Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer [0.03%]
组蛋白乳酰化驱动的反馈环调节胰腺癌中的胆固醇相关免疫抑制
Jing Yang,Xiaoning Yu,Mingming Xiao et al.
Jing Yang et al.
Background: Pancreatic cancer exhibits limited clinical responses to immunotherapy, highlighting the need for new strategies to counteract its immunosuppressive microenvironment. Although metabolic reprogramming and epige...
DUOX2-mediated gut barrier dysfunction: a preclinical mechanism in IBD pathogenesis? [0.03%]
DUOX2介导的肠道屏障功能障碍：IBD发病机制中的一个动物模型机制？
Cong Phi Dang,Kenneth Croitoru,Williams Turpin
Cong Phi Dang
Differential HCC risk among HBV indeterminate types at baseline and by phase transition [0.03%]
基线时和相变过程中HBV不确定类型患者发生HCC风险的差异性研究
Rui Huang,Huy N Trinh,Satoshi Yasuda et al.
Rui Huang et al.
Background: Patients with chronic hepatitis B (CHB) with indeterminate phase make up a diverse cohort with likely different outcomes. Objective: ...
Response to the letter to the editor 'revisiting lipid dysregulation in colorectal cancer: critical appraisal of pro-inflammatory bias and therapeutic implications' [0.03%]
关于编辑部来信“重新探讨结直肠癌中的脂质代谢紊乱：对促炎偏向及治疗意义的再评价”的回应
Ramani Soundararajan,Ganesh Halade,Timothy J Yeatman
Ramani Soundararajan
Prophylactic clip closure after endoscopic submucosal dissection of large flat and sessile colorectal polyps: a multicentre randomised controlled trial (EPOC trial) [0.03%]
大型扁平息肉和无蒂息肉内镜下粘膜下剥离术的预防性夹闭：多中心随机对照试验(EPOC试验)
Akihiro Miyakawa,Yuzuru Tamaru,Takeshi Mizumoto et al.
Akihiro Miyakawa et al.
Background: Prophylactic clip closure after endoscopic mucosal resection reduces delayed bleeding in large and proximal colon lesions; however, evidence regarding its effectiveness in colorectal endoscopic submucosal diss...
Toxic microbiome and progression of chronic kidney disease: insights from a longitudinal CKD-Microbiome Study [0.03%]
慢性肾脏病的有毒微生物组及疾病进展：CKD-微生物纵向研究的新见解
Manolo Laiola,Laetitia Koppe,Amine Larabi et al.
Manolo Laiola et al.
Background: The gut microbiota has been linked to non-communicable diseases, including chronic kidney disease (CKD). However, the relationships between gut microbiome composition changes, uraemic toxins (UTs) accumulation...
Xian Xing,Si-Di Wang,Jin-Lin Yang et al.
Xian Xing et al.
Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating GNLY +CD8+ T cells [0.03%]
肠道共生菌代谢产物丁酸盐通过激活肿瘤浸润性GNLY⁺CD8⁺T细胞增强抗PD-1在结直肠癌患者源类器官中的疗效
Yongxin Zhang,Wu Song,Lei Zhou et al.
Yongxin Zhang et al.
A black liver [0.03%]
黑色的肝脏
Huang Xing
Huang Xing
Commensal Bacteroides T6SS alleviate GI-aGVHD via mediating gut microbiota composition and bile acids metabolism [0.03%]
共生拟杆菌T6SS通过介导肠道菌群组成和胆汁酸代谢来缓解GI-aGVHD
Pengfei Li,Qiyi Lei,Xinghao Yu et al.
Pengfei Li et al.
Background: Gastrointestinal acute graft-versus-host disease (GI-aGVHD) is one of the main complications of patients undergoing allogenic haematopoietic stem cell transplantation (allo-HSCT). A deeper understanding of the...