Diet or medication in primary care patients with IBS: the DOMINO study - a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute [0.03%]
饮食还是药物：DOMINO研究——一项由比利时卫生保健知识中心（KCE试验计划）和罗马基金会研究所支持的IBS患者的随机对照试验
Florencia Carbone,Karen Van den Houte,Linde Besard et al.
Florencia Carbone et al.
Background: In Europe, IBS is commonly treated with musculotropic spasmolytics (eg, otilonium bromide, OB). In tertiary care, a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet pr...
Randomized Controlled Trial
Gut. 2022 Nov;71(11):2226-2232. DOI:10.1136/gutjnl-2021-325821 2022
Immature neutrophils bring anti-PD-1 therapy in NASH-HCC to maturity [0.03%]
幼稚中性粒细胞使NASH-HCC的抗PD-1治疗成熟
Michael Dudek,Frank Tacke
Michael Dudek
Recent advances in clinical practice: management of inflammatory bowel disease during the COVID-19 pandemic [0.03%]
新冠肺炎疫情期间的炎症性肠病管理近况
Simeng Lin,Louis Hs Lau,Neil Chanchlani et al.
Simeng Lin et al.
The COVID-19 pandemic has raised considerable concerns that patients with inflammatory bowel disease (IBD), particularly those treated with immunosuppressive therapies, may have an increased risk of SARS-CoV-2 acquisition, develop worse out...
Jack Leslie,John B G Mackey,Thomas Jamieson et al.
Jack Leslie et al.
Objective: Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conve...
Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer [0.03%]
聚(I:C)激活固有和适应性免疫机制，暴露了富基质的结直肠癌预防复发的治疗弱点
Shania M Corry,Amy Mb McCorry,Tamsin Rm Lannagan et al.
Shania M Corry et al.
Objective: Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant chemotherapy. ...
Immunogenomic classification of hepatocellular carcinoma patients for immune check-point inhibitors therapy: cui bono? [0.03%]
肝细胞癌患者免疫检查点抑制剂治疗的免疫组学分类：谁是受益者？
Ruben Hernaez,Matias A Avila
Ruben Hernaez
Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial [0.03%]
内镜幽门切开术治疗重度难治性胃轻瘫的疗效：一项试点、随机和假手术对照试验
Jan Martinek,Rastislav Hustak,Jan Mares et al.
Jan Martinek et al.
Objective: Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients with gastroparesis. ...
Randomized Controlled Trial
Gut. 2022 Nov;71(11):2170-2178. DOI:10.1136/gutjnl-2022-326904 2022
Alcohol predisposes obese mice to acute pancreatitis via adipose triglyceride lipase-dependent visceral adipocyte lipolysis [0.03%]
酒精通过依赖脂肪甘油三酯脂酶的内脏脂肪细胞脂解作用使肥胖小鼠易患急性胰腺炎
Xinmin Yang,Linbo Yao,Lei Dai et al.
Xinmin Yang et al.
Mechanistic insight of SARS-CoV-2 infection using human hepatobiliary organoids [0.03%]
人源肝胆器官芯片揭示SARS-CoV-2感染机制
Yi Zhao,Xiaoxue Ren,Jing Lu et al.
Yi Zhao et al.
Sana Fatima Memon,Nitin Jagtap,D Nageshwar Reddy
Sana Fatima Memon