Ganoderic Acid A Attenuates Pathological Cardiac Hypertrophy by Attenuating Inflammatory Responses [0.03%]
灵芝酸A通过减轻炎症反应缓解病理性心脏肥厚
Changlin Zhen,Yonghui Zhang,Hui Tan et al.
Changlin Zhen et al.
Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. Ganoderic acid A (GAA), the primary bioactive constituent of Ganoderma lucidum (G. lucidum), is known for its stable chemical properties and diverse bi...
Chemical Composition and Biological Activities of Bulgarian Thyme (Thymus callieri Borbás ex Velen) and Summer Savory (Satureja hortensis L.) Essential Oils [0.03%]
保加利亚百里香（Thymus callieri）和夏藿香（Satureja hortensis）精油的化学成分及生物活性研究
Yulian Tumbarski,Ivan Ivanov,Ivayla Dincheva et al.
Yulian Tumbarski et al.
Thyme (Thymus callieri Borbás ex Velen) and summer savory (Satureja hortensis L.) are aromatic plants from the Lamiaceae family widely used in traditional medicine and the food industry. This study provides a comparative analysis of the ph...
Protein NS4A of ZIKV Inhibits Glycolytic Flux by Targeting Enolase-1 [0.03%]
ZIKV蛋白NS4A通过靶向烯醇化酶-1抑制糖酵分解流动
Rui Ma,Kexin Zhang,Zhengfei Qi et al.
Rui Ma et al.
NS4A plays a role in forming the flavivirus replication complex, which inhibits apoptosis in host cells by inducing autophagy, thereby promoting viral replication. The host protein ENO1 interacts with NS4A, but the precise mechanism underly...
Differential TET1/2/3 Protein Expression in Circulating Leukocytes of Statin-Treated Patients with HFrEF [0.03%]
他汀治疗的心力衰竭患者循环白细胞中TET1/2/3蛋白的差异表达
Anna Wołowiec,Łukasz Wołowiec,Albert Jaśniak et al.
Anna Wołowiec et al.
Epigenetic mechanisms, including DNA methylation and hydroxymethylation, contribute to inflammation, cardiac remodelling and progression of heart failure. Ten-Eleven Translocation (TET) dioxygenases are key regulators of these processes, bu...
Advances in the Treatment of Autosomal Dominant Polycystic Kidney Disease and Novel Therapeutic Targets [0.03%]
常染色体显性遗传多囊肾病治疗进展与新型治疗靶点探讨
Wenzheng Zhang,Tianze Sun,Xin Wang et al.
Wenzheng Zhang et al.
Autosomal dominant polycystic kidney disease (ADPKD), with a prevalence of approximately 1 in 1000, is the most common inherited cause of end-stage renal disease (ESRD). It is primarily caused by mutations in the PKD1 or PKD2 genes. Multipl...
Can DNA Methylation in Peritumoral and Contralateral Breast Tissue Predict Recurrence or Second Breast Cancers? [0.03%]
肿瘤周围和对侧乳腺组织的DNA甲基化能预测复发或第二原发乳腺癌吗？
Jennifer Hammer,Marie Malvaux,Louise van Drooghenbroeck et al.
Jennifer Hammer et al.
Despite major advances in early breast cancer detection and therapeutic strategies, locoregional and distant recurrences, as well as the development of a second primary breast cancer, remain major clinical challenges. Current prognostic too...
Integrated Transcriptome and Metabolome Analysis Reveals Differential Berberine Biosynthesis in Leaves and Stems of Phellodendron amurense Rupr. Plantlets [0.03%]
整合转录组和代谢组分析揭示了Berberine在Phellodendron amurense Rupr.植物体的叶片和茎秆中的生物合成差异
Wei Li,Xuefang Wang,Cancan Lv et al.
Wei Li et al.
Phellodendron amurense Rupr. is a native tree species in China, well known for its significant medicinal value. Its pharmacological activity mainly derives from the abundant isoquinoline alkaloids in its bark. Berberine serves as the key co...
Natural Plant-Derived Compounds Targeting Oxidative Stress and Inflammation in NAFLD-Mechanisms and Repositioning Potential [0.03%]
针对NAFLD氧化应激和炎症的天然植物衍生化合物-机制与老药新用潜力
Rafailia-Eirini Theodorou,Nikiforos Vrettos,Panagiotis Theodosis-Nobelos
Rafailia-Eirini Theodorou
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, with advanced stages potentially progressing to hepatocellular carcinoma. It is a multifactorial condition associated with metabolic syndrome, diabetes, and hormona...
Characterization of Genes Related to Intramuscular Fat Deposition in Muscles of Piglets Under Cold Exposure by Whole Transcriptome Sequencing [0.03%]
仔猪冷应激下肌内脂肪沉积相关基因的转录组分析
Fang Wang,Liang Wang,Zhenhua Guo et al.
Fang Wang et al.
Background/objectives: Understanding the regulatory mechanisms of intramuscular fat accumulation is crucial for maintaining skeletal muscle function and treating muscle-related diseases. It is known that cold exposure can...
Transcriptomics, Proteomics and Network Pharmacology Reveal the Mechanisms of Cantharidin-Induced Kidney Injury in Rats [0.03%]
通过转录组学、蛋白质组学和网络药理学探讨斑蝥素致大鼠肾脏损伤的机制研究
Xiaotong Duan,Cancan Zhao,Sali Li et al.
Xiaotong Duan et al.
Cantharidin (CTD), the principal active constituent of the traditional Chinese medicine (TCM) Mylabris, exhibits potent antitumor activity. However, its clinical application is limited by organ toxicity (especially nephrotoxicity), and the ...