Alexander Panov,Vladimir Mayorov,Sergey Dikalov et al.
Alexander Panov et al.
For a long time, glycolysis and mitochondrial oxidative phosphorylation were opposed to each other. Glycolysis works when there is a lack of oxygen; the mitochondria supply ATP in an oxygen environment. In recent decades, it has been discov...
Genomic Instability and Adaptive Evolution Induced by RFA Insufficiency in Saccharomyces cerevisiae [0.03%]
RFA不足引起的基因组不稳定性及适应性进化
Runbiao Zhang,Liyan Tian,Min He et al.
Runbiao Zhang et al.
This study systematically investigated the genomic alterations in Saccharomyces cerevisiae driven by Replication Factor A (RFA) dosage insufficiency using a promoter-replacement strategy combined with mutation accumulation and whole-genome ...
Mónica L Acevedo,Francisco Aguayo,Julio C Osorio et al.
Mónica L Acevedo et al.
Mouse Mammary Tumor Virus (MMTV) is an established mammary carcinogen in mice, yet the relevance of MMTV-like agents to human breast cancer remains debated. Across cohorts worldwide, PCR-based detection of MMTV-like DNA, in situ RNA localiz...
Integrative Multi-Omics and Machine Learning Identify ID1 as a Candidate Gene Associated with Abdominal Aortic Aneurysm [0.03%]
整合多组学和机器学习鉴定ID1为腹主动脉瘤相关候选基因
Feng Guo,Michael Keese,Yu Zhao et al.
Feng Guo et al.
Abdominal aortic aneurysm (AAA) is a fatal vascular disorder driven by immune dysregulation and extracellular matrix (ECM) degradation, yet its molecular mechanisms remain unclear. This study investigated the mechanistic role of ID1 in AAA ...
Editorial for the Special Issue "Targeting Tumor Microenvironment for Cancer Therapy, 3rd Edition" [0.03%]
特刊“靶向肿瘤微环境的癌症治疗（第3版）”主编前言
Cheng-Che Lee,Ming-Wei Lin
Cheng-Che Lee
The tumor microenvironment (TME) is a highly dynamic and heterogeneous ecosystem composed of cancer cells, stromal components, immune cells, and extracellular matrix [...].
Genes and Gene Functions Associated with Morphological, Productive, Reproductive, and Carcass Quality Traits in Pigs: A Functional Bioinformatics Approach [0.03%]
与猪形态、生产和繁殖以及胴体品质性状相关的基因及基因功能的生物信息学分析
Wilber Hernández-Montiel,Víctor M Meza-Villalvazo,Dany A Dzib-Cauich et al.
Wilber Hernández-Montiel et al.
Understanding the functional mechanisms of genes influencing economically important traits in the domestic pig is essential for optimizing marker-assisted selection (MAS). This study aimed to characterize the biological functions, molecular...
Identification of Leaf Waxy Candidate Gene and Expression Changes in Related Genes in Response to Cold Stress of Cabbage (Brassica oleracea L.) [0.03%]
白菜叶片蜡质相关候选基因的鉴定及响应冷害胁迫表达量变化分析
Dengkui Shao,Yanjing Ren,Changrong Deng et al.
Dengkui Shao et al.
In cabbage, epidermal wax plays a key role in adaptation to abiotic and biotic stresses. The glossy green cabbage variety, which has less wax, is becoming increasingly popular on the market. In this study, the highly inbred waxy cabbage HQ2...
A Water Extract of Mixed Mushroom Mycelia Mitigates Cognitive Deficit and Oxidative Stress After Global Cerebral Ischemia-Reperfusion Injury [0.03%]
混合蘑菇菌丝水提物通过减少全脑缺血再灌注损伤后的认知障碍和氧化应激起缓解作用
Hyeon-Jeong Noh,Ji-Hyun Moon,Hye Jeong Ahn et al.
Hyeon-Jeong Noh et al.
Background: GMK is a bioactive material newly identified from a water extract of mixed mushroom mycelia (Phellinus linteus, Inonotus obliquus, and Ganoderma lucidum). It has shown protective effects against glutamate-indu...
Antifungal Activity of Four Medium-Chain Fatty Acids and γ-Undecalactone Against Candida albicans [0.03%]
四种中链脂肪酸和γ-月桂内酯对白色念珠菌的抗真菌活性研究
Miyako Yoshida,Hiroaki Terada,Saki Hayashi et al.
Miyako Yoshida et al.
In this paper, the antifungal activity of medium-chain fatty acids with 8 to 11 carbon atoms in their chemical structures, medium-chain fatty acid lactones, and a partially fluorinated medium-chain fatty acid was determined. As the length o...
Functional DNA Repair Profiling in Translational Medicine: Benchmarking Comet, γH2AX, and NGS Assays Against Clinical Constraints [0.03%]
转化医学中的功能型DNA修复检测：基于临床需求的彗星试验、γH2AX免疫细胞化学和NGS测序技术比较基准研究
Anna Macieja,Marta Poplawska,Karolina Przybylowska-Sygut et al.
Anna Macieja et al.
Quantifying DNA repair capacity (DRC) is pivotal for stratifying patients in oncology and autoimmune disorders, yet methodological heterogeneity compromises data reproducibility. While basic research relies on genetically encoded reporters,...