VEGF inhibitor-induced vascular dysfunction involves redox-sensitive PARP activation and SIRT1 disruption [0.03%]
vegf抑制剂诱导的血管功能障碍涉及红氧化敏感性parp激活和紊乱失调
Karla B Neves,Rheure Alves-Lopes,Augusto C Montezano et al.
Karla B Neves et al.
Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecu...
Timing-dependent protective and therapeutic effects of ethyl pyruvate in trinitrobenzene sulfonic acid-induced experimental colitis [0.03%]
乙酰基丙酸的保护和治疗作用依赖于实验性结肠炎的诱导后的时间点
Hatice Yorulmaz,Elif Yorulmaz,Elif Özkök et al.
Hatice Yorulmaz et al.
Ulcerative colitis (UC) involves excessive inflammation, extracellular matrix remodelling and oxidative stress. Ethyl pyruvate (EP) exhibits anti-inflammatory effects, but the comparative efficacy of prophylactic versus therapeutic administ...
(Dis)agreement and concordance of metabolic indices from the oral glucose tolerance test and mixed-meal tolerance test: Implications for application [0.03%]
口服葡萄糖耐量试验和混合餐耐量试验的代谢指标的不一致与一致性：对应用的影响
Nina Sloth Nielsen,Nikolaj Agerlin,Nikolas Antoniou et al.
Nina Sloth Nielsen et al.
Metabolic indices derived from the oral glucose tolerance test (OGTT) and mixed-meal tolerance test (MMTT) are often interpreted interchangeably; however, these tests represent distinct physiological stimuli. In order to examine potential d...
Jumping in simulated lunar gravity with blood flow restriction as a potential exercise countermeasure: The acute physiological effects [0.03%]
穿着束缚装置进行模拟月球重力跳跃对生理急性影响的初步研究
Patrick Swain,Filipa Santos,Nick Caplan et al.
Patrick Swain et al.
The present study examined the cardiovascular, metabolic, neuromuscular and perceptual effects of low-intensity jumping in simulated lunar gravity (∼20% bodyweight) with blood flow restriction (BFR). Fourteen healthy adults (24 ± 4 years;...
Katherine Hill,Lyndal Roper
Katherine Hill
Editorial
Experimental physiology. 2026 Jun 17. DOI:10.1113/EP093919 2026
Phosphate and acidosis cause fibre-typespecific changes to cellular and molecular contractile mechanics at 37°C in skeletal muscle from older adults [0.03%]
磷酸盐和酸中毒引起老年人大肌肉在37℃下纤维类型特异性收缩机械特性变化
Brent A Momb,Jane A Kent,Stuart R Chipkin et al.
Brent A Momb et al.
Intracellular accumulation of hydrogen ions (H+) and inorganic phosphate (Pi) has temperature-dependent effects on single-fibre contractile function between 10°C and 30°C. In vivo, human skeletal muscle temperatures range between 35-39°C...
Effects of tumour necrosis factor and interleukin-6 inhibitor therapy on exercise-related visceral adipose tissue reduction in rheumatoid arthritis [0.03%]
肿瘤坏死因子和白细胞介素-6抑制治疗对类风湿关节炎患者运动减脂的影响研究
Simon Jønck,Malte Lund Adamsen,Iben E Rasmussen et al.
Simon Jønck et al.
Excess visceral adipose tissue (VAT) mass increases cardiovascular disease risk. Exercise supports overall health and VAT mass reduction in rheumatoid arthritis (RA). Unlike tumour necrosis factor (TNF), interleukin-6 (IL-6) is upregulated ...
Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study [0.03%]
热疗结合混合锻炼康复训练可减轻雄性小鼠悬垂后下肢蛋白周转的细胞标志物：一项试点研究
Tom Normand-Gravier,Robert Solsona,Christelle Bertrand-Gaday et al.
Tom Normand-Gravier et al.
Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both endura...
Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise [0.03%]
血管限制运动的神经生理反应和机制的转化视角
Kai T Fox,Luke Hughes,Brendan R Scott et al.
Kai T Fox et al.
Maintaining corticospinal tract function is crucial for voluntary movement. Exercise using high external loads/intensities is a promising intervention to promote adaptations to the corticospinal tract and improve physical function; however,...
Independent and synergistic effects of maternal and paternal obesogenic diets on offspring early-life outcomes in the rat [0.03%]
独立的和协同的肥胖饮食对子代早期生活结局的作用：大鼠实验研究
Khurram Jahangir Toor,Mehwish Abbasi,Swetha Muralidharan et al.
Khurram Jahangir Toor et al.
Independent effects of maternal obesogenic diets on offspring outcomes are acknowledged, but data on paternal and combined maternal-paternal obesity remain limited. We investigated independent and combined maternal-paternal effects of an ob...