Feminization of the Blood-Brain Barrier Changes the Brain Transcriptome of Drosophila melanogaster Males [0.03%]
雌性化的血脑屏障会改变黑腹果蝇的雄性大脑转录组
Danyel S Davis,Warda Hashem,Chamala Lama et al.
Danyel S Davis et al.
Beyond its crucial role as a tight barrier to protect the nervous system, the Blood-Brain Barrier (BBB) is increasingly being recognized for its physiological processes that affect brain function and behavior. In Drosophila melanogaster, th...
Genetic Risk Profiles for Atherosclerosis and Venous Thromboembolism in Azorean and Mainland Portuguese Populations: A Comparative Analysis [0.03%]
亚速尔群岛和葡萄牙半岛人群动脉粥样硬化和静脉血栓栓塞的遗传风险谱系：一项比较分析
Luisa Mota-Vieira,Joana Duarte,Xavier Catena et al.
Luisa Mota-Vieira et al.
The frequency of specific variants associated with the risk of developing cardiovascular diseases has been extensively studied through genome-wide association studies (GWASs). Differences between populations may be caused by the interaction...
Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal [0.03%]
评估来自尼泊尔高海拔地区的野生灵芝生物活性化合物、抗氧化活性和抗癌潜力
Ishor Thapa,Ashmita Pandey,Sunil Tiwari et al.
Ishor Thapa et al.
Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type-water, ethanol, methanol, and acetone-on extraction efficiency and biological activity. Extra...
Fyn Kinase: A Potential Target in Glucolipid Metabolism and Diabetes Mellitus [0.03%]
风激酶：糖脂代谢及糖尿病治疗的新靶点
Ruifeng Xiao,Cong Shen,Wen Shen et al.
Ruifeng Xiao et al.
Fyn is widely involved in diverse cellular physiological processes, including cell growth and survival, and has been implicated in the regulation of energy metabolism and the pathogenesis of diabetes mellitus through multiple pathways. Fyn ...
Repurposing a Lipid-Lowering Agent to Inhibit TNBC Growth Through Cell Cycle Arrest [0.03%]
一种降脂药物的新用途通过细胞周期阻滞抑制三阴性乳腺癌生长
Yi-Chiang Hsu,Kuan-Ting Lee,Sung-Nan Pei et al.
Yi-Chiang Hsu et al.
Triple-negative breast cancer (TNBC) is a highly aggressive and therapeutically challenging subtype of breast cancer due to its lack of estrogen receptors, progesterone receptors, and HER2 (Human epidermal growth factor receptor 2) expressi...
Orange Allergy Beyond LTP: IgE Recognition of Germin-like Proteins in Citrus Fruits [0.03%]
橙子过敏超越LTP：柑橘果实中Germin-like蛋白的IgE识别反应
M Soledad Zamarro Parra,Montserrat Martínez-Gomaríz,Alan Hernández et al.
M Soledad Zamarro Parra et al.
Orange allergy is estimated to account for up to 3-4% of food allergies. Major allergens identified in orange (Citrus sinensis) include Cit s 1 (germin-like protein) and Cit s 2 (profilin), while Cit s 3 (non-specific lipid transfer protein...
Analysis of Endoplasmic Reticulum Stress Proteins in Spermatogenic Cells After Paclitaxel Administration [0.03%]
紫杉醇致生精细胞内质网应激蛋白变化分析
Suna Karadeniz Saygılı,Meryem Cansu Sahin,Fulya Yukcu et al.
Suna Karadeniz Saygılı et al.
Background/objectives: The aim of this research is to analyze the effect of paclitaxel on endoplasmic reticulum (ER) stress in spermatogenic cells. Method...
The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota [0.03%]
美洲蠊提取物通过调节FOXO/PI3K/AKT信号通路和皮肤微生态促进小鼠斑秃毛发再生
Tangfei Guan,Xin Yang,Canhui Hong et al.
Tangfei Guan et al.
Alopecia, a prevalent dermatological disorder affecting over half of the global population, is strongly associated with psychological distress. Extracts from Periplaneta americana (L. PA), a medicinal insect resource, exhibit pharmacologica...
Obesity-Induced MASLD Is Reversed by Capsaicin via Hepatic TRPV1 Activation [0.03%]
辣椒素通过激活肝TRPV1逆转肥胖诱导的MASLD
Padmamalini Baskaran,Ryan Christensen,Kimberley D Bruce et al.
Padmamalini Baskaran et al.
Background and objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive liver disorder associated with metabolic risk factors such as obesity, type 2 diabetes, and cardiovascular disea...
Multifunctional Dermatological Effects of Whole-Plant Bassia scoparia Extract: Skin Repair and Protection [0.03%]
全枝五蕊花提取物的多功能护肤功效研究：修护与防护
Seogyun Jeong,Hye-Been Kim,Dong-Geol Lee et al.
Seogyun Jeong et al.
Bassia scoparia (Syn. Kochia scoparia (L.) Schrad.) is a medicinal plant whose fruit, Kochiae Fructus, has been extensively studied for its dermatological applications. This study focused on extracts from the whole plant B. scoparia (WPBS),...