Refining genetic and molecular classifications to facilitate breakthrough treatments in intrahepatic cholangiocarcinoma: are we there yet? [0.03%]
完善遗传和分子分类以促进肝内胆管癌突破性治疗：我们做到了吗？
Satoru Morita,Dan G Duda
Satoru Morita
Peter Fickert
Peter Fickert
Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case-control study [0.03%]
胰腺导管腺癌(PDAC)早期标志物的身体质量指数、血液检测、并存症和用药使用的时效性：一项病例对照研究
Pui San Tan,Cesar Garriga,Ashley Clift et al.
Pui San Tan et al.
Objective: Prior studies identified clinical factors associated with increased risk of pancreatic ductal adenocarcinoma (PDAC). However, little is known regarding their time-varying nature, which could inform earlier diag...
Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D) [0.03%]
肠溶胶（聚甲基硅氧烷多羟基）治疗腹泻型肠易激综合征的双盲随机安慰剂对照试验
Carol Angela Howell,Anu Kemppinen,Victoria Allgar et al.
Carol Angela Howell et al.
Objective: Irritable bowel syndrome with diarrhoea (IBS-D) is a common and challenging condition that significantly reduces quality of life. Enterosgel (polymethylsiloxane polyhydrate) is an intestinal adsorbent which seq...
Randomized Controlled Trial
Gut. 2022 Dec;71(12):2430-2438. DOI:10.1136/gutjnl-2022-327293 2022
Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma [0.03%]
基底细胞腺癌中DLL1介导的NOTCH信号转导以APE1依赖性的NF-κB活化机制进行氧化还原调控
Lei Chen,Heng Lu,Dunfa Peng et al.
Lei Chen et al.
Objective: Oesophageal adenocarcinoma (EAC) arises in the setting of Barrett's oesophagus, an intestinal metaplastic precursor lesion that can develop in patients with chronic GERD. Here, we investigated the role of acidi...
Further research needed to determine first-line therapy for IBS in primary care [0.03%]
进一步研究以确定初级保健中肠易激综合征的一线治疗方案
Anupam Rej,David S Sanders,Imran Aziz
Anupam Rej
Hepatic events associated with sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes: a nationwide cohort study [0.03%]
钠-葡萄糖共转运蛋白2抑制剂导致的肝事件与2型糖尿病患者的临床表现相关性：基于全国队列的研究结果
Sungho Bea,Han Eol Jeong,Sohee Park et al.
Sungho Bea et al.
Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction [0.03%]
京都国际共识报告：胃食管结合部的解剖、病理生理及临床意义
Kentaro Sugano,Stuart Jon Spechler,Emad M El-Omar et al.
Kentaro Sugano et al.
Objective: An international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of the cardiac gland, (3)...
Jean-François Dufour,Quentin M Anstee,Elisabetta Bugianesi et al.
Jean-François Dufour et al.
Non-alcoholic steatohepatitis is becoming the most important aetiology for advanced liver disease. There has been important progress in the field in recent years and the complexity of the pathophysiology of NASH is better understood. Multip...