Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation [0.03%]
不同重力级别下失血对中枢血液循环和心血管自主调节的剂量依赖性影响
Adrien Robin,Cort D Reinarz,Huc Pentinat-Llurba et al.
Adrien Robin et al.
The cardiovascular system is strongly influenced by gravitational loading and blood volume status. Quantifying central haemodynamic and autonomic reflex responses to fluid redistribution is important in altered-gravity conditions, with rele...
Interindividual variability in static apnoea performance is partly explained by genetic factors [0.03%]
静息性呼吸暂停的个体差异部分由遗传因素决定
Anastasios Makris,Alexandros Sotiridis,Nickos Geladas et al.
Anastasios Makris et al.
A large interindividual variability exists in maximal apnoea duration and the physiological adjustments that occur during apnoea. Although a few genes have been found to be associated with some of the cardiovascular responses during apnoea,...
Substrate-specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts [0.03%]
2型糖尿病大鼠心脏线粒体功能障碍及代谢组学特征的底物特异性研究
Toan Pham
Toan Pham
Type 2 diabetes (T2D) greatly alters cardiac fuel handling, yet how mitochondrial function adapts to the diabetic substrate environment remains unclear. This study investigated substrate-specific cardiac mitochondrial bioenergetics from a T...
Robin Christensen,Tobias Haugegaard,Janus C Jakobsen
Robin Christensen
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model [0.03%]
线粒体肽MOTS-c通过抑制炎症小体活化来改善糖尿病大鼠心脏功能损伤
Aimee R Mills,Antonio de Souza,Toan Pham et al.
Aimee R Mills et al.
Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy. The mitochondrial-derived peptide mitochondrial open reading frame of the 12S rRNA typ...
Digital N-of-1 trials and their application in experimental physiology [0.03%]
数字N-of-1试验及其在实验生理学中的应用
Stefan Konigorski,Mathias Ried-Larsen,Christopher H Schmid
Stefan Konigorski
Traditionally, studies in experimental physiology have been conducted in small groups of human participants, animal models or cell lines. Identifying optimal study designs that achieve sufficient power for drawing proper statistical inferen...
Gabriela Arenas,Andrea Morales,Andrea Leiva et al.
Gabriela Arenas et al.
Human breast milk (BM) is an essential fluid for infant development, with a dynamic composition adapted to the infant's needs. It contains bioactive lipids like cholesterol, typically transported by lactosomes, extracellular vesicles, and m...
Effects of 14 days of head-down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults [0.03%]
头下卧床14天（含或不含运动）以及之后的恢复对人体老年人骨转换、密度和结构的影响
Guy Hajj-Boutros,Andréa Faust,Carmelo Mastrandrea et al.
Guy Hajj-Boutros et al.
Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head-down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure in...
Stroke neurovascular responses to exercise: A novel rehabilitation paradigm [0.03%]
运动性脑血管反应在卒中康复中的应用：一种新型的康复模式
Alicen A Whitaker-Hilbig,Allison S Hyngstrom,Matthew J Durand
Alicen A Whitaker-Hilbig
Stroke is a leading cause of long-term disability, impacting the cerebrovascular, peripheral vascular and neuromotor systems. Characterising vascular responses to exercise post-stroke offers valuable insights into the impairments that might...
The impact of statistical choice on variability and error in maximal respiratory mouth pressure testing [0.03%]
统计选择对最大呼气嘴压力测试变异性和误差的影响
Mitch Lomax,Josh Osofa,Nicola Armstrong et al.
Mitch Lomax et al.
Various statistics have been used to assess repeatability and reproducibility of maximal inspiratory and expiratory mouth pressure measurements (PImax and PEmax, respectively). Few studies have examined the impact of rater experience on the...