First-Generation TTR Silencing Therapies in Hereditary Transthyretin Amyloidosis With Polyneuropathy: Real-World Insights From a German Single-Referral Center [0.03%]
德国单转诊中心遗传性转甲状腺素蛋白淀粉样变性多发神经病患者中第一代TTR沉默疗法的真实世界见解
Marilin S Koch,Fabian Aus dem Siepen,Ute Hegenbart et al.
Marilin S Koch et al.
Background: Hereditary transthyretin (ATTRv) amyloidosis is a rare, genetically heterogeneous disease leading to an unstable configuration of transthyretin (TTR) and hence irregular deposition of TTR amyloid fibrils. The ...
Falls in Functional Neurological Disorder: Prevalence, Risk Factors and Clinical Implications [0.03%]
功能神经性障碍中的跌倒：流行病学、危险因素及临床意义
Zahra Mohammadi,Amirreza Keyvanfar,Rory Higgins et al.
Zahra Mohammadi et al.
Background: Functional neurological disorder (FND) is a disabling condition often presenting with motor impairments, including gait disturbance and postural instability. Data on the prevalence and predictors of falls in p...
Pharmacological Interventions for Hereditary Transthyretin-Related Amyloidosis With Polyneuropathy: Systematic Review and Network Meta-Analysis [0.03%]
遗传性转甲状腺素蛋白介导的多发性神经病性淀粉样变的药理学干预措施：系统评价和网络meta分析
Gonçalo S Duarte,Tiago Luís Gonçalves Neves Machado,Filipe B Rodrigues et al.
Gonçalo S Duarte et al.
Background: We used network meta-analyses to evaluate the pharmacological interventions for Hereditary Transthyretin-related Amyloidosis with Polyneuropathy (ATTRv-PN). ...
Progression to Wheelchair in Secondary Progressive Multiple Sclerosis and Impact of Siponimod: Post Hoc Analyses From the EXPAND Study [0.03%]
继发进展型多发性硬化症中使用轮椅的进展以及西尼莫德的影响：来自EXPAND研究的事后分析
Patrick Vermersch,Sophie Arnould,Ralf Gold et al.
Patrick Vermersch et al.
Background: Delaying time to requiring a wheelchair in people living with MS is an important treatment goal to maintain quality of life and guard against increased healthcare costs. In this post hoc analysis, the effects ...
Optic Nerve Lesion Volume, White Matter Hyperintensities, and Brain Volumetrics in Multiple Sclerosis: A Multi-Sequence MRI-Based Analysis [0.03%]
多发性硬化症视神经病变体积、白质高信号和脑容积的磁共振成像研究
Adrian Korbecki,Tomasz Konopczyński,Oktawian Hawro et al.
Adrian Korbecki et al.
Objectives: To examine the association between optic nerve lesion volume (ONLV) on double inversion recovery (DIR) MRI and other imaging biomarkers of disease burden in multiple sclerosis (MS), including white matter hype...
Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review [0.03%]
机器学习在中枢性过度睡眠障碍诊断和鉴别的系统评价研究
Annina Helmy,Livia G Fregolente,Marc von Gernler et al.
Annina Helmy et al.
Background and purpose: Central disorders of hypersomnolence (CDH) are, except for Narcolepsy Type 1 (NT1), difficult to diagnose and manage because of overlapping features and the lack of reliable biomarkers. Machine lea...
Impact of Intracranial Atherosclerosis and Cerebral Small Vessel Disease on Overt Vascular Events During Antithrombotic Therapy [0.03%]
颅内动脉粥样硬化和脑小血管病对抗血栓治疗期间的卒中类型及临床结局的影响
Kaori Miwa,Masatoshi Koga,Kanta Tanaka et al.
Kaori Miwa et al.
Introduction: To investigate the association of intracranial atherosclerotic disease (ICAD), alone and comorbid with cerebral small vessel disease (SVD), with ischemic or hemorrhagic events in patients receiving antithrom...
Observational Study
European journal of neurology. 2026 Jun;33(6):e70635. DOI:10.1111/ene.70635 2026
Prevalence and Characteristics of Cardiac Arrhythmia in Duchenne Muscular Dystrophy: A Retrospective, Single-Center Holter Electrocardiographic Monitoring Study [0.03%]
杜氏肌营养不良心电图监测研究报告：一项回顾性单中心研究
Ryo Sugiyama,Eri Takeshita,Yu Aihara et al.
Ryo Sugiyama et al.
Background: In Duchenne muscular dystrophy (DMD), cardiac causes account for approximately 30% of all deaths. Therefore, evaluating cardiac function in older patients is important. In addition, current recommendations adv...
Severe Immune-Related Neurological Adverse Events Associated With Immune Checkpoint Inhibitor Treatment: A Retrospective Single-Center Study [0.03%]
免疫检查点抑制剂治疗相关的严重免疫相关神经系统不良事件：一项回顾性单中心研究
Anna Grisold,Angelika M Starzer,Sara Silvaieh et al.
Anna Grisold et al.
Background: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of various malignancies. The resulting activation of the immune system may lead to neurological immune-related adverse events (n-irAEs). He...
Longitudinal Trajectories in Essential Tremor: Evidence From A Seven-Year Follow-Up of Motor and Non-Motor Symptoms [0.03%]
基于七年间随访的特发性震颤纵向轨迹：运动及非运动症状证据
Luca Angelini,Daniele Birreci,Anna Sofia Grandolfo et al.
Luca Angelini et al.
Background: Essential tremor (ET) is a common movement disorder characterized by heterogeneous features, though the rate and pattern of worsening are variable. Longitudinal data combining clinical and objective motor meas...