The Role of Targeted Therapy and Immunotherapy in Metastatic GNET/Clear Cell Sarcoma (CCS) of the Gastrointestinal Tract: A Case Report [0.03%]
靶向治疗和免疫治疗在胃肠道转移性GNET/透明细胞肉瘤（CCS）中的作用：病例报告
Raluca Ioana Mihaila,Andreea Veronica Lazescu,Daniela Luminița Zob et al.
Raluca Ioana Mihaila et al.
Background: Gastrointestinal neuroectodermal tumour (GNET), also known as clear cell sarcoma (CCS) of the gastrointestinal tract, is a rare neural crest-derived malignancy characterized by EWSR1-ATF1 or EWSR1-CREB1 fusions. Due to its rarit...
KMO Inhibition Improves Seizures and Depressive-like Behaviors Without Aggravating Cognitive Impairment in Epileptic Mice [0.03%]
KMO抑制改善癫痫小鼠的癫痫发作和抑郁样行为而不加重认知障碍
Jingwen Xu,Yifen Huang,Liping Wei et al.
Jingwen Xu et al.
The objective of this study is to investigate the effects of kynurenine-3-monooxygenase (KMO) inhibition on seizures, depressive-like behaviors, and cognitive functions in epileptic mice, and to elucidate its impact on the kynurenine metabo...
B-Cell Acute Lymphoblastic Leukemia in a Child with Down Syndrome and High-Risk Genomic Lesions [0.03%]
伴有高危基因改变的儿童唐氏综合征患者B细胞急性淋巴细胞白血病病例报告
Cristina-Crenguţa Albu,Florin Bica,Laura Nan et al.
Cristina-Crenguţa Albu et al.
Background: Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with cure rates exceeding 80% due to advancements in treatment protocols and supportive care. However, in children with Down syndrome (DS), ALL (DS-ALL)...
Immune-Epigenetic Effects of Environmental Pollutants: Mechanisms, Biomarkers, and Transgenerational Impact [0.03%]
环境污染物的免疫-表观遗传效应：机制、生物标志物和跨世代影响
Sandeep R Reddy,Manjunatha Bangeppagari,Sang Joon Lee
Sandeep R Reddy
Environmental pollutants such as heavy metals, endocrine-disrupting chemicals, microplastics, and airborne particulates are increasingly recognized for their potential to influence immune function through epigenetic mechanisms. This review ...
Homologous Recombination Proficiency in High-Grade Serous Epithelial Ovarian Cancer Tumors: The Dark Side of the Moon [0.03%]
高级别浆液性卵巢癌肿瘤的同源重组修复能力：月亮的暗面
Marina Pavanello,Carolina Martins Vieira,Martina Parenza Arenhardt et al.
Marina Pavanello et al.
Extensive research on homologous-recombination-deficient (HRD) tumors has led to advancements in targeted therapies, such as PARP inhibitors (PARPis). Around 50% of high-grade serous ovarian cancer (HGSOC) cases exhibit HR deficiency, but u...
Effect of Dietary Exposure to Low-Density Polyethylene Microplastics and Their Potential Role as Estrogen Vectors In Vivo [0.03%]
低密度聚乙烯微塑料的膳食暴露及其体内潜在的雌激素载体作用的影响
Noura Al-Jandal,Azad Ismail Saheb,Abdulaziz Alkhubaizi et al.
Noura Al-Jandal et al.
Microplastics (MPs) are a growing environmental concern due to their ability to adsorb hazardous chemicals, such as estrogens, and be ingested by marine organisms. This study focuses on low-density polyethylene (LDPE), a polymer widely used...
Genome Wide Identification of Sesame Dof Transcription Factors and Functional Analysis of SiDof8, SiDof10 and SiDof34 in Fatty Acid Synthesis [0.03%]
基于全基因组鉴定芝麻Dof家族转录因子及SiDof8、SiDof10和SiDof34参与脂肪酸合成的功能分析
Feicui Zhang,Shanyu Chen,Feiling Song et al.
Feicui Zhang et al.
The Dof (DNA binding with one finger) protein is one of the unique transcription factors in plants, and it plays an important role in plant growth and stress response. Sesame is an oil-bearing crop with high oil content and rich nutrition. ...
Histone-, Receptor-, and Integrin-Related Gene Products and ADAM28 as Relevant to B-Cell Acute Lymphoblastic Leukemia (B-ALL) [0.03%]
与B淋巴细胞急性淋巴细胞性白血病(B-ALL)相关的组蛋白、受体和整合素相关基因产物以及ADAM28
Makayla R K Wilkins,Brett E Pickett
Makayla R K Wilkins
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with pediatric ALL having a ~90 percent cure rate, while the adult cure rate is considerably lower. B-cell acute lymphoblastic leukemia (B-ALL) is the most common subty...
Long Non-Coding RNAs: Significant Drivers of Carcinogenesis Mechanisms in Head and Neck Squamous Cell Carcinoma [0.03%]
长链非编码RNA：头颈鳞状细胞癌致癌机制的重要驱动因素
Camelia Mia Hotnog,Marinela Bostan,Matei Anghelescu et al.
Camelia Mia Hotnog et al.
Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with a complex molecular landscape. Despite extensive research, our understanding of the molecular mechanisms remains incomplete, hindering the development of effective t...
Sublingual Dripping Pill Formulation of Ganoderma amboinense Fruiting Body Extract Attenuates CCl4-Induced Liver Fibrosis via Multi-Pathway Regulation [0.03%]
灵芝子实体滴丸对四氯化碳致肝纤维化的多通路调节作用研究
Chin-Feng Liu,Chong-Ming Pan,Chun-Lin Lee
Chin-Feng Liu
Liver fibrosis remains difficult to treat, in part because many hepatoprotective triterpenoids suffer from poor oral bioavailability and lack of optimized delivery formats. Ganoderma amboinense is a rare "antler" reishi species long valued ...