Molecular Characterization of Citrus Accessions Grown for Pre-Breeding Purposes [0.03%]
用于预育种目的的柑橘存株的分子特征鉴定
Israel Felipe Gonçalves Soares,Felipe Cruz Paula,Conceição de Maria Batista Oliveira et al.
Israel Felipe Gonçalves Soares et al.
The objective of this work was to analyse the genetic diversity of a population of Citrus spp. in the south of the State of Espírito Santo, Brazil, for pre-breeding studies. For that, a total of sixty genotypes were analysed, including ten...
Redox Homeostasis in Red Blood Cells: From Molecular Mechanisms to Antioxidant Strategies [0.03%]
红细胞氧化还原稳态：从分子机制到抗氧化策略
Sara Spinelli,Angela Marino,Alessia Remigante et al.
Sara Spinelli et al.
Red blood cells (RBCs) are uniquely vulnerable to oxidative stress due to their role in O2 transport and their high content of heme iron and polyunsaturated fatty acids (PUFAs). Despite lacking nuclei and organelles, RBC homeostasis relies ...
Hypersensitivity to Folic Acid and/or Folinic Acid-A Review of Clinical Cases, Potential Mechanism, Possible Cross-Allergies and Current Diagnostic Options [0.03%]
叶酸和/或钙 folinic acid过敏的临床病例、潜在机制、可能交叉过敏及当前诊断方法综述
Kinga Lis
Kinga Lis
Folic acid and its derivatives (e.g., folinic acid) are a group of water-soluble compounds collectively known as vitamin B9. Synthetic folic acid is a component of dietary supplements, medications and other pharmaceuticals and fortified foo...
Immune Organoids: A Review of Their Applications in Cancer and Autoimmune Disease Immunotherapy [0.03%]
免疫器官样组织：其在癌症和自身免疫性疾病免疫治疗中应用的综述
David B Olawade,Emmanuel O Oisakede,Eghosasere Egbon et al.
David B Olawade et al.
Immune organoids have emerged as a ground-breaking platform in immunology, offering a physiologically relevant and controllable environment to model human immune responses and evaluate immunotherapeutic strategies. Derived from stem cells o...
Integrating Primary and Metastatic scRNA-Seq and Bulk Data to Develop an Immune-Based Prognosis Signature for Colorectal Cancer [0.03%]
基于免疫的直肠癌预后标志物的开发：整合原发和转移scRNA-序和批量数据
Kaiyuan Xing,Liangshuang Li,Yingnan Ma et al.
Kaiyuan Xing et al.
Colorectal cancer (CRC) is a highly aggressive cancer, with its treatment and prognosis particularly challenging due to metastasis. The immune response is involved in the whole process of CRC development, and immunotherapy has increasingly ...
BCG Impact on PD-1/PD-L1 Expression in Peripheral Immunocytes of Cancer Patients-A Potential Explanation for Its Activity in Preventing Alzheimer's Disease [0.03%]
卡介苗对癌症患者外周免疫细胞PD-1/PD-L1表达的影响及其预防阿尔茨海默病的潜在作用机制
Benjamin Y Klein,Ofer N Gofrit,Charles L Greenblatt
Benjamin Y Klein
We found, retrospectively, that BCG therapy in non-muscle invasive bladder cancer (NMIBC) reduces the rate of Alzheimer's disease. Blockade of the ligand PD-L1 or its checkpoint receptor PD-1 has been shown to improve cognitive function and...
A Narrative Review of Heavy Metals and Sperm Quality: The Interplay with Antioxidant Imbalance and Reactive Oxygen Species [0.03%]
重金属与精子质量的叙述性回顾：抗氧化不平衡和活性氧的作用机制及其相互作用
Soukaina Azil,Khaoula Errafii,Moncef Benkhalifa et al.
Soukaina Azil et al.
Reproductive infertility is characterized by the inability to achieve pregnancy after a year or more of unprotected sexual intercourse. This review highlights the significant impact of exposure to both types of heavy metals (essential and n...
Evaluation of the Safety and Antiproliferative Activity of Bulgarian Rose Essential Oil: An In Vitro and In Silico Model of Colorectal Adenocarcinoma [0.03%]
保加利亚玫瑰精油安全性和抗增殖活性的评估：结直肠腺癌的体外和分子建模研究
Rayna Nenova,Kalin Kalinov,Deyana Nedeva et al.
Rayna Nenova et al.
The side effects of conventional cancer treatments, such as chemotherapy, radiotherapy, etc., worsen the quality of life of patients. Therefore, it is necessary to explore the possibilities of creating new drugs containing natural products ...
Biochemical Changes in Prostate Cancer: FMNL1 and PAK1 in Plasma and Urine [0.03%]
前列腺癌的生化变化：血浆和尿液中的FMNL1与PAK1
Elif Bilgin Doğru,Selçuk Erdem,Hilal Oğuz Soydinç et al.
Elif Bilgin Doğru et al.
Prostate cancer is a clinically heterogeneous disease. Since PSA is not cancer-specific, and due to the bone metastases seen in the advanced stage and bone deformations caused by hormone therapy, it is necessary to use new biomarkers. Formi...
Can Salivary Biomarkers Serve as Diagnostic and Prognostic Tools for Early Detection in Patients with Colorectal Cancer? A Systematic Review [0.03%]
唾液生物标志物能否作为诊断和预后工具来检测结直肠癌患者早期病变？系统性综述
Stanisław Krokosz,Maria Obrycka,Anna Zalewska
Stanisław Krokosz
Colorectal cancer (CRC) stands as one of the most prevalent and lethal forms of cancer worldwide with early detection playing a crucial role in improving the survival rate. Salivary biomarkers have emerged as a promising non-invasive altern...