Balancing Microglial Density and Activation in Central Nervous System Development and Disease [0.03%]
小胶质细胞密度和活化在中枢神经系统发育和疾病中的平衡作用
Shunqi Wang,Liangjing Pan,Chong Sun et al.
Shunqi Wang et al.
Microglia, the resident immune cells of the central nervous system, play multifaceted roles in both health and disease. During development, they regulate neurogenesis and refine neural circuits through synaptic pruning. In adulthood, microg...
Key Roles of Brown, Subcutaneous, and Visceral Adipose Tissues in Obesity and Insulin Resistance [0.03%]
肥胖症和胰岛素抵抗中棕色脂肪组织、皮下脂肪组织和内脏脂肪组织的关键作用
Maria-Zinaida Dobre,Bogdana Virgolici,Olivia Timnea
Maria-Zinaida Dobre
Adipose tissue is a dynamic and heterogeneous organ with distinct depots that play divergent roles in metabolic regulation. This review highlights the functional differences between brown, subcutaneous, and visceral adipose tissue, and thei...
Exploration of the Mechanisms of Acorus tatarinowii in the Treatment of Major Depressive Disorder Based on Network Pharmacology and Molecular Docking Techniques [0.03%]
基于网络药理学和分子对接技术探究石菖蒲治疗抑郁症的作用机制
Li Han,Siwen Wei,Rong Wang et al.
Li Han et al.
Objective: To elucidate the molecular targets and mechanisms by which Acorus tatarinowii exerts therapeutic effects in major depressive disorder (MDD) using network pharmacology and molecular docking approaches. ...
Multidimensional Transcriptomics Reveals the Key Genes and Pathways Regulating the Acidity of Apples [0.03%]
多维度转录组学揭示了调控苹果酸味的关键基因和途径
Wenyuan Yang,Hang Yu,Lian Tao et al.
Wenyuan Yang et al.
Low-acid apples are popular among consumers, but the mechanisms behind the complex differences in acidity among varieties that are caused by high altitude are not clear. In this study, we used the 'Golden Delicious' apple and its superior v...
Rho-Associated Kinase Inhibitor Fasudil Protects from Sepsis-Induced Acute Kidney Injury in Rat via Suppressing STAT-3 and NLRP-3 Pathway [0.03%]
rho连接素相关激酶抑制剂 fasudil通过抑制 STAT-3 和 NLRP-3 信号通路保护内毒素诱导的急性肾损伤
Neslihan Şahin,Ejder Saylav Bora,Osman Sezer Çınaroğlu et al.
Neslihan Şahin et al.
Sepsis-associated acute kidney injury (S-AKI) is a severe complication in critically ill patients, marked by inflammation, oxidative stress, and renal dysfunction. This study aimed to evaluate the renoprotective effects of Fasudil (Fas), a ...
Computational Modelling of Tunicamycin C Interaction with Potential Protein Targets: Perspectives from Inverse Docking with Molecular Dynamic Simulation [0.03%]
基于反向对接的分子动力学模拟计算模型构建塔他拉霉素C与潜在蛋白靶点的作用模式及其作用位点稳定性研究视角
Vivash Naidoo,Ikechukwu Achilonu,Sheefa Mirza et al.
Vivash Naidoo et al.
Protein glycosylation plays a crucial role in cancer biology, influencing essential cellular processes such as cell signalling, immune recognition, and tumour metastasis. Therefore, this study highlights the therapeutic potential of targeti...
Mechanistic Insights into the Anti-Hepatocellular Carcinoma Effects of ACY-1215: p53 Acetylation and Ubiquitination Regulation [0.03%]
ACY-1215抗肝癌作用的机制研究：p53乙酰化和泛素化的调控
Yi Yin,Yutong Du,Yiting Xu et al.
Yi Yin et al.
As a major global health challenge, hepatocellular carcinoma (HCC) still faces substantial limitations in its treatment options. This study investigates the anti-HCC potential of ACY-1215, a selective Histone deacetylase 6 (HDAC6) inhibitor...
Editorial for Special Issue "Molecular Studies of Female Pregnancy Disorders" [0.03%]
特刊：“女性妊娠障碍的分子研究”编者按
Alicia Rodríguez Barbero
Alicia Rodríguez Barbero
Pregnancy is a complex biological process that requires precise molecular regulation to ensure maternal and fetal health [...].
The 50-nm Free Vesicles Visible in Saccharomyces cerevisiae Are Not COPII-Dependent [0.03%]
酿酒酵母中可见的50nm游离小泡不依赖于COPII
Alexander A Mironov,Aurora Fusella,Galina V Beznoussenko
Alexander A Mironov
According to the current dogma, ER-Golgi transport is mediated by COPII-coated vesicles. However, numerous contradictions have emerged in this field. In this study, we demonstrate that Saccharomyces cerevisiae contains three distinct types ...
Biological Characteristics and Genomic Analysis of Acinetobacter nosocomialis Lytic Phage XC1 [0.03%]
阿克托邦医院适应菌噬菌体XC1的生物学特性及基因组分析
Chuhan Wang,Shuchuan Zhao,Hailin Jiang et al.
Chuhan Wang et al.
This study aims to isolate and characterize the lytic phage XC1 targeting Acinetobacter nosocomialis and systematically analyze its biological properties and genomic structure, providing theoretical support for developing novel treatments a...