Ageing alters cysteine oxidation-regulated redox signalling in skeletal muscle: Integrative omics and AI-based structural predictions [0.03%]
衰老改变了骨骼肌半胱氨酸氧化调节的红氧信号通路：整合组学和基于人工智能的结构预测
Ufuk Ersoy,Malcolm J Jackson
Ufuk Ersoy
Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine-based regulation are...
Alterations to longitudinal muscle morphology and mechanical function following immobilization and recovery in female ovariectomized and intact rats [0.03%]
绝经后和完整大鼠固定后的纵向肌肉形态和机械功能的变化及恢复情况研究
Alexandra Q Kirkup,Amelia Rilling,Alexander M Zero et al.
Alexandra Q Kirkup et al.
Serial sarcomere number (SSN) is reduced following immobilization of a muscle in a shortened position in male rodents thereby impairing muscle contractile function. However, in female rodents the effects of oestrogen on SSN and mechanical c...
Physiological evaluation of the Calgary adapted aRm ergometer (CARE) concussion exertion test in adolescent athletes: A repeated-measures observational study [0.03%]
卡尔加里改良上肢运动试验(CARE)在青少年运动员中评估脑震荡损伤的生理效应：一项自身重复测量观察性研究
Joshua J Burkart,Matthew G Neill,Jean-Michel Galarneau et al.
Joshua J Burkart et al.
Exertion testing helps inform exercise prescription during concussion recovery. The Calgary Adapted aRm Ergometer (CARE) test, developed as the first upper-body specific exertion test, aims to improve accessibility and inclusivity in concus...
The acute effects of exercise intensity and inorganic nitrate supplementation on the Buckberg ratio in postmenopausal females [0.03%]
运动强度和无机硝酸盐补充对绝经后女性布克伯格比值的急性影响
Cassandra C Derella,Austin C Hogwood,Joaquin Ortiz de Zevallos et al.
Cassandra C Derella et al.
Menopause increases coronary heart disease risk, in part through reduced oestrogen-mediated nitric oxide (NO) bioavailability. The Buckberg ratio, an index of myocardial oxygen supply-demand balance, in which higher values reflect more favo...
From hot tub to high altitude: The makings of a human physiology field expedition and the next generation of physiologists [0.03%]
从泡温泉到高海拔：人类生理学野外考察的形成和下一代生理学家的成长之路
M M Tymko,K J Smith,A R Bain et al.
M M Tymko et al.
Editorial
Experimental physiology. 2026 Jul 6. DOI:10.1113/EP094074 2026
Dendritic cell-specific hypoxia-inducible factor-1α deficiency protects mice from recurrent retroviral infection [0.03%]
缺氧诱导因子-1α缺乏的树突状细胞使小鼠免遭逆转录病毒感染反复侵袭
Timm Schreiber,Yvonne Hüsecken,Claudia Lodewick et al.
Timm Schreiber et al.
Antigen-processing and -presenting cells play a pivotal role in initiation of the antiviral immune response. The cellular adaption of dendritic cells to reduced oxygen and nutrition levels at the site of infection is regulated predominantly...
Very low-amplitude muscle activity increases probability of motor evoked potentials in healthy individuals and in amyotrophic lateral sclerosis [0.03%]
极低频肌肉活动增加健康人和肌萎缩侧索硬化患者的运动诱发电位概率
Séamus O&#x;Sullivan,Yasmine Tadjine,Gabriel R Palma et al.
Séamus O&#x;Sullivan et al.
Muscle contraction increases motor evoked potential (MEP) amplitude, decreasing motor threshold (MT). Correspondingly, trials where baseline EMG amplitude exceeds a specified threshold are often rejected. We aimed to investigate the influen...
Long-term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats [0.03%]
通过哺乳期摄入可可壳提取物对胎儿期营养不良和对照大鼠长期心血管不良变化的影响
Santiago Ruvira,Pilar Rodríguez-Rodríguez,Metee Iampanichakul et al.
Santiago Ruvira et al.
Cocoa shell extract (CSE; rich in antioxidant compounds) administered to adult hypertensive rats exposed to fetal undernutrition (MUN) reduces blood pressure, improving cardiovascular alterations. We aimed to explore lactation as a reprogra...
Divergent skeletal muscle metabolite exchange in insulin-like growth factor-1-stimulated myotubes and resistance-exercised human muscle [0.03%]
胰岛素样生长因子-1刺激的肌管和阻力锻炼的人肌肉中骨骼肌代谢物交换的分歧
Tim Havers,Moritz Eggelbusch,Marius Meinhold et al.
Tim Havers et al.
Skeletal muscle hypertrophy requires a substantial nutrient influx for biomass accretion, but global metabolite exchange during growth is poorly characterized. Therefore, we profiled the metabolite uptake and release in insulin-like growth ...