Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases [0.03%]
阻断细胞因子白细胞介素10可增强人体结直肠癌肝转移的抗癌免疫功能
Kevin M Sullivan,Xiuyun Jiang,Prajna Guha et al.
Kevin M Sullivan et al.
Objective: Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive cellular therapy have had limited success in patients with microsatellite stable colorectal cancer liver metastases (CRLM). We sought to...
Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC [0.03%]
保护性和攻击性细菌亚群和代谢产物可改变胆管炎小鼠PSC肝胆炎症和纤维化
Muyiwa Awoniyi,Jeremy Wang,Billy Ngo et al.
Muyiwa Awoniyi et al.
Objective: Conflicting microbiota data exist for primary sclerosing cholangitis (PSC) and experimental models. Goal: define the functio...
Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models [0.03%]
细胞间和细胞基质粘附依赖性的逃逸强调了胃癌器官模型中的疾病进展
Yin Tong,Priscilla S W Cheng,Chung Sze Or et al.
Yin Tong et al.
Objective: Cell-cell (CC) and cell-matrix (CM) adhesions are essential for epithelial cell survival, yet dissociation-induced apoptosis is frequently circumvented in malignant cells. ...
Transcription factor p63, a member of the p53 family of tumour suppressors, regulates hepatic glucose metabolism [0.03%]
转录因子p63通过调控肝脏葡萄糖代谢抑制肿瘤生长
Gilles Mithieux
Gilles Mithieux
Comparison of lumen-apposing metal stents versus double-pigtail plastic stents for infected necrotising pancreatitis [0.03%]
腔内支撑金属支架与双猪尾塑料支架治疗感染性坏死性胰腺炎的比较研究
Lotte Boxhoorn,Robert C Verdonk,Marc G Besselink et al.
Lotte Boxhoorn et al.
Objective: Lumen-apposing metal stents (LAMS) are believed to clinically improve endoscopic transluminal drainage of infected necrosis when compared with double-pigtail plastic stents. However, comparative data from prosp...
Randomized Controlled Trial
Gut. 2023 Jan;72(1):66-72. DOI:10.1136/gutjnl-2021-325632 2023
COVID-19 and liver disease [0.03%]
新冠肺炎与肝病
Jean-François Dufour,Thomas Marjot,Chiara Becchetti et al.
Jean-François Dufour et al.
Knowledge on SARS-CoV-2 infection and its resultant COVID-19 in liver diseases has rapidly increased during the pandemic. Hereby, we review COVID-19 liver manifestations and pathophysiological aspects related to SARS-CoV-2 infection in pati...
The future of drug development for inflammatory bowel disease: the need to ACT (advanced combination treatment) [0.03%]
炎症性肠病的未来药物开发：开展ACT（先进联合治疗）的必要性
Silvio Danese,Virginia Solitano,Vipul Jairath et al.
Silvio Danese et al.
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice [0.03%]
饮食中的纤维素通过介导小鼠肠道菌群产生的6α-羟基胆汁酸与TGR5的信号转导来改善葡萄糖代谢
Kassem Makki,Harald Brolin,Natalia Petersen et al.
Kassem Makki et al.
Objective: Dietary fibres are essential for maintaining microbial diversity and the gut microbiota can modulate host physiology by metabolising the fibres. Here, we investigated whether the soluble dietary fibre oligofruc...
Gastric emptying study before gastric peroral endoscopic myotomy (G-POEM): can intragastric meal distribution be a predictor of success? [0.03%]
胃空腹试验在经口胃肠粘膜下肌切开术前的应用：胃内餐分布能否成为预测手术成功的指标？
Francesco Vito Mandarino,Sabrina Gloria Giulia Testoni,Alberto Barchi et al.
Francesco Vito Mandarino et al.
Desmond Leddin,M Bishr Omary,Geoffrey Metz et al.
Desmond Leddin et al.