Szymon Urbas,Chris Sherlock,Paul Metcalfe
Szymon Urbas
We introduce a general framework for monitoring, modeling, and predicting the recruitment to multi-center clinical trials. The work is motivated by overly optimistic and narrow prediction intervals produced by existing time-homogeneous recr...
The role of body mass index at diagnosis of colorectal cancer on Black-White disparities in survival: a density regression mediation approach [0.03%]
诊断结肠直肠癌时体质指数在黑人和白人生存率差异中的作用：密度回归中介方法
Katrina L Devick,Linda Valeri,Jarvis Chen et al.
Katrina L Devick et al.
The study of racial/ethnic inequalities in health is important to reduce the uneven burden of disease. In the case of colorectal cancer (CRC), disparities in survival among non-Hispanic Whites and Blacks are well documented, and mechanisms ...
Immune correlates analysis using vaccinees from test negative designs [0.03%]
使用测试阴性设计中的疫苗接种者进行免疫相关性分析
Dean A Follmann,Lori Dodd
Dean A Follmann
Determining the effect of vaccine-induced immune response on disease risk is an important goal of vaccinology. Typically, immune correlates analyses are conducted prospectively with immune response measured shortly after vaccination and sub...
Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes [0.03%]
高维神经影像表型的贝叶斯稀疏遗传分析
Yize Zhao,Tengfei Li,Hongtu Zhu
Yize Zhao
Heritability analysis plays a central role in quantitative genetics to describe genetic contribution to human complex traits and prioritize downstream analyses under large-scale phenotypes. Existing works largely focus on modeling single ph...
Chuan Hong,Yan Wang,Tianxi Cai
Chuan Hong
Divide-and-conquer (DAC) is a commonly used strategy to overcome the challenges of extraordinarily large data, by first breaking the dataset into series of data blocks, then combining results from individual data blocks to obtain a final es...
Adaptive treatment strategies for chronic conditions: shared-parameter G-estimation with an application to rheumatoid arthritis [0.03%]
慢性疾病的适应性治疗策略：共享参数G估计及其在类风湿关节炎中的应用
Shouao Wang,Erica Em Moodie,David A Stephens et al.
Shouao Wang et al.
Most estimation algorithms for adaptive treatment strategies assume that treatment rules at each decision point are independent from one another in the sense that they do not possess any common parameters. This is often unrealistic, as the ...
Hyung Park,Eva Petkova,Thaddeus Tarpey et al.
Hyung Park et al.
Sparse additive modeling is a class of effective methods for performing high-dimensional nonparametric regression. This article develops a sparse additive model focused on estimation of treatment effect modification with simultaneous treatm...
Randomized Controlled Trial
Biostatistics (Oxford, England). 2022 Apr 13;23(2):412-429. DOI:10.1093/biostatistics/kxaa032 2022
Individualized multi-omic pathway deviation scores using multiple factor analysis [0.03%]
使用多因子分析的个性化多组学通路偏差分数
Andrea Rau,Regina Manansala,Michael J Flister et al.
Andrea Rau et al.
Malignant progression of normal tissue is typically driven by complex networks of somatic changes, including genetic mutations, copy number aberrations, epigenetic changes, and transcriptional reprogramming. To delineate aberrant multi-omic...
A decision-theoretic approach to Bayesian clinical trial design and evaluation of robustness to prior-data conflict [0.03%]
贝叶斯临床试验设计的决策理论方法及对先验-数据冲突的稳健性评估
Silvia Calderazzo,Manuel Wiesenfarth,Annette Kopp-Schneider
Silvia Calderazzo
Bayesian clinical trials allow taking advantage of relevant external information through the elicitation of prior distributions, which influence Bayesian posterior parameter estimates and test decisions. However, incorporation of historical...
Kathrin Möllenhoff,Florence Loingeville,Julie Bertrand et al.
Kathrin Möllenhoff et al.
The classical approach to analyze pharmacokinetic (PK) data in bioequivalence studies aiming to compare two different formulations is to perform noncompartmental analysis (NCA) followed by two one-sided tests (TOST). In this regard, the PK ...