Intermittent low-intensity contractions cause a dissociation between maximal motor unit firing rates and changes in torque and contractile speed [0.03%]
间歇性低强度收缩可使最大运动神经元放电频率与扭矩和收缩速度的改变相分离
Alexander M Zero,Raaj A Dudani,Jacob Fanous et al.
Alexander M Zero et al.
The purpose was to test: (1) whether the decline in maximal motor unit (MU) firing rate is an invariable response when maximal voluntary contraction (MVC) torque is reduced following a submaximal muscle fatiguing task; and (2) whether fatig...
Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes [0.03%]
烟碱受体信号通路调控代谢综合征心肌细胞内的钙稳态及线粒体功能
Firat Akat,Leila Aryan,Suatnur Şık et al.
Firat Akat et al.
Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these al...
The physiology of survival: From the third man to placebo escape hatch? [0.03%]
生存的生理学：从第三男人到安慰剂逃生舱？
Frank E Marino,Alexander F Marino
Frank E Marino
Elliott J Jenkins,Joseph A Killick,Sally R Grimm et al.
Elliott J Jenkins et al.
Far-infrared (FIR) saunas are increasingly used as a passive heating and 'wellness' modality, yet their capacity to elevate core temperature remains unclear, particularly given prior work at lower temperatures (∼45°C) reports limited net ...
Systemic pirfenidone treatment fails to mitigate fibrosis and compromises functional recovery in a porcine model of volumetric muscle loss [0.03%]
系统性吡非尼酮治疗未能缓解体积肌肉损失猪模型中的纤维化并影响功能恢复
Jessica M Motherwell,Ondine Eken,Claudia E Hernandez et al.
Jessica M Motherwell et al.
Repurposing clinically approved antifibrotic agents presents a potential near-term therapeutic strategy to mitigate the extensive fibrotic scarring that follows severe volumetric muscle loss (VML) injury and inhibits functional recovery. We...
Macro- and microcirculatory factors affecting foot temperature change during walking [0.03%]
步行时影响足部温度变化的宏观和微观循环因素
Jose G Anguiano-Hernandez,Jenna K Burnett,Michael F Allen et al.
Jose G Anguiano-Hernandez et al.
Change in skin temperature is a complex process affected by several factors. During walking, increased microcirculatory activity, such as muscle metabolism, could increase foot temperature. The ensuing macrocirculatory responses, such as in...
Haemodynamic responses to head-up tilt versus lower-body negative pressure in type 1 diabetes [0.03%]
1型糖尿病患者仰卧倾斜与下肢负压对血液动力学的影响
Victorien Faivre-Rampant,Jules Warnier,Perrine Larmet et al.
Victorien Faivre-Rampant et al.
Head-up tilt (HUT) and lower-body negative pressure (LBNP) both reduce central blood volume but differ in heart orientation and regional fluid shifts. Whether they evoke comparable cardiovascular regulation when matched for preload remains ...
Traumatic arteriovenous fistula after ice axe injury 27 years ago: A case report [0.03%]
27年前冰镐伤所致创伤性动静脉瘘1例报告
Kate N Thomas,Emma M W Jones,Arunesh Majumder et al.
Kate N Thomas et al.
We report a case of a traumatic arteriovenous fistula (AVF) between the superficial femoral artery and femoral vein that went undetected for 27 years following an ice axe injury during a climbing accident in 1997. An AVF is an abnormal conn...
Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy [0.03%]
抑制肌肉生长：肌生长抑制素调节失用性萎缩的作用
Derk H C Nieuwenhuijsen,Moritz Eggelbusch,Rob C I Wüst
Derk H C Nieuwenhuijsen
Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass ...
Acute exercise-induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice [0.03%]
肥胖和衰老小鼠的急性运动诱导的脂解和脂肪组织中羟基脂肪酸酯水平的增加受损
Marko Mitrovic,Olga Horakova,Martin Riecan et al.
Marko Mitrovic et al.
Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of spe...