Real-World Use of Cenobamate in Paediatric Drug-Resistant Epilepsy: Long-Term Efficacy, Safety, and Co-Medication Adjustment [0.03%]
儿科难治性癫痫长期使用cenobamate的现实世界应用：有效性和安全性以及联用药物的调整
Tiziana Pisano,Simona Balestrini,Alessandra Boncristiano et al.
Tiziana Pisano et al.
Background: We evaluated the real-world efficacy, tolerability, treatment retention, and quality-of-life effects of cenobamate in paediatric drug-resistant epilepsy. ...
Over-Representation of TTN Truncating Variants in a Finnish Cohort of Patients With Axial Myopathy [0.03%]
芬兰轴向肌病患者中TTN截断变异的过代表
Maria Francesca Di Feo,Giuliana Capece,Marco Savarese et al.
Maria Francesca Di Feo et al.
Background: Axial myopathies present with late onset selective paravertebral weakness causing bent spine/camptocormia or dropped head, and the genetic basis remains currently only partially understood. Truncating variants...
Claudio L A Bassetti,Luisa S Welter,Mateo Montes-Martinez et al.
Claudio L A Bassetti et al.
Background: Sleep and sleep disorders (SD) have a major impact on brain (neurological and psychiatric), body and societal health. Despite this, the epidemiological and economic burden of SD have not been sufficiently anal...
Associated Autoimmunity in Myasthenia Gravis in Denmark: A Nationwide Case-Control Study [0.03%]
丹麦重症肌无力相关自身免疫的全国病例对照研究
Josefine Jul Jarbæk Nielsen,Lotte Sahin Levison,Henning Andersen
Josefine Jul Jarbæk Nielsen
Background: Myasthenia gravis (MG) is an autoantibody-mediated neuromuscular disease often co-occurring with other autoimmune diseases (ADs). We aimed to determine the temporal relationship between other ADs and MG. ...
Biomarkers of Cardioembolic Stroke in Thrombus Composition: Diagnostic Value of DNA and Fibrin Content [0.03%]
血栓组成中的心源性脑卒中生物标志物：DNA和纤维蛋白含量的诊断价值
Jéromine Fasille,Mialitiana Solo Nomenjanahary,Dorothée Faille et al.
Jéromine Fasille et al.
Background and purpose: Cryptogenic strokes, accounting for 25%-40% of ischemic strokes, represent a major challenge in secondary prevention due to their uncertain etiology and high recurrence risk. Identifying biomarkers...
Screening Value of the I-Douleur Neuropathique 4 Questionnaire for Small Fibre Neuropathy in Patients With Painful Syndromes: Insights From 872 Skin Biopsies [0.03%]
I-Douleur神经病理性疼痛4项问卷筛查小纤维周围神经病变的价值：来自872例皮肤活检的启示
Simon Frachet,Emilie Soust,Laurence Richard et al.
Simon Frachet et al.
Background: Small-fibre neuropathy (SFN), which is defined by the sole involvement of small sensory fibres, often leads to neuropathic pain. The diagnosis of SFN relies on clinical, neurophysiologic, and morphologic abnor...
The Epilepsy-Desirability of Outcome Ranking (DOOR) as a Multi-Faceted Consumer-Informed Outcome Measure for Epilepsy Clinical Trials [0.03%]
作为多维度的患者意愿结果测量方法的发作性障碍-意愿结果等级( DOOR )及其在发作性障碍临床试验中的应用
Lucy Vivash,Hannah Johns,Terence J O Brien et al.
Lucy Vivash et al.
Background: New drug trials in drug resistant epilepsy are typically powered to detect changes in seizure frequency as the primary endpoint, without integrating other treatment-associated benefits and harms. We developed ...
Randomized Controlled Trial
European journal of neurology. 2026 Feb;33(2):e70531. DOI:10.1111/ene.70531 2026
Prevalence and Impact of Probable REM Sleep Behavior Disorder in Essential Tremor: A Multicenter Cross-Sectional Study [0.03%]
多中心横断面研究发现原发性震颤伴可能的快动眼睡眠行为异常的患病率及影响因素
Yuzheng Wang,Mingqiang Li,Runcheng He et al.
Yuzheng Wang et al.
Objectives: To investigate the prevalence of probable REM sleep behavior disorder (pRBD) in essential tremor (ET), identify associated risk factors, and evaluate its effects on motor and non-motor symptoms. ...
Meta-Analysis
European journal of neurology. 2026 Feb;33(2):e70516. DOI:10.1111/ene.70516 2026
Vascular Comorbidities and an Increased Comorbidity Score Are Associated With Disability and Disability Progression in Secondary Progressive Multiple Sclerosis [0.03%]
血管共病和增加的共病评分与 secondary progressive 多发性硬化症致残及病情进展有关
Nevin A John,Yingtong Li,Floriana De Angelis et al.
Nevin A John et al.
Background: Vascular risk factors are associated with increased disease activity and disability progression in multiple sclerosis (MS). This has been studied mainly in cohorts with relapsing-remitting MS. However, the ass...
Randomized Controlled Trial
European journal of neurology. 2026 Feb;33(2):e70517. DOI:10.1111/ene.70517 2026
The PERISCOPE Cohort: A Retrospective Study of Clinicopathological and TRAF7 Genetic Findings in Intraneural Perineurioma [0.03%]
PERISCOPE队列研究：神经内膜细胞瘤的临床病理及TRAF7遗传学特征的回顾性分析
Eduardo Boiteux Uchôa Cavalcanti,Alessandra de La Rocque Ferreira,Nilo Sakai Júnior et al.
Eduardo Boiteux Uchôa Cavalcanti et al.
Background: Intraneural perineurioma (INP) is a rare, benign peripheral nerve sheath tumour that typically presents in adolescence or early adulthood as a slowly progressive, motor-predominant mononeuropathy or plexopathy...