K-562 Extracellular Vesicles Partially Protect Intact Cells from Oxidative Stress and Provide Limited Resistance to Imatinib [0.03%]
K-562细胞外泌体部分地保护完整细胞免受氧化应激并提供有限的伊马替尼耐药性作用
Jiana Sbiet,Einat Beery,Zinab Sarsor et al.
Jiana Sbiet et al.
Chronic myeloid leukemia (CML) results from the formation of the BCR-ABL1 chimeric protein which serves as a target for clinically used tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM). Although very efficient, the developm...
PRMT5 Inhibition as a Potential Strategy for KRAS Mutant CRC: Downstream Mediators of the PRMT5-KRAS Crosstalk [0.03%]
针对KRAS突变型结直肠癌的潜在治疗策略：PRMT5抑制与PRMT5-KRAS串扰的下游介体
Mark Spivak,Moshe Pahmer,Dorna Delrahimnia et al.
Mark Spivak et al.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide with KRAS mutations present in nearly 45% of cases. Compared to KRAS wild-type (WT) CRC, KRAS-mutant CRC is associated with poorer prognosis and fewer effectiv...
Circadian Rhythm Disruptions and Cardiovascular Disease Risk: The Special Role of Melatonin [0.03%]
昼夜节律紊乱与心血管疾病风险：褪黑素的特殊作用
Jarosław Nuszkiewicz,Wojciech Rzepka,Julia Markiel et al.
Jarosław Nuszkiewicz et al.
Circadian rhythms are endogenous biological cycles that regulate essential cardiovascular functions, including blood pressure, heart rate, vascular tone, and metabolic homeostasis. Disruption of these rhythms due to factors such as shift wo...
Astaxanthin Attenuates Chlorpyrifos-Induced Pulmonary Cytotoxicity by Modulating Mitochondrial Redox and Inflammatory Pathways [0.03%]
虾青素通过调节线粒体氧化还原和炎症通路来缓解氯吡格雷引起的肺细胞毒性
Mediha Demet Okudan Altındaş,Adem Güner
Mediha Demet Okudan Altındaş
Chlorpyrifos (CPF), an organophosphate pesticide, is known to induce pulmonary toxicity through oxidative stress, mitochondrial dysfunction, and inflammation. Astaxanthin (ASX), a xanthophyll carotenoid derived primarily from marine microal...
Juan Xue,Lei Li,Yongjia Shu et al.
Juan Xue et al.
Aralia chinensis L. has shown potential in breast cancer treatment, yet its pharmacodynamically active components and mechanisms remain undefined. To systematically identify the bioactive constituents absorbed into the bloodstream and eluci...
Potential of Alkaloids from Zanthoxylum nitidum var. tomentosum in Treating Rat Rheumatoid Arthritis Model and Validation of Molecular Mechanisms [0.03%]
密花山椒生物碱治疗胶原诱导型关节炎分子机制的潜在作用及验证研究
Yuanle Shen,Linghui Zou,Yinggang Zeng et al.
Yuanle Shen et al.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovial hyperplasia and joint destruction. Previous studies have demonstrated that the alkaloids of Rushanhu (ARSHs), the dried ro...
Partial Remission Without Recurrence in a 9-Year-Old Golden Retriever with Nasal Carcinoma Treated with Prednisolone/Chlorambucil Metronomic Combination Therapy: A Case Report and Literature Review of Molecular Mechanisms [0.03%]
美式利妥莫单抗与长春新碱联合治疗中国头颈部弥漫大B细胞淋巴瘤的病例报告及文献回顾：分子机制分析
Kyuhyung Choi
Kyuhyung Choi
This paper reports the first case in which a hyperlipidemic retriever (due to hypothyroidism) with a nasal tumor was successfully treated-achieving partial remission-and managed using a metronomic combination of chlorambucil (3.74 mg/m2, SI...
Targeting Intracellular Pathways in Atopic Dermatitis with Small Molecule Therapeutics [0.03%]
小分子药物治疗特应性皮炎的细胞内靶点和途径
Georgiana Nitulescu,Octavian Tudorel Olaru,Corina Andrei et al.
Georgiana Nitulescu et al.
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by immune dysregulation and epidermal barrier dysfunction. Advances in understanding the interplay of genetic predisposition, cytokine signaling, and en...
Exploring Novel Inhibitory Compounds Against Phosphatase Gamma 2: A Therapeutic Target for Male Contraceptives [0.03%]
探索新型磷脂酶γ 2抑制剂化合物：男用避孕药的潜在治疗靶点研究
Hashim M Aljohani,Bayan T Bokhari,Alaa M Saleh et al.
Hashim M Aljohani et al.
Men have limited options for contraception, despite the widely accepted public health benefits of it, placing the contraceptive burden solely on women. The current study focuses on inhibiting the PP1γ2 enzyme, which plays a role in sperm m...
The Duodenum-Centered Neurohormonal Hypothesis of Type 2 Diabetes: A Mechanistic Review and Therapeutic Perspective [0.03%]
基于十二指肠的2型糖尿病神经内分泌学说：机制性综述与治疗视角
Athena N Kapralou,Christos Yapijakis,George P Chrousos
Athena N Kapralou
Type 2 diabetes mellitus (T2DM) is a multifactorial disorder defined by insulin resistance, β-cell dysfunction, and chronic hyperglycemia. Although peripheral mechanisms have been extensively studied, increasing evidence implicates the gas...