Feature selection in finite mixture of sparse normal linear models in high-dimensional feature space [0.03%]
高维特征空间下的有限混合稀疏高斯线性模型的特征选择方法研究
Abbas Khalili,Jiahua Chen,Shili Lin
Abbas Khalili
Rapid advancement in modern technology has allowed scientists to collect data of unprecedented size and complexity. This is particularly the case in genomics applications. One type of statistical problem in such applications is concerned wi...
Lu Tian,Robert Tibshirani
Lu Tian
We use the term "index predictor" to denote a score that consists of K binary rules such as "age > 60" or "blood pressure > 120 mm Hg." The index predictor is the sum of these binary scores, yielding a value from 0 to K. Such indices as oft...
Treatment-effect estimates adjusted for small-study effects via a limit meta-analysis [0.03%]
通过限值meta分析校正小样本影响的处理效果估计值
Gerta Rücker,Guido Schwarzer,James R Carpenter et al.
Gerta Rücker et al.
Statistical heterogeneity and small-study effects are 2 major issues affecting the validity of meta-analysis. In this article, we introduce the concept of a limit meta-analysis, which leads to shrunken, empirical Bayes estimates of study ef...
Wen Gu,Margaret Sullivan Pepe
Wen Gu
The diagnostic likelihood ratio function, DLR, is a statistical measure used to evaluate risk prediction markers. The goal of this paper is to develop new methods to estimate the DLR function. Furthermore, we show how risk prediction marker...
Comparative Study
Biostatistics (Oxford, England). 2011 Jan;12(1):87-101. DOI:10.1093/biostatistics/kxq045 2011
A multilevel model to address batch effects in copy number estimation using SNP arrays [0.03%]
一种多水平模型 用于利用SNP微阵列估算拷贝数以解决批次效应问题
Robert B Scharpf,Ingo Ruczinski,Benilton Carvalho et al.
Robert B Scharpf et al.
Submicroscopic changes in chromosomal DNA copy number dosage are common and have been implicated in many heritable diseases and cancers. Recent high-throughput technologies have a resolution that permits the detection of segmental changes i...
Two-dimensional toxic dose and multivariate logistic regression, with application to decompression sickness [0.03%]
二维毒性剂量与多元逻辑回归及其在减压病中的应用研究
Jialiang Li,Weng Kee Wong
Jialiang Li
In toxicological experiments with laboratory animals, there are usually many response variables of interest. When the response variables are continuous, parametric or nonparametric multivariate analysis of variance techniques can be applied...
Holger Schwender,Ingo Ruczinski,Katja Ickstadt
Holger Schwender
A major goal of genetic association studies concerned with single nucleotide polymorphisms (SNPs) is the detection of SNPs exhibiting an impact on the risk of developing a disease. Typically, this problem is approached by testing each of th...
Comparative Study
Biostatistics (Oxford, England). 2011 Jan;12(1):18-32. DOI:10.1093/biostatistics/kxq042 2011
Vernon T Farewell,Li Su
Vernon T Farewell
Time-to-event and similar analyses can be problematic if the event of interest is operationally defined by some condition being true for a prolonged period of time. A particular example of this, remission in psoriatic arthritis, is consider...
Comparative Study
Biostatistics (Oxford, England). 2011 Jan;12(1):102-11. DOI:10.1093/biostatistics/kxq041 2011
Multiple testing on standardized mortality ratios: a Bayesian hierarchical model for FDR estimation [0.03%]
基于Bayesian分层模型的标准化死亡率比的FDR估计方法研究
Massimo Ventrucci,E Marian Scott,Daniela Cocchi
Massimo Ventrucci
The analysis of large data sets of standardized mortality ratios (SMRs), obtained by collecting observed and expected disease counts in a map of contiguous regions, is a first step in descriptive epidemiology to detect potential environment...
Methods for testing association between uncertain genotypes and quantitative traits [0.03%]
处理不确定基因型的定量性状定位方法研究
Zoltán Kutalik,Toby Johnson,Murielle Bochud et al.
Zoltán Kutalik et al.
Interpretability and power of genome-wide association studies can be increased by imputing unobserved genotypes, using a reference panel of individuals genotyped at higher marker density. For many markers, genotypes cannot be imputed with c...
Comparative Study
Biostatistics (Oxford, England). 2011 Jan;12(1):1-17. DOI:10.1093/biostatistics/kxq039 2011