biological systems are described as a multitude of cell-cell interactions (CCIs). Recent single-cell RNA-sequencing studies focus on CCIs based on ligand-receptor (L-R) gene co-expression but the analy...