Convergent and Divergent Mitochondrial Pathways as Causal Drivers and Therapeutic Targets in Neurological Disorders [0.03%]
神经疾病中线粒体通路的汇聚与发散作为因果驱动因素和治疗靶点
Yanan Du,Sha-Sha Fan,Hao Wu et al.
Yanan Du et al.
Mitochondrial dysfunction is implicated across a spectrum of neurological diseases, yet its causal role and mechanistic specificity remain unclear. This study employed a multi-modal integrative analysis of mitochondrial gene expression in A...
Neuroprotective Potential of Phytocompounds in the Treatment of Dementia: The State of Knowledge from the Scopolamine-Induced Animal Model of Alzheimer's Disease [0.03%]
植物化合物治疗痴呆的神经保护潜力：来源于胡椒碱诱导动物模型的知识状态阿尔茨海默病)
Joanna Szala-Rycaj,Mirosław Zagaja,Aleksandra Szewczyk et al.
Joanna Szala-Rycaj et al.
Dementia is a broad category of neurodegenerative pathologies characterized by a progressive decline in two or more cognitive domains, including memory, language, executive and visuospatial functions, personality, and behavior, resulting in...
Computational Exploration of Bacterial Compounds Targeting Arginine-Specific Mono-Adp-Ribosyl-Transferase 1 (Art1): A Pathway to Novel Therapeutic Anticancer Strategies [0.03%]
计算探索靶向精氨酰特异单腺苷二磷酸核糖转移酶1（ART1）的细菌化合物：一种新型抗癌治疗策略的途径
Nedjwa Mansouri,Ouided Benslama,Sabrina Lekmine et al.
Nedjwa Mansouri et al.
Cancer is a multifaceted and life-threatening disease characterized by the unregulated proliferation of malignant cells. Developing new therapies and diagnostic methods for cancer remains a critical focus of research. Proteins involved in c...
Genome-Wide Identification and Expression Analysis of the GH19 Chitinase Gene Family in Sea Island Cotton [0.03%]
海岛棉GH19家族基因的全基因组鉴定及表达分析
Jingjing Ma,Yilei Long,Jincheng Fu et al.
Jingjing Ma et al.
In this study, GH19 chitinase (Chi) gene family was systematically identified and characterized using genomic assemblies from four cotton species: Gossypium barbadense, G. hirsutum, G. arboreum, and G. raimondii. A suite of analyses was per...
Hans P Nazarloo,Marcy A Kingsbury,Hannah Lamont et al.
Hans P Nazarloo et al.
The purpose of this article is to examine a previously unrecognized role for the vasopressin-oxytocin (VP-OT) system in mammalian "stress-response hormesis." The current review adds hormesis to the long list of beneficial effects of OT. Hor...
Phytochemical Constituents from Cercidiphyllum japonicum Exhibit Bioactive Potential Against Skin Aging and Inflammation in Human Dermal Fibroblasts [0.03%]
Cercidiphyllum japonicum的植物化学成分对人类皮肤成纤维细胞抗皱和抗炎活性的研究
Minseo Kang,Sanghyun Lee,Dae Sik Jang et al.
Minseo Kang et al.
With increasing interest in natural therapeutic strategies for skin aging, plant-derived compounds have gained attention for their potential to protect against oxidative stress and inflammation. In this study, we investigated the anti-aging...
Physical Activity and Metabolic Disorders-What Does Gut Microbiota Have to Do with It? [0.03%]
运动与代谢病-肠道菌群有何关系？
Aneta Sokal-Dembowska,Ewelina Polak-Szczybyło,Kacper Helma et al.
Aneta Sokal-Dembowska et al.
Obesity, type 2 diabetes mellitus (T2DM) and steatohepatitis associated with metabolic dysfunction (MASLD) are on the rise and pose serious health challenges worldwide. In recent years, researchers have gained a better understanding of the ...
Molecular and Glycosylation Pathways in Osteosarcoma: Tumor Microenvironment and Emerging Strategies Toward Personalized Oncology [0.03%]
骨肉瘤中的分子和糖基化通路：肿瘤微环境及个性化医疗的新兴策略
Georgian Longin Iacobescu,Antonio-Daniel Corlatescu,Horia Petre Costin et al.
Georgian Longin Iacobescu et al.
Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents, which is also considered an aggressive disease due to its rapid growth rate, ability to metastasize early, and complex and heterogeneous tumor microen...
MvAl-MFP: A Multi-Label Classification Method on the Functions of Peptides with Multi-View Active Learning [0.03%]
基于多视图主动学习的肽功能多标签分类方法研究
Yuxuan Peng,Jicong Duan,Yuanyuan Dan et al.
Yuxuan Peng et al.
The rapid expansion of peptide libraries and the increasing functional diversity of peptides have highlighted the significance of predicting the multifunctional properties of peptides in bioinformatics research. Although supervised learning...
An Integrated Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and Experimental Validation Study to Investigate the Potential Mechanism of Isoliquiritigenin in the Treatment of Ischemic Stroke [0.03%]
基于网络药理学、分子对接、分子动力学模拟及实验验证的异黄酮治疗缺血性脑卒中潜在机制研究
Hang Yuan,Yuting Hou,Yuan Jiao et al.
Hang Yuan et al.
Isoliquiritigenin (ISL) is a type of chalcone that widely exists in medicinal plants of the Leguminosae family and exhibits a remarkable anti-ischemic stroke (IS) effect. However, the anti-IS mechanisms of ISL remain to be systematically el...