Integrated Transcriptomic and Metabolomic Analysis Reveals Molecular Signatures Associated with Natural Degeneration of Puccinia striiformis f. sp. tritici [0.03%]
整合转录组和代谢组分析揭示了Puccinia striiformis专化型tritici自然退化相关的分子标志物
Congying Yuan,Tianyu Long,Jiani Dong et al.
Congying Yuan et al.
Stripe rust of wheat, caused by the obligate biotrophic fungus Puccinia striiformis f. sp. tritici (Pst), is a devastating disease. The natural degeneration and viability loss of Pst urediniospores directly impact its dispersal and epidemic...
T174M-M235T AGT Gene Haplotypes in Women with Pre-Eclampsia from Northwest Mexico: A Pilot Case-Control Study [0.03%]
墨西哥西北部先兆子痫妇女中的AGT基因型位点T174M和M235T的单倍体型：一项病例对照研究
Jorge H Portillo-Gallo,Jorge Manuel Sánchez-González,Ana Miriam Saldaña-Cruz et al.
Jorge H Portillo-Gallo et al.
Pre-eclampsia is a Hypertensive Disorder of Pregnancy (HDP) characterized by hypertension and proteinuria, affecting 2-8% of pregnancies worldwide and constituting a major public health concern. Genes of the renin-angiotensin system have be...
Association of Serum Creatinine, Urea, and Glomerular Filtration Rate with the Progression of Diabetic Associated Kidney Complications: A Retrospective Case-Control Study [0.03%]
糖尿病肾病进展的横断面病例-队列研究：血肌酐、尿素和肾小球滤过率的相关性分析
Shahad Saif Khandker,Shoumik Kundu,Farhana Ahmed et al.
Shahad Saif Khandker et al.
Introduction: Diabetes mellitus (DM) is a prevalent metabolic disorder frequently leading to serious renal complications, particularly diabetic nephropathy. This retrospective case-control study investigated the levels an...
From Genetic Determinism to Epigenetic Regulation: Paradigm Shifts in the Understanding of Neurodevelopmental Disorders [0.03%]
从基因决定论到表观遗传调控——神经发育障碍研究范式的转变
Ernesto Burgio,Annamaria Porru,Chiara Pettini et al.
Ernesto Burgio et al.
Over the past two decades, advances in the understanding of epigenetic mechanisms-driven by the rapid expansion of omics technologies-have catalyzed a major paradigm shift in biology: from the genetic determinism and linear causality of the...
Subfunctionalization of CpSVP-Y Paralog Contributes to Male Reproductive Fitness in Papaya [0.03%]
番木瓜CpSVP-Y旁系同源基因的亚功能化对其雄性生殖适合度的贡献
Julie Nguyen-Edquilang,Jingjing Yue,Ray Ming
Julie Nguyen-Edquilang
Papayas possess three sex genotypes: female XX, male XY, and hermaphrodite XYh. Only male plants produce long peduncles with numerous flowers, a trait that improves reproductive success. The gene SHORT VEGETATIVE PHASE (CpSVP) is located on...
Reconstructing Liver Fibrosis: 3D Human Models, Microbiome Interfaces, and Therapeutic Innovation [0.03%]
肝脏纤维化重构：三维人类模型、微生物组界面和治疗创新
Dileep G Nair,Divya B Nair,Ralf Weiskirchen
Dileep G Nair
Liver fibrosis is a significant consequence of severe liver injury resulting from viral hepatitis, alcohol, and metabolic dysfunction. Progressive fibrosis and ultimate cirrhosis are leading causes of morbidity and mortality worldwide, gene...
Association Between Catenin Beta-1 (CTNNB1) Gene Polymorphisms and Non-Traumatic Osteonecrosis of the Femoral Head (ONFH) [0.03%]
β-连环蛋白基因多态性与中国人群非创伤性股骨头坏死关系的研究
I-Chang Lai,De-Yi Liu,Shih-Chan Hsu et al.
I-Chang Lai et al.
Non-traumatic osteonecrosis of the femoral head (ONFH) is a multifactorial disorder in which genetic susceptibility is thought to play an important role, yet the contribution of many candidate genes remains unclear. The catenin beta-1 (CTNN...
Endothelial Cell Activation by SARS-CoV-2 Spike Protein and Its RBD: Central Player of the Immunothrobotic Response in COVID-19 [0.03%]
SARS-CoV-2刺突蛋白及其RBD激活内皮细胞作用：在COVID-19免疫抑制反应中的核心作用
Alan Cano-Mendez,Nallely Garcia-Larragoiti,Yesenia Ambriz-Murillo et al.
Alan Cano-Mendez et al.
COVID-19 has been associated with an active immunothrombotic process. The involvement of endothelial cells (ECs) in the feedback loop of the inflammatory and thrombotic process characteristic of COVID-19, as well as its differences with oth...
Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy [0.03%]
探索常染色体显性遗传的非综合征单基因肥胖症：从基因到治疗
Giovanni Luppino,Mara Giordano,Francesca Franchina et al.
Giovanni Luppino et al.
Genetic factors are key determinants in the pathophysiology of obesity, regulating energy homeostasis. Monogenic non-syndromic obesity accounts for 2-3% of obesity in both children and adults and is most often attributable to mutations in g...
From Gas Chromatography-Mass Spectrometry (GC-MS) to Network Pharmacology: System-Level Insights into the Multi-Target Biological Potential of Flaveria trinervia (Spreng.) C. Mohr [0.03%]
从气相色谱-质谱（GC-MS）到网络药理学：(Flaveria trinervia(Spreng.)C.Mohr)多靶生物潜能的系统见解
Christopher Torres Flores,Eduardo Pérez-Campos,Laura Pérez-Campos Mayoral et al.
Christopher Torres Flores et al.
Flaveria trinervia (Spreng) C. Mohr is a plant traditionally used in Mexican medicine. In this study, gas chromatography-mass spectrometry (GC-MS) combined with network pharmacology was employed to characterize volatile and semi-volatile me...