Recent Advances in Interventions Targeting Remyelination and a Systematic Review of Remyelinating Effects of Approved Disease-Modifying Treatments for Multiple Sclerosis [0.03%]
靶向少突胶质细胞前体细胞介导的少突胶质细胞生成的治疗干预最新进展及批准用于多发性硬化症的疾病修正疗法的少突胶质细胞生成作用系统评价
Anna-Victoria De Keersmaecker,Eline van Doninck,Inez Wens et al.
Anna-Victoria De Keersmaecker et al.
Background: Regenerative strategies in progressive multiple sclerosis (MS) pose a significant unmet need. Combining immunomodulatory treatment with remyelinating interventions to target the complex underlying pathogenesis...
Miglustat in Alzheimer's Disease Associated With Heterozygous NPC1 Mutation: Exploratory Case Series and Preliminary Findings [0.03%]
异染性脑白质营养不良突变引起的阿尔茨海默病患者使用米格鲁司他治疗的探索性病例系列和初步结果分析
Diego Lopergolo,Daniele Gasparini,Silvia Bianchi et al.
Diego Lopergolo et al.
Introduction: Several studies have previously demonstrated an increased risk of dementia and brain amyloid deposition in individuals with heterozygous NPC1 mutations. Moreover, in a recent study, we identified the first f...
Reference-Group Adjusted Behavioural Dysfunction Questionnaire Score Discriminates Highly Behavioural-Variant Frontotemporal Dementia From Major Depressive Disorder and Alzheimer's Disease Dementia [0.03%]
参照群体行为紊乱问卷评分可将以行为变异为主的额颞叶痴呆与重度抑郁症和阿尔茨海默病性痴呆相鉴别
Anna Semenkova,Olivier Piguet,Andreas Johnen et al.
Anna Semenkova et al.
Background: Given the fact that behavioural variant frontotemporal dementia (bvFTD) is characterised by behavioural disorders, the assessment of these disorders is essential for early diagnosis of bvFTD. In this regard, t...
Measures of Comorbidities and Frailty in Multiple Sclerosis-Systematic Review on Evidence and Applicability of Utilized Scoring Systems in Clinical Routine and Real-World Data [0.03%]
多发性硬化症共病和脆弱测量方法的系统评价：临床常规和现实世界数据中应用评分系统的证据及适用性
Marie Louise Aicher,Fabian Föttinger,Robert Hoepner et al.
Marie Louise Aicher et al.
Background: In multiple sclerosis (MS), comorbidities and frailty are receiving increasing attention influencing disease course, treatment and quality of life. The objective of this literature review is to evaluate the ev...
Corneal Confocal Microscopy to Diagnose Peripheral Neuropathy: A Systematic Review and Meta-Analysis [0.03%]
角膜共焦显微镜在诊断周围神经病变中的应用：系统性回顾和荟萃分析
Ioannis N Petropoulos,Omar A Madani,Hoda Y Gad et al.
Ioannis N Petropoulos et al.
Background and objectives: Peripheral neuropathy (PN) may be diagnosed late or may remain undiagnosed. Studies have shown that measurement of corneal nerve fiber length (CNFL) using corneal confocal microscopy (CCM) may h...
The Medical Burden of Drug-Resistant Epilepsy in an Outpatient Clinic of a Tertiary Hospital: A Prospective Study Based on Real-World Evidence [0.03%]
基于真实世界证据的三级医院门诊难治性癫痫疾病负担的前瞻性研究
Maria Grávalos,Jordi Mayol,Elena Fonseca et al.
Maria Grávalos et al.
Objective: Drug-resistant epilepsy (DRE) leads to a range of medical and social consequences, which contribute to a high disease burden. We aimed to describe factors associated with an increased medical burden in DRE. ...
Stroke in Fabry Disease: Identification of Risk Factors for Stroke in a Large Single-Centre Cohort [0.03%]
法布雷病卒中风险因素的单中心大样本研究
David Moreno-Martinez,Sara Lucas-Del-Pozo,Lucia Lavalle et al.
David Moreno-Martinez et al.
Objectives: Risk factors for stroke in Fabry disease (FD) are not precisely known. This study presents a retrospective cohort analysis from one reference centre in the United Kingdom to determine risk factors for stroke a...
Impact of Erenumab on Comorbid Depression, Anxiety, and Sleep Quality in Migraine: A Registry for Migraine (REFORM) Study [0.03%]
偏头痛共病抑郁、焦虑和睡眠质量的依瑞肭肽疗效：来自偏头痛登记研究(REFORM)的数据
Bianca Raffaelli,Janu Thuraiaiyah,Rune Häckert Christensen et al.
Bianca Raffaelli et al.
Background: Migraine frequently co-exists with psychiatric comorbidities, including anxiety, depression, and sleep disturbances. Erenumab, a monoclonal antibody targeting the calcitonin gene-related peptide receptor, effe...
Cognitive Reserve in Amyotrophic Lateral Sclerosis: A 2-[18F]FDG-PET Study on Sex-Related Differences [0.03%]
ALS中基于性别差异的认知代偿能力的2-［18F］FDG-PET研究
Antonio Canosa,Stefano Callegaro,Umberto Manera et al.
Antonio Canosa et al.
Background: Cognitive reserve (CR) applies to ALS-related cognitive impairment and education is a CR proxy. The influence of sex on CR in ALS is unclear. ...
Joint Modelling of Growth and Motor Function Centiles in Corticosteroids Treated Boys With Duchenne Muscular Dystrophy [0.03%]
接受糖皮质激素治疗的杜氏肌营养不良症男孩生长和运动功能百分位数的联合建模
Georgia Stimpson,Deborah Ridout,Amy Wolfe et al.
Georgia Stimpson et al.
Background: Corticosteroid (CS) treated boys with DMD display higher rates of height stunting, higher weight gain, improved motor function scores and delayed loss of ambulation compared to untreated patients. However, the...