Linolenic Acid Inhibits Cancer Stemness and Induces Apoptosis by Regulating Nrf2 Expression in Gastric Cancer Cells [0.03%]
亚麻酸通过调节Nrf2表达抑制胃癌干细胞特性并诱导凋亡
Jen-Lung Chen,Yi-Shih Ma,Kuen-Jang Tsai et al.
Jen-Lung Chen et al.
Although chemotherapy is the preferred treatment for gastric cancer, the therapeutic drugs currently available have limited efficacy and severe side effects. Cancer stem cells within tumor masses have the distinctive properties of self-rene...
Biochemical Battle: Influence of Omega-6 Fatty Acids on the Formation of DNA Adducts with 4-HNE [0.03%]
欧米茄-6脂肪酸对4-羟基壬烯醛(DNA加合物)形成的影响
Edyta Błaszczyk,Bolesław T Karwowski
Edyta Błaszczyk
While omega-6 fatty acids play an important role in normal cell function, their excess in the diet is associated with an increased risk of developing diseases such as obesity, non-alcoholic fatty liver disease (NAFLD), inflammatory bowel di...
Integrated Transcriptomic and Metabolomic Analyses Shed Light on the Regulation of Aromatic Amino Acid Biosynthesis in a Novel Albino Tea (Camellia sinensis) Mutation [0.03%]
整合转录组和代谢组分析揭示了新型白化茶（Camellia sinensis）突变体中芳香族氨基酸生物合成的调控机制
Ying Gao,Suimei Li,Xiaojia Zhang et al.
Ying Gao et al.
Off-white or yellowish shoots are common in tea plants (Camellia sinensis L.), and such albino variations are often accompanied by metabolic reprogramming, including increased contents of amino acids and lower levels of polyphenols. Nonethe...
Integrative Analysis of Differentially Expressed miRNAs and Noncoding RNA Networks Reveals Molecular Mechanisms Underlying Metritis in Postpartum Dairy Cows [0.03%]
差异表达miRNA及非编码RNA网络的整合分析揭示了产后奶牛子宫内膜炎的分子机制
Ramanathan Kasimanickam,Joao Ferreira,Vanmathy Kasimanickam
Ramanathan Kasimanickam
Postpartum metritis in dairy cows compromises reproductive performance and leads to substantial economic losses. This study investigated the molecular mechanisms underlying metritis by integrating high-throughput circulating microRNA (miRNA...
Irini Doytchinova,Stanislav Sotirov,Ivan Dimitrov
Irini Doytchinova
Tumor immunogenicity depends on the ability of peptides to form stable and specific interactions with both HLA molecules and T-cell receptors (TCRs). While HLA binding is essential, not all HLA-binding peptides elicit T-cell responses. This...
Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model [0.03%]
海瑞宁通过体外皮肤衰老模型减少细胞外基质降解、皮肤屏障功能障碍和炎症反应
Sullim Lee,Sanghyun Lee
Sullim Lee
With the growing interest in natural strategies for preventing skin aging, plant-derived compounds are being actively investigated for their potential protective effects against skin inflammation and extracellular matrix (ECM) degradation. ...
Serum Immunoglobulin Changes in Multiple Myeloma Patients Treated with CAR T-Cell Therapy [0.03%]
接受CAR-T细胞治疗的多发性骨髓瘤患者的血清免疫球蛋白变化
Alexa Burger,Ulrike Bacher,Michele Hoffmann et al.
Alexa Burger et al.
Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment for relapsed or refractory multiple myeloma (RRMM), with high response rates of 80-95%. Serum immunoglobulin changes have been observed throughout conventio...
Protective Effects of Inula japonica Leaf Extract Against PM10-Induced Oxidative Stress in Human Keratinocytes [0.03%]
日本铁线莲叶提取物对PM10诱导的人角质细胞氧化应激的保护作用
Yea Jung Choi,So-Ri Son,Sullim Lee et al.
Yea Jung Choi et al.
This study aimed to evaluate the protective effects of Inula japonica leaf extract against PM10-induced oxidative stress in normal human keratinocytes. Keratinocytes were pretreated with various concentrations of Inula japonica leaf extract...
Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and Treatment [0.03%]
同源重组缺陷在卵巢癌和乳腺癌中的作用：生物标志物、诊断与治疗
Bhaumik Shah,Muhammad Hussain,Anjali Seth
Bhaumik Shah
Homologous recombination deficiency (HRD) is a pivotal biomarker in precision oncology, driving therapeutic strategies for ovarian and breast cancers through impaired DNA double-strand break repair. This narrative review synthesizes recent ...
Physiological Mechanisms of and Therapeutic Approaches to the Gut Microbiome and Low-Grade Inflammation in Obesity [0.03%]
肥胖症的肠道菌群和轻度慢性炎症的生理机制及治疗途径
Agnieszka Pelc,Weronika Fic,Tymoteusz Typrowicz et al.
Agnieszka Pelc et al.
Obesity is a growing global health challenge, closely linked to chronic low-grade inflammation. This persistent, low-intensity immune response contributes to the development of metabolic, cardiovascular, and cancer-related diseases. A key p...